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Head and Neck Squamous Cell Carcinoma clinical trials recruiting in the U.S.
177 studies for Head and Neck Squamous Cell Carcinoma are recruiting participants at sites across the United States.
Cities with the most studies
- Houston, TX46 studies
- Los Angeles, CA42 studies
- Boston, MA40 studies
- Nashville, TN39 studies
- New York City, NY39 studies
- St. Louis, MO28 studies
- Philadelphia, PA26 studies
- Chicago, IL25 studies
- Arlington, VA25 studies
- Atlanta, GA23 studies
- Pittsburgh, PA22 studies
- New Haven, CT22 studies
- San Antonio, TX22 studies
- Queens, NY20 studies
- Dallas, TX20 studies
- Portland, OR18 studies
- Columbus, OH18 studies
- Cleveland, OH18 studies
- Durham, NC17 studies
- Orlando, FL16 studies
- Edison, NJ15 studies
- Miami, FL15 studies
- Baltimore, MD15 studies
- Detroit, MI15 studies
- Grand Rapids, MI15 studies
- Tampa, FL15 studies
- Baldwin Park, CA15 studies
- Cincinnati, OH14 studies
- Charleston, SC14 studies
- San Diego, CA13 studies
- Milwaukee, WI13 studies
- Omaha, NE13 studies
- Oklahoma City, OK13 studies
- Richmond, VA12 studies
- Jacksonville, FL12 studies
- Santa Monica, CA12 studies
- Louisville, KY12 studies
- Cedar Rapids, IA12 studies
- Irvine, CA11 studies
- Washington, DC11 studies
By state
- Alabama7 studies
- Arizona18 studies
- Arkansas10 studies
- California70 studies
- Colorado23 studies
- Connecticut24 studies
- District of Columbia9 studies
- Florida54 studies
- Georgia24 studies
- Idaho4 studies
- Illinois29 studies
- Indiana13 studies
- Iowa14 studies
- Kansas9 studies
- Kentucky17 studies
- Louisiana6 studies
- Maryland18 studies
- Massachusetts42 studies
- Michigan35 studies
- Minnesota23 studies
- Missouri29 studies
- Montana5 studies
- Nebraska15 studies
- Nevada4 studies
- New Hampshire4 studies
- New Jersey25 studies
- New Mexico3 studies
- New York54 studies
- North Carolina27 studies
- North Dakota6 studies
- Ohio44 studies
- Oklahoma14 studies
- Oregon18 studies
- Pennsylvania41 studies
- Rhode Island7 studies
- South Carolina21 studies
- South Dakota9 studies
- Tennessee43 studies
- Texas68 studies
- Utah21 studies
- Vermont4 studies
- Virginia41 studies
- Washington19 studies
- Wisconsin15 studies
Recently updated studies
Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06980038A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07276399A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Head and Neck Cancer
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06385080JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC
RecruitingPhase 3
Ages 60 and older · All sexes · Updated Sep 25, 2026 · NCT04892173A Study of JNJ-90301900 in Combination With Chemoradiation Therapy in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma
RecruitingPhase 1
Ages 18 to 74 · All sexes · Updated Sep 25, 2026 · NCT07219212BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT05136196A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT07229313Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06047379Intratumoral N17350 in Advanced Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07339176Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma
RecruitingPhase 2
Ages 18 to 79 · All sexes · Updated Sep 22, 2026 · NCT04671667Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06589804Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05983432Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT06736379A Study of ASP388B Given by Itself and With Standard Therapies in Participants With Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07730021Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT05267626Pembrolizumab + N-803 Alone or in Combination With PD-L1 t-haNK Cells for Resectable Head and Neck Squamous Cell Carcinoma
RecruitingPhase 2
Ages 18 to 120 · All sexes · Updated Sep 18, 2026 · NCT06161545A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07109726Candida Therapeutic Vaccine in Head and Neck Cancer Patients to Reduce Recurrence
RecruitingPhase 2
Ages 18 to 100 · All sexes · Updated Sep 15, 2026 · NCT05952934Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT02734537ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT05059444Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION)
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT07513389Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06535607First in Human Study of TUB-030 in Patients With Advanced Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06657222A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07462377Anti-Ly6E Exatecan ADC M7437 in Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07360314From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.