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Glioblastoma clinical trials in California
43 studies for Glioblastoma are looking for participants at sites in California.
Cities in California
- Los Angeles23 studies
- San Francisco19 studies
- Baldwin Park11 studies
- San Diego7 studies
- Orange6 studies
- Mountain View6 studies
- Irvine5 studies
- Sacramento4 studies
Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII
- UCSD Moores Cancer Center, La Jolla
- Cedars-Sinai Medical Center, Los Angeles
- UC Irvine Health, Orange
- and 1 more
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07326566A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors
- City of Hope - Duarte Cancer Center, Duarte
- UCLA Health Bowyer Oncology Center, Los Angeles
- UCSF Helen Diller Medical Center at Parnassus Heights - Neurology, San Francisco
- and 1 more
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06914128A Phase I Clinical Study of YN003 in the Treatment of Glioma
- University of California, Los Angeles (UCLA), Los Angeles
- University of California, San Francisco (UCSF), San Francisco
RecruitingPhase 1
Ages 18 to 70 · All sexes · Updated Nov 10, 2026 · NCT07929909Beginning Radiation Immediately With GammaTile at GBM Excision Versus Standard of Care
- Keck Medicine of USC, Los Angeles
- Cedars Sinai Medical Center, Los Angeles
- Sutter Health, San Francisco
- and 1 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 9, 2026 · NCT07195591Investigating the Feasibility and Acceptability of an Innovative Interdisciplinary Supportive Care Program: Couples Coping Together Against Cancer
- City of Hope Medical Center, Duarte
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 9, 2026 · NCT07664579Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment
- City of Hope Comprehensive Cancer Center, Duarte
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
- UC San Diego Moores Cancer Center, La Jolla
- and 5 more
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 9, 2026 · NCT05432804Multiple Intracerebral Doses of Neural Stem Cell-Based Virotherapy (NSC-CRAd-S-pk7) for the Treatment of Recurrent High-Grade Gliomas
- City of Hope Medical Center, Duarte
- Standford University, Stanford
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT05139056A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma
- Stanford University, Palo Alto
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07464925A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma
- University of California, San Diego, La Jolla
- St. Joseph Hospital, Orange
- University of California, San Francisco, San Francisco
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT03970447Tear Fluid for the Detection of Tumor-associated Extracellular Vesicles in Glioblastoma Patients
- City of Hope Medical Center, Duarte
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT07775534A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM
- University of California San Diego, San Diego
- University of California San Francisco, San Francisco
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT05303467Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas
- City of Hope Medical Center, Duarte
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 23, 2026 · NCT07544992Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma
- City of Hope Medical Center, Duarte
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 22, 2026 · NCT06815029Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma
- City of Hope Comprehensive Cancer Center, Duarte
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
- UC San Diego Moores Cancer Center, La Jolla
- and 2 more
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 21, 2026 · NCT06860594Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss
- University of California, Irvine, Irvine
- University of California Los Angeles, Los Angeles
- University of California at San Francisco, San Francisco
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 21, 2026 · NCT06810544SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)
- University of California San Diego, La Jolla
- University of California, Los Angeles, Los Angeles
- Hoag Memorial Hospital Presbyterian, Newport Beach
- and 2 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 19, 2026 · NCT05303519Biologic Association Between Metabolic Magnetic Resonance-positron Emission Tomograph (MR-PET) and Tissue Measures of Glycolysis in Brain Tumors of Infiltrating Glioblastoma Cells
- University of California at Los Angeles, Los Angeles
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 8, 2026 · NCT06059690Laser Interstitial Thermal Therapy (LITT) and Lomustine (CCNU) for Recurrent Glioblastoma
- University of California Davis Comprehensive Cancer Center, Sacramento
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07145112A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations
- Children's Hospital Los Angeles, Los Angeles
- University of California at Los Angeles, Los Angeles
RecruitingPhase 1/2
Up to age 25 · All sexes · Updated Sep 25, 2026 · NCT04094610Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
