🔎 Trials Near Me

Home › Germ Cell and Embryonal Cancer › NCT03067181

Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

RecruitingPhase 3

A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors

Who can join

All ages · All sexes

Full eligibility criteria
Inclusion Criteria:

* There is no age limit for the low risk stratum (stage I ovarian immature teratoma and stage I non-seminoma or seminoma malignant GCT \[all sites\])
* Standard risk 1: Patients must be \< 11 years of age at enrollment
* Standard risk 2: Patients must be \>= 11 and \< 25 years of age at enrollment
* Patients enrolling on one of the low risk arms must be newly diagnosed with a stage I germ cell tumor; for the standard risk arms, patients must be newly diagnosed with malignant germ cell tumor (stage II or higher).

  * Histologic confirmation of a primary extracranial germ cell tumor in any of the categories outlined below is required of all patients at enrollment , with the following exceptions:

    * Among patients were initially diagnosed with completely resected non-seminoma malignant GCT and later recur during observation post surgery, a diagnostic biopsy is not required for enrollment if elevated tumor markers rise to \> 5 x upper limit of normal (ULN) on at least 2 measurements taken at least 1 week apart. The pathology report of initial surgery should be provided
    * Patients may be enrolled without histologic or cytologic confirmation in the rare case where there are exceptionally raised tumor markers (alpha fetoprotein \[AFP- ≥ 500 ng/mL or HCG ≥ 500 IU/L) and radiologic features consistent with GCT. In addition, the treating clinician must deem that the patient's tumor is not suitable for upfront resection and that a biopsy is not in the patient's best interest; or that there is a need to start therapy urgently
* Low risk immature teratoma (IT); site: ovarian; stage: any; grade: any; histology: pure immature teratoma, mixed immature and mature teratoma, (may contain microscopic foci of yolk sac tumor \[\< 3 mm\], but no other pathological evidence of MGCT); tumor markers: alpha-FP =\< 1,000 ng/mL, beta-HCG institutional normal; all ages
* Low risk stage I non-seminoma MGCT; site: ovarian, testicular, or extragonadal; stage: COG stage I, FIGO stage IA and IB, American Joint Committee on Cancer (AJCC) testicular stage IA, IB and IS; histology: must contain at least one of the following: yolk sac tumor, embryonal carcinoma, or choriocarcinoma (pure or mixed); all ages
* Low risk stage I seminoma-MGCT; site: testicular; stage: COG stage I; AJCC testicular stage IA IB, and IS; histology: must contain only seminoma; may contain immature/mature teratoma; may NOT contain yolk sac tumor, embryonal carcinoma, or choriocarcinoma; all ages
* Standard risk 1 (SR1); site: ovarian, testicular, or extragonadal; stage: COG stage II-IV, FIGO stage IC-IV, (International Germ Cell Consensus Classification \[IGCCC\] criteria DO NOT apply); histology: must contain at least one of the following: yolk sac tumor, embryonal carcinoma, or choriocarcinoma; age (years) \< 11
* Standard risk 2 (SR2)

  * Site: ovarian; stage: COG stage II, III, and III-X, FIGO stage IC, II and III; histology: must contain at least one of the following: yolk sac tumor, embryonal carcinoma, or choriocarcinoma; age (years) \>= 11 and \< 25
  * Site: testicular; stage: COG stage II-IV, AJCC stage II, III, IGCCC good risk; histology: must contain at least one of the following: yolk sac tumor, embryonal carcinoma, or choriocarcinoma: must be IGCCC good risk; post op: alpha-FP \< 1,000 ng/mL, beta-HCG \< 5,000 IU/mL and lactate dehydrogenase (LDH) \< 3.0 x normal; age (years) \>= 11 and \< 25
* Notes:

