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Headache clinical trials recruiting in the U.S.
39 studies for Headache are recruiting participants at sites across the United States.
Nearly everyone has had a headache, the most common form of pain. Learn the different types, the different symptoms of, and when to see a doctor.
By state
- California8 studies
- Florida4 studies
- Georgia3 studies
- Maryland5 studies
- New York8 studies
- North Carolina3 studies
- Ohio3 studies
- Pennsylvania3 studies
- Texas5 studies
- Washington3 studies
Recently updated studies
A Comparison of Nurtec ODT to Maxalt MLT-ODT in Adult ED Patients With Migraine Headache
RecruitingPhase 4
Ages 18 to 65 ยท All sexes ยท Updated Sep 24, 2026 ยท NCT06473597EMBRACE-OBS: Single-Site Observational Registry of Patient-Reported Outcomes Following MMA Embolization for Migraine
RecruitingObservational study
Ages 18 to 64 ยท All sexes ยท Updated Sep 23, 2026 ยท NCT07652034Localized Injection of Lidocaine Via the Middle Meningeal Artery for Headache Treatment
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 22, 2026 ยท NCT07361549Familial Mediterranean Fever and Related Disorders: Genetics and Disease Characteristics
RecruitingObservational studyHealthy volunteers welcome
2 Months โ 115 Years ยท All sexes ยท Updated Sep 22, 2026 ยท NCT00001373Multisite Advancement of Research on Chronic Posttraumatic Headache
Recruiting
Ages 18 to 70 ยท All sexes ยท Updated Sep 22, 2026 ยท NCT05620719Puberty, Testosterone, and Brain Development
RecruitingObservational study
Ages 12 to 20 ยท All sexes ยท Updated Sep 21, 2026 ยท NCT06670053Responding With Evidence and Access for Childhood Headaches
Recruiting
Ages 10 to 17 ยท All sexes ยท Updated Sep 21, 2026 ยท NCT05889624Tirzepatide in Idiopathic Intracranial Hypertension Trial
RecruitingPhase 4
Ages 18 to 60 ยท All sexes ยท Updated Sep 15, 2026 ยท NCT07191873Effect of Ultrasound-Guided Dry Needling Targeting Rectus Capitus Posterior Major on Individuals With Headaches
Recruiting
Ages 18 to 65 ยท All sexes ยท Updated Sep 9, 2026 ยท NCT07309874A Pivotal Clinical Study to Evaluate the MySalvia System for the Treatment of Resistant Migraine
Recruiting
Ages 22 to 84 ยท All sexes ยท Updated Aug 28, 2026 ยท NCT07719608Immediate Neuromuscular Responses of the Obliquus Capitis Inferior Following Upper Cervical Manual Therapy
RecruitingHealthy volunteers welcome
Ages 18 to 65 ยท All sexes ยท Updated Aug 28, 2026 ยท NCT07725198Assessment of the Efficacy of Medrol Dose Pack for Acute Post-Concussive Headaches
RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Aug 26, 2026 ยท NCT04685772Transnasal Sphenopalatine Ganglion Block for Treatment of Acute Subarachnoid Hemorrhage Associated Headache
RecruitingPhase 2/3
Ages 18 to 100 ยท All sexes ยท Updated Aug 18, 2026 ยท NCT06621329Headache Ear Auditory Dizziness Sinus (HEADS) Registry
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Aug 10, 2026 ยท NCT07754266Lidocaine Infusion Treatment for Subarachