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Head and Neck Squamous Cell Carcinoma clinical trials in California
75 studies for Head and Neck Squamous Cell Carcinoma are looking for participants at sites in California.
Cities in California
- Los Angeles43 studies
- Baldwin Park19 studies
- San Diego16 studies
- San Francisco14 studies
- Santa Monica12 studies
- Irvine11 studies
- Mountain View10 studies
- Sacramento8 studies
- Orange7 studies
- Newport Beach5 studies
- Fullerton3 studies
- Santa Rosa3 studies
Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma
- Kaiser Permanente-Anaheim, Anaheim
- Kaiser Permanente-Bellflower, Bellflower
- Kaiser Permanente Los Angeles Medical Center, Los Angeles
- and 1 more
RecruitingPhase 2
Ages 18 to 79 · All sexes · Updated Nov 12, 2026 · NCT04671667BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study
- Tower Cancer Research Foundation, Beverly Hills
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
- The Angeles Clinic and Research Institute - West Los Angeles Office, Los Angeles
- and 4 more
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT05136196Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment
- VA Palo Alto Health Care System, Palo Alto
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06589804A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types
- City of Hope Comprehensive Cancer Center, Duarte
- City of Hope Orange County Lennar Foundation Cancer Center, Irvine
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07503808Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
- Oncura Health, Glendale
- UC San Diego Health - Moores Cancer Center, La Jolla
- California Research Institute, Los Angeles
- and 4 more
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT04198766A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
- City of Hope National Medical Center, Duarte
- City of Hope at Irvine Lennar, Irvine
- Administrative Address: UCLA Hematology/Oncology, Los Angeles
- and 3 more
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07090499A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
- City of Hope National Medical Center, Duarte
- University of California, San Diego (UCSD) - Moores Cancer Center, La Jolla
- UCLA Department of Medicine-Hematology/Oncology, Los Angeles
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06465069A Phase 1 of CTX-8371 in Patients With Advanced Malignancies
- Stanford Cancer Institute, Palo Alto
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06150664High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer
- AIS Cancer Center at San Joaquin Community Hospital, Bakersfield
- Los Angeles General Medical Center, Los Angeles
- USC / Norris Comprehensive Cancer Center, Los Angeles
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06992427VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma
- Providence Medical Foundation (site 209), Santa Rosa
RecruitingPhase 1/2
Ages 18 to 80 · All sexes · Updated Nov 4, 2026 · NCT03556228A Study of JNJ-90301900 in Combination With Chemoradiation Therapy in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma
- City of Hope, Duarte
RecruitingPhase 1
Ages 18 to 74 · All sexes · Updated Nov 3, 2026 · NCT07219212A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer
- Providence St Jude Medical Center, Fullerton
- Scripps Health, La Jolla
- Valkyrie Clinical Trials, Los Angeles
- and 5 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07276399JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC
- City of Hope, Duarte
- University of California at San Diego Moores Cancer Center, La Jolla
- UCLA Hematology Oncology, Los Angeles
- and 1 more
RecruitingPhase 3
Ages 60 and older · All sexes · Updated Nov 3, 2026 · NCT04892173A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
- UCSD, La Jolla
- Sharp Healthcare, San Diego
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT03526835FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
- UC San Diego Moores Cancer Center (Site #0107), La Jolla
- UCLA Department of Medicine - Hematology/Oncology (Site #0106), Los Angeles
- UC Davis (Site#0144), Sacramento
- and 2 more
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Oct 29, 2026 · NCT06788990DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors
- USA06-0, Los Angeles
- USA16-0, Los Angeles
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 29, 2026 · NCT06953089Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma
- City of Hope Comprehensive Cancer Center, Duarte
- City of Hope at Irvine Lennar, Irvine
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 29, 2026 · NCT07156227A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations
- City of Hope, Duarte
- City of Hope, Irvine, Irvine
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT07109726Ordastobart (INBRX-106) Add-on to Pembrolizumab in 1L HPV+ PD-L1+ R/M OPSCC (HexAgon-HN)
- City of Hope Medical Center, Duarte
- Los Angeles Cancer Network (LACN), Los Angeles
- Medical Oncology Associates of San Diego, San Diego