  * IGCCC criteria only apply to SR2 patients with a testicular primary tumor
  * Use post-op tumor marker levels to determine IGCCC risk group
  * Pure seminoma patients are not eligible for the standard risk arms of the study
  * For the low risk stage I non-seminoma MGCT and the standard risk arms, components of yolk sac tumor, embryonal carcinoma, or choriocarcinoma can be mixed with other forms of GCT, such as seminoma or mature or immature teratoma; if yolk sac tumor is the only malignant component present, then it must be deemed by the pathologist to be greater than a "microscopic component" of yolk sac tumor
* Patients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1, 2 or 3; use Karnofsky for patients \> 16 years of age and Lansky for patients =\< 16 years of age
* Organ function requirements apply ONLY to patients who will receive chemotherapy (SR1 and SR2 patients)
* Adequate renal function defined as:
* Creatinine clearance or radioisotope glomerular filtration rate (GFR) \>= 70 mL/min/1.73 m\^2 (within 7 days prior to enrollment) OR
* A serum creatinine based on age/sex as follows (within 7 days prior to enrollment): (mg/dL)

  * 1 month to \< 6 months male: 0.4 female: 0.4
  * 6 months to \< 1 year male: 0.5 female: 0.5
  * 1 to \< 2 years male: 0.6 female: 0.6
  * 2 to \< 6 years male: 0.8 female: 0.8
  * 6 to \< 10 years male: 1 female: 1
  * 10 to \< 13 years male: 1.2 female: 1.2
  * 13 to \< 16 years: male: 1.5 female: 1.4
  * \>= 16 years male: 1.7 female: 1.4
* Total bilirubin =\< 2 x upper limit of normal (ULN) for age (within 7 days prior to enrollment)

  * Unless due to Gilbert's disease, malignant involvement of liver or vanishing bile duct syndrome
* Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \< 3 x upper limit of normal (ULN) (within 7 days prior to enrollment)

  * Unless due to Gilbert's disease, malignant involvement of liver or vanishing bile duct syndrome
* Peripheral absolute neutrophil count (ANC) \>= 750/mm\^3 (within 7 days prior to enrollment) AND
* Platelet count \>= 75,000/mm\^3 (within 7 days prior to enrollment)
* Patients enrolling on the standard risk arms must be medically fit to receive protocol treatment and with no contraindications to protocol treatment
* Eligibility criteria to participate in the pilot study of the AYA-Hears instrument (patient reported outcomes \[PROs\] of ototoxicity) Note: participants in group 1 will not receive AGCT1531 protocol-directed therapy; all other AYA-HEARS patients must be enrolled on the AGCT1531 SR2 arm in order to participate
* \>= 11 and \< 25 years old at enrollment
* Able to fluently speak and read English
* Has received prior cisplatin- or carboplatin-based chemotherapy regimen for malignancy including diagnoses other than germ cell tumor
* Followed for cancer or survivorship care at one of the following institutions:

  * Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
  * Dana Farber/Harvard Cancer Center
  * Hospital for Sick Children
  * Children's Hospital of Eastern Ontario
  * Oregon Health and Science University
  * Seattle Children's Hospital
  * Yale University

Exclusion Criteria:

* Patients with any diagnoses not listed including:

  * Stage I testicular cancer patients who have undergone primary RPLND (retroperitoneal lymph node dissection)
  * Pure ovarian or extragonadal dysgerminoma/seminoma
  * Pure mature teratoma
  * Pure immature teratoma with alpha-fetoprotein (AFP) \>= 1000 ng/mL
  * "Poor risk" GCT (age \>= 11 years old and COG stage IV ovarian, COG stage II- IV extragonadal, or IGCCC intermediate or poor risk testicular), or
  * Primary central nervous system (CNS) germ cell tumor
  * Germ cell tumor with somatic malignant transformation
  * Spermatocytic seminoma
* Patients must have had no prior systemic therapy for the current cancer diagnosis
* Patients must have had no prior radiation therapy with the exception of CNS irradiation of brain metastases; (this exception only applies to SR1 patients; any patients over age 11 with distant metastases to brain \[stage IV disease\] would be considered poor risk and therefore not eligible for this trial)
* Patients with significant, pre-existing co-morbid respiratory disease that contraindicate the use of bleomycin are ineligible for the standard risk arms of the trial
* Female patients who are pregnant since fetal toxicities and teratogenic effects have been noted for several of the study drugs; a pregnancy test is required for female patients of childbearing potential; (this criteria applies ONLY to patients who will receive chemotherapy \[SR1 and SR2 patients\])
* Lactating females who plan to breastfeed their infants; (this criteria applies ONLY to patients who will receive chemotherapy \[SR1 and SR2 patients\])
* Sexually active patients of reproductive potential who have not agreed to use an effective contraceptive method for the duration of their study participation; (this criteria applies ONLY to patients who will receive chemotherapy \[SR1 and SR2 patients\])