- Precision NextGen Oncology, Beverly Hills
- OPN Healthcare, Inc, Glendale
- University of Southern California, Los Angeles
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06047379Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma
- Cedars-Sinai Medical Center, Los Angeles
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT04977375ERAS-801 for the Treatment of Resectable and Progressive or Recurrent or Elderly Newly Diagnosed IDH Wildtype Grade IV Glioblastoma or Gliosarcoma With an EGFR Amplification or Mutation, ERAS801-SARG Trial
- UCLA / Jonsson Comprehensive Cancer Center, Los Angeles
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07089641Temporally-Modulated Pulsed Radiation Therapy Versus Standard Radiation Therapy for the Treatment of Newly Diagnosed, IDH Wildtype, MGMT-Unmethylated Glioblastoma
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
- USC / Norris Comprehensive Cancer Center, Los Angeles
- UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
- and 1 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07452458Study of ABBV-637 or ABBV-155 With ERAS-801 for People With Glioblastoma
- University of California, Los Angeles (Data Collection Only), Los Angeles
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06934889Identifying Findings on Brain Scans That Could Help Make Better Predictions About Brain Cancer Progression, The GABLE Trial
- Cedars-Sinai Medical Center, Los Angeles
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT06319027Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13Ralpha2 CAR (E-SYNC) T Cells
- University of California, San Francisco, San Francisco
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 13, 2026 · NCT06186401A Phase 2 Study of the Ketogenic Diet vs Standard Anti-cancer Diet Guidance for Patients With Glioblastoma in Combination With Standard-of-care Treatment
- Cedars-Sinai Medical Center, Los Angeles
- University of California, San Francisco, San Francisco
- Pacific Neuroscience Institute / Saint John's Cancer Institute, Santa Monica
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT05708352A Multicenter Trial to Identify Optimal Atezolizumab Biomarkers in the Setting of Recurrent Glioblastoma. The MOAB Trial
- University of California, San Francisco, San Francisco
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT06069726DOC1021 Dendritic Cell Immunotherapy for Treatment of Newly Diagnosed Adult Glioblastoma (GBM)
- City of Hope, Duarte
- HOAG, Newport Beach
- UCSF, San Francisco
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 1, 2026 · NCT06805305A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies
- University of California, Los Angeles (UCLA) Department of Medicine - Hematology/Oncology, Los Angeles
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT04678648ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors
- University of California, San Francisco, San Francisco
RecruitingPhase 1
Ages 2 to 21 · All sexes · Updated Jun 11, 2026 · NCT04732065PH Sensitive MRI Based Resections of Glioblastoma
- Ronald Reagan Medical Center, Los Angeles
RecruitingPhase 1
Ages 18 and older · All sexes · Updated May 4, 2026 · NCT06176066Comparative Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With Cancer
- Beckman Research Institute of City of Hope, Duarte
- VA Medical Center, Fresno, Fresno
- Santa Clara Valley Medical Center, Fruitdale
- and 5 more
Recruiting
Ages 18 and older · All sexes · Updated Apr 30, 2026 · NCT05297734Advanced Imaging Techniques for Evaluating the Tumor Immune Microenvironment in Glioblastoma Patients
- UCLA / Jonsson Comprehensive Cancer Center, Los Angeles
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Mar 10, 2026 · NCT07461948Magnetic Resonance Imaging for Improving Knowledge of Brain Tumor Biology in Patients With Resectable Glioblastoma
- UCLA / Jonsson Comprehensive Cancer Center, Los Angeles
Recruiting
Ages 18 and older · All sexes · Updated Nov 10, 2025 · NCT06090903SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
- Massive Bio SYNERGY-AI site, Duarte
- Massive Bio SYNERGY-AI site, Irvine
- Massive Bio SYNERGY-AI site, La Jolla
- and 3 more
RecruitingObservational study
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors
- Cedars Sinai Medical Center, Los Angeles
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 24, 2025 · NCT05941507APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
- Cedars-Sinai Medical Center - Samuel Oschin Comprehensive Cancer Institute, Los Angeles
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jun 27, 2025 · NCT03175224The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302)
- University of California, San Francisco, San Francisco
RecruitingObservational study
Ages 18 to 90 · All sexes · Updated Feb 28, 2024 · NCT06283927The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201)
- University of California, San Francisco (UCSF), San Francisco
RecruitingObservational study
Ages 18 to 90 · All sexes · Updated Feb 22, 2024 · NCT06118723From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.