- and 1 more
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT06295731A Study of MGC026 in Participants With Advanced Solid Tumors
- The Angeles Clinic and Research Institute, Los Angeles
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT06242470A Study to Investigate ALE.P02 as a Monotherapy or in Combination With Pembrolizumab in Adult Patients With Selected CLDN1+ Solid Tumors
- Providence Medical Foundation, Fullerton
- USC Norris Comprehensive Cancer Center, Los Angeles
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT06747585A Study to Assess Adverse Events, Change in Disease Activity and Optimal Dose of Intravenous (IV) Telisotuzumab Adizutecan With IV Pembrolizumab for First-Line Treatment of Adult Participants With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
- City Of Hope Comprehensive Cancer Center /ID# 281939, Duarte
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT07744126A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
- Los Angeles Cancer Network, Los Angeles
- Pih Health Hematology Medical Oncology, Whittier
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 26, 2026 · NCT06330064Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
- Los Angeles General Medical Center, Los Angeles
- USC / Norris Comprehensive Cancer Center, Los Angeles
- and 1 more
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 26, 2026 · NCT06980038A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
- University of California Los Angeles, Los Angeles
- Samuel Oschin Cancer Center, Los Angeles
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 22, 2026 · NCT06769698Intratumoral N17350 in Advanced Solid Tumors
- The Angeles Clinic and Research Institute, Los Angeles
- UCLA - Jonsson Comprehensive Cancer Center, Los Angeles
- Scripps Clinic Torrey Pines - La Jolla, San Diego
- and 1 more
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 21, 2026 · NCT07339176A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors
- Research Site 125, Los Angeles
- Research Site 133, Los Angeles
- Research Site 103, Los Angeles
- and 1 more
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 21, 2026 · NCT05914116SMP-3124LP in Adults With Advanced Solid Tumors
- Cedars Sinai Medical Center, Los Angeles
- University of California, San Francisco, San Francisco
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 15, 2026 · NCT06526819Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400
- City of Hope National Medical Center /ID# 258645, Duarte
- UCSF Medical Center - Mount Zion /ID# 257705, San Francisco
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 14, 2026 · NCT06084481A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC
- Site 105 - START Los Angeles, Los Angeles
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 14, 2026 · NCT07462377Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors
- Hoag Memorial Hospital Presbyterian, Newport Beach
- UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 13, 2026 · NCT06993844A Study to Evaluate CRB-701 Compared to Investigator's Choice Therapy in Previously Treated Oropharyngeal Squamous Cell Carcinoma
- City of Hope Comprehensive Cancer Center, Duarte
- University of California Los Angeles Westwood Cancer Center, Los Angeles
- Stanford Medicine - Cancer Center, Palo Alto
- and 2 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 8, 2026 · NCT07768189Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
- Moores Cancer Center UC San Diego Health, La Jolla
- Keck School of Medicine of USC, Los Angeles
- UCLA, Los Angeles
- and 1 more
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 6, 2026 · NCT04429542Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
- Exelixis Clinical Site #59, Santa Barbara
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05176483A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors
- ALX Center 9, La Jolla
- ALX Center 11, Santa Monica
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07085091A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation
- Research Site, Duarte
- Research Site, Los Angeles
- Research Site, Newport Beach
- and 1 more
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT05877599Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
- Precision NextGen Oncology, Beverly Hills
- OPN Healthcare, Inc, Glendale
- University of Southern California, Los Angeles
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06047379A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors
- Kivu Trial Site, Santa Monica
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT07229313Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer
- Stanford University, Stanford
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT06736379Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors
- Beverly Hills Cancer Center, Beverly Hills
- City of Hope Cancer Center, Duarte
- University of California Irvine Medical Center, Orange
- and 1 more
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05983432From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.