About the study

This phase III trial studies how well active surveillance help doctors to monitor subjects with low risk germ cell tumors for recurrence after their tumor is removed. When the germ cell tumor has spread outside of the organ in which it developed, it is considered metastatic. Chemotherapy drugs, such as bleomycin, carboplatin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The trial studies whether carboplatin or cisplatin is the preferred chemotherapy to use in treating metastatic standard risk germ cell tumors.

What is being tested

Sponsor: Children's Oncology Group · Participants: 1,780 · Started: May 25, 2017

Contact the study team

Official record on ClinicalTrials.gov — NCT03067181

Locations in the U.S.

AlabamaChildren's Hospital of Alabama, Birmingham
AlaskaAlaska Breast Care and Surgery LLC, Anchorage
Alaska Oncology and Hematology LLC, Anchorage
Alaska Women's Cancer Care, Anchorage
Anchorage Associates in Radiation Medicine, Anchorage
Katmai Oncology Group, Anchorage
Providence Alaska Medical Center, Anchorage
ArizonaKingman Regional Medical Center, Kingman
Banner Children's at Desert, Mesa
Phoenix Childrens Hospital, Phoenix
ArkansasArkansas Children's Hospital, Little Rock
CARTI Cancer Center, Little Rock
CaliforniaKaiser Permanente-Anaheim, Anaheim
PCR Oncology, Arroyo Grande
Kaiser Permanente-Bellflower, Bellflower
Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank
Kaiser Permanente Downey Medical Center, Downey
Kaiser Permanente-Fontana, Fontana
UC San Diego Moores Cancer Center, La Jolla
Loma Linda University Medical Center, Loma Linda
Miller Children's and Women's Hospital Long Beach, Long Beach
Cedars-Sinai Medical Center, Los Angeles
Children's Hospital Los Angeles, Los Angeles
Kaiser Permanente Los Angeles Medical Center, Los Angeles
Mattel Children's Hospital UCLA, Los Angeles
Valley Children's Hospital, Madera
Providence Queen of The Valley, Napa
Kaiser Permanente-Oakland, Oakland
UCSF Benioff Children's Hospital Oakland, Oakland
Children's Hospital of Orange County, Orange
Lucile Packard Children's Hospital Stanford University, Palo Alto
University of California Davis Comprehensive Cancer Center, Sacramento
Kaiser Permanente-San Diego Mission, San Diego
Naval Medical Center -San Diego, San Diego
Rady Children's Hospital - San Diego, San Diego
UCSF Medical Center-Mission Bay, San Francisco
Providence Medical Foundation - Santa Rosa, Santa Rosa
Providence Santa Rosa Memorial Hospital, Santa Rosa
ColoradoChildren's Hospital Colorado, Aurora
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver
ConnecticutConnecticut Children's Medical Center, Hartford
Yale University, New Haven
DelawareAlfred I duPont Hospital for Children, Wilmington
District of ColumbiaChildren's National Medical Center, Washington D.C.
FloridaBroward Health Medical Center, Fort Lauderdale
Golisano Children's Hospital of Southwest Florida, Fort Myers
UF Health Cancer Institute - Gainesville, Gainesville
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
Nemours Children's Clinic-Jacksonville, Jacksonville
Miami Cancer Institute, Miami
Nicklaus Children's Hospital, Miami
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
AdventHealth Orlando, Orlando
Arnold Palmer Hospital for Children, Orlando
Nemours Children's Hospital, Orlando
Nemours Children's Clinic - Pensacola, Pensacola
Johns Hopkins All Children's Hospital, St. Petersburg
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
Tampa General Hospital, Tampa
Saint Mary's Medical Center, West Palm Beach
GeorgiaChildren's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta
Augusta University Medical Center, Augusta
Atrium Health Navicent, Macon
Memorial Health University Medical Center, Savannah
HawaiiKapiolani Medical Center for Women and Children, Honolulu
Straub Clinic and Hospital, Honolulu
IdahoSaint Luke's Cancer Institute - Boise, Boise
Saint Luke's Cancer Institute - Fruitland, Fruitland
Saint Luke's Cancer Institute - Meridian, Meridian
Saint Luke's Cancer Institute - Nampa, Nampa
Saint Luke's Cancer Institute - Twin Falls, Twin Falls
IllinoisIllinois CancerCare-Bloomington, Bloomington
Illinois CancerCare-Canton, Canton
Memorial Hospital of Carbondale, Carbondale
SIH Cancer Institute, Carterville
Illinois CancerCare-Carthage, Carthage
Centralia Oncology Clinic, Centralia
Lurie Children's Hospital-Chicago, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
University of Illinois, Chicago
Cancer Care Specialists of Illinois - Decatur, Decatur
Decatur Memorial Hospital, Decatur
Illinois CancerCare-Dixon, Dixon
Crossroads Cancer Center, Effingham
Illinois CancerCare-Eureka, Eureka
NorthShore University HealthSystem-Evanston Hospital, Evanston
Illinois CancerCare-Galesburg, Galesburg
NorthShore University HealthSystem-Glenbrook Hospital, Glenview
NorthShore University HealthSystem-Highland Park Hospital, Highland Park
Illinois CancerCare-Kewanee Clinic, Kewanee
Illinois CancerCare-Macomb, Macomb
Loyola University Medical Center, Maywood
HSHS Saint Elizabeth's Hospital, O'Fallon
Advocate Children's Hospital-Oak Lawn, Oak Lawn
Illinois CancerCare-Ottawa Clinic, Ottawa
Advocate Children's Hospital-Park Ridge, Park Ridge
Illinois CancerCare-Pekin, Pekin
OSF Saint Francis Radiation Oncology at Pekin, Pekin
Illinois CancerCare-Peoria, Peoria
Methodist Medical Center of Illinois, Peoria
OSF Children's Hospital of Illinois, Peoria
OSF Saint Francis Medical Center, Peoria
OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria
Illinois CancerCare-Peru, Peru
Valley Radiation Oncology, Peru
Illinois CancerCare-Princeton, Princeton
Saint John's Hospital, Springfield
Southern Illinois University School of Medicine, Springfield
Springfield Clinic, Springfield
Springfield Memorial Hospital, Springfield
Illinois CancerCare - Washington, Washington
IndianaAscension Saint Vincent Indianapolis Hospital, Indianapolis
Riley Hospital for Children, Indianapolis
IowaUI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny
Mercy Cancer Center-West Lakes, Clive
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive
Greater Regional Medical Center, Creston
Blank Children's Hospital, Des Moines
Iowa Methodist Medical Center, Des Moines
Mercy Medical Center - Des Moines, Des Moines
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee
Mercy Medical Center-West Lakes, West Des Moines
The Iowa Clinic PC, West Des Moines
KansasWesley Medical Center, Wichita
KentuckyUniversity of Kentucky/Markey Cancer Center, Lexington
Norton Children's Hospital, Louisville
LouisianaChildren's Hospital New Orleans, New Orleans
Ochsner Medical Center Jefferson, New Orleans
University Medical Center New Orleans, New Orleans
MaineEastern Maine Medical Center, Bangor
MaineHealth Maine Medical Center - Portland, Portland
Maine Children's Cancer Program, Scarborough
MaineHealth Maine Medical Center- Scarborough, Scarborough
MarylandJohns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
Sinai Hospital of Baltimore, Baltimore
University of Maryland/Greenebaum Cancer Center, Baltimore
Walter Reed National Military Medical Center, Bethesda
MassachusettsDana-Farber Cancer Institute, Boston
Massachusetts General Hospital Cancer Center, Boston
Tufts Medical Center, Boston
Baystate Medical Center, Springfield
UMass Memorial Medical Center - University Campus, Worcester
MichiganC S Mott Children's Hospital, Ann Arbor
University of Michigan Rogel Cancer Center, Ann Arbor
Bronson Battle Creek, Battle Creek
Children's Hospital of Michigan, Detroit
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
Trinity Health Grand Rapids Hospital, Grand Rapids
Beacon Kalamazoo, Kalamazoo
Bronson Methodist Hospital, Kalamazoo
West Michigan Cancer Center, Kalamazoo
Trinity Health Muskegon Hospital, Muskegon
Corewell Health Lakeland Hospitals - Niles Hospital, Niles
Corewell Health Reed City Hospital, Reed City
Corewell Health Children's, Royal Oak
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph
Munson Medical Center, Traverse City
University of Michigan Health - West, Wyoming
MinnesotaChildren's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis
University of Minnesota/Masonic Cancer Center, Minneapolis
Mayo Clinic in Rochester, Rochester
MississippiUniversity of Mississippi Medical Center, Jackson
MissouriMercy Cancer Center - Cape Girardeau, Cape Girardeau
Saint Francis Medical Center, Cape Girardeau
University of Missouri Children's Hospital, Columbia
Parkland Health Center - Farmington, Farmington
Children's Mercy Hospitals and Clinics, Kansas City
Lake Regional Hospital, Osage Beach
Sainte Genevieve County Memorial Hospital, Sainte Genevieve
Mercy Hospital Saint Louis, St Louis
Missouri Baptist Medical Center, St Louis
Washington University School of Medicine, St Louis
Missouri Baptist Sullivan Hospital, Sullivan
MontanaSaint Patrick Hospital - Community Hospital, Missoula
NebraskaChildren's Hospital and Medical Center of Omaha, Omaha
University of Nebraska Medical Center, Omaha
NevadaCarson Tahoe Regional Medical Center, Carson City
Comprehensive Cancer Centers of Nevada - Henderson, Henderson
Comprehensive Cancer Centers of Nevada-Horizon Ridge, Henderson
Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson
Urology Specialists of Nevada - Green Valley, Henderson
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas
Comprehensive Cancer Centers of Nevada, Las Vegas
Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas
Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas
Comprehensive Cancer Centers of Nevada - Town Center, Las Vegas
Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas
Hope Cancer Care of Nevada, Las Vegas
OptumCare Cancer Care at Charleston, Las Vegas
OptumCare Cancer Care at Fort Apache, Las Vegas
OptumCare Cancer Care at MountainView, Las Vegas
Radiation Oncology Centers of Nevada Central, Las Vegas
Radiation Oncology Centers of Nevada Southeast, Las Vegas
Summerlin Hospital Medical Center, Las Vegas
Sunrise Hospital and Medical Center, Las Vegas
University Medical Center of Southern Nevada, Las Vegas
Urology Specialists of Nevada - Central, Las Vegas
Urology Specialists of Nevada - Northwest, Las Vegas
Urology Specialists of Nevada - Southwest, Las Vegas
Women's Cancer Center of Nevada, Las Vegas
Hope Cancer Care of Nevada-Pahrump, Pahrump
Renown Regional Medical Center, Reno
Saint Mary's Regional Medical Center, Reno
New HampshireDartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
New JerseyHackensack University Medical Center, Hackensack
Morristown Medical Center, Morristown
Jersey Shore Medical Center, Neptune City
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick
Saint Peter's University Hospital, New Brunswick
Newark Beth Israel Medical Center, Newark
Saint Joseph's Regional Medical Center, Paterson
New MexicoPresbyterian Hospital, Albuquerque
University of New Mexico Cancer Center, Albuquerque
New YorkAlbany Medical Center, Albany
Maimonides Medical Center, Brooklyn
Roswell Park Cancer Institute, Buffalo
NYU Langone Hospital - Long Island, Mineola
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
Memorial Sloan Kettering Cancer Center, New York
Mount Sinai Hospital, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York
Stony Brook University Medical Center, Stony Brook
State University of New York Upstate Medical University, Syracuse
Children's Hospital at Montefiore, The Bronx
Montefiore Medical Center - Moses Campus, The Bronx
Montefiore Medical Center-Einstein Campus, The Bronx
Montefiore Medical Center-Weiler Hospital, The Bronx
New York Medical College, Valhalla
North CarolinaMission Hospital, Asheville
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
Carolinas Medical Center/Levine Cancer Institute, Charlotte
Novant Health Presbyterian Medical Center, Charlotte
Southeastern Medical Oncology Center-Clinton, Clinton
Southeastern Medical Oncology Center-Goldsboro, Goldsboro
East Carolina University, Greenville
Southeastern Medical Oncology Center-Jacksonville, Jacksonville
Wake Forest University Health Sciences, Winston-Salem
North DakotaSanford Broadway Medical Center, Fargo
OhioChildren's Hospital Medical Center of Akron, Akron
OhioHealth O'Bleness Hospital, Athens
Strecker Cancer Center-Belpre, Belpre
Adena Regional Medical Center, Chillicothe
Cincinnati Children's Hospital Medical Center, Cincinnati
Case Western Reserve University, Cleveland
Cleveland Clinic Foundation, Cleveland
Rainbow Babies and Childrens Hospital, Cleveland
Columbus Oncology and Hematology Associates Inc, Columbus
Doctors Hospital, Columbus
Grant Medical Center, Columbus
Mount Carmel East Hospital, Columbus
Mount Carmel Health Center West, Columbus
Nationwide Children's Hospital, Columbus
Ohio State University Comprehensive Cancer Center, Columbus
Riverside Methodist Hospital, Columbus
The Mark H Zangmeister Center, Columbus
Dayton Children's Hospital, Dayton
Delaware Health Center-Grady Cancer Center, Delaware
Grady Memorial Hospital, Delaware
Columbus Oncology and Hematology Associates, Dublin
Dublin Methodist Hospital, Dublin
Mount Carmel Grove City Hospital, Grove City
Saint Rita's Medical Center, Lima
OhioHealth Mansfield Hospital, Mansfield
Marietta Memorial Hospital, Marietta
OhioHealth Marion General Hospital, Marion
Memorial Hospital, Marysville
Knox Community Hospital, Mount Vernon
Licking Memorial Hospital, Newark
Mercy Health - Perrysburg Hospital, Perrysburg
OhioHealth Pickerington Methodist Hospital, Pickerington
Southern Ohio Medical Center, Portsmouth
ProMedica Flower Hospital, Sylvania
Mercy Health - Saint Anne Hospital, Toledo
Mercy Health - Saint Vincent Hospital, Toledo
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
OhioHealth Westerville Medical Campus/Westerville Cancer Center, Westerville
Saint Ann's Hospital, Westerville
Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center, Wilmington
Genesis Healthcare System Cancer Care Center, Zanesville
OklahomaCancer Centers of Southwest Oklahoma Research, Lawton
University of Oklahoma Health Sciences Center, Oklahoma City
Saint Francis Children's Hospital, Tulsa
OregonSaint Charles Health System, Bend
Clackamas Radiation Oncology Center, Clackamas
Bay Area Hospital, Coos Bay
Providence Newberg Medical Center, Newberg
Providence Willamette Falls Medical Center, Oregon City
Legacy Emanuel Children's Hospital, Portland
Oregon Health and Science University, Portland
Providence Portland Medical Center, Portland
Providence Saint Vincent Medical Center, Portland
PennsylvaniaLehigh Valley Hospital-Cedar Crest, Allentown
Geisinger Medical Center, Danville
Penn State Children's Hospital, Hershey
Children's Hospital of Philadelphia, Philadelphia
Saint Christopher's Hospital for Children, Philadelphia
University of Pennsylvania/Abramson Cancer Center, Philadelphia
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
UPMC Hillman Cancer Center, Pittsburgh
UPMC-Magee Womens Hospital, Pittsburgh
Rhode IslandRhode Island Hospital, Providence
South CarolinaPrisma Health Cancer Institute - Spartanburg, Boiling Springs
Medical University of South Carolina, Charleston
Prisma Health Richland Hospital, Columbia
Gibbs Cancer Center-Gaffney, Gaffney
BI-LO Charities Children's Cancer Center, Greenville
Prisma Health Cancer Institute - Butternut, Greenville
Prisma Health Cancer Institute - Eastside, Greenville
Prisma Health Cancer Institute - Faris, Greenville
Saint Francis Cancer Center, Greenville
Saint Francis Hospital, Greenville
Gibbs Cancer Center-Pelham, Greer
Prisma Health Cancer Institute - Greer, Greer
Prisma Health Cancer Institute - Seneca, Seneca
North Grove Medical Park, Spartanburg
Spartanburg Medical Center, Spartanburg
Spartanburg Medical Center - Mary Black Campus, Spartanburg
SMC Center for Hematology Oncology Union, Union
South DakotaSanford USD Medical Center - Sioux Falls, Sioux Falls
TennesseeT C Thompson Children's Hospital, Chattanooga
East Tennessee Childrens Hospital, Knoxville
Saint Jude Children's Research Hospital, Memphis
The Children's Hospital at TriStar Centennial, Nashville
Vanderbilt University/Ingram Cancer Center, Nashville
TexasDell Children's Medical Center of Central Texas, Austin
Driscoll Children's Hospital, Corpus Christi
Medical City Dallas Hospital, Dallas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
El Paso Children's Hospital, El Paso
Cook Children's Medical Center, Fort Worth
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
UT MD Anderson Cancer Center, Houston
Covenant Children's Hospital, Lubbock
UMC Cancer Center / UMC Health System, Lubbock
Children's Hospital of San Antonio, San Antonio
Methodist Children's Hospital of South Texas, San Antonio
University Hospital, San Antonio
University of Texas Health Science Center at San Antonio, San Antonio
Scott and White Memorial Hospital, Temple
VermontUniversity of Vermont and State Agricultural College, Burlington
VirginiaUniversity of Virginia Cancer Center, Charlottesville
Children's Hospital of The King's Daughters, Norfolk
Naval Medical Center - Portsmouth, Portsmouth
VCU Massey Comprehensive Cancer Center, Richmond
Carilion Children's, Roanoke
WashingtonProvidence Regional Cancer System-Aberdeen, Aberdeen
PeaceHealth Saint Joseph Medical Center, Bellingham
Providence Regional Cancer System-Centralia, Centralia
Swedish Cancer Institute-Edmonds, Edmonds
Providence Regional Cancer Partnership, Everett
Swedish Cancer Institute-Issaquah, Issaquah
Kadlec Clinic Hematology and Oncology, Kennewick
Providence Regional Cancer System-Lacey, Lacey
PeaceHealth Saint John Medical Center, Longview
Seattle Children's Hospital, Seattle
Swedish Medical Center-Ballard Campus, Seattle
Swedish Medical Center-Cherry Hill, Seattle
Swedish Medical Center-First Hill, Seattle
Providence Sacred Heart Medical Center and Children's Hospital, Spokane
Madigan Army Medical Center, Tacoma
Mary Bridge Children's Hospital and Health Center, Tacoma
Providence Saint Mary Regional Cancer Center, Walla Walla
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima
West VirginiaWest Virginia University Charleston Division, Charleston
Edwards Comprehensive Cancer Center, Huntington
West Virginia University Healthcare, Morgantown
WisconsinGreen Bay Oncology at Saint Vincent Hospital, Green Bay
Saint Vincent Hospital Cancer Center Green Bay, Green Bay
Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
Marshfield Medical Center-Marshfield, Marshfield
Children's Hospital of Wisconsin, Milwaukee
Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls
HSHS Saint Nicholas Hospital, Sheboygan
Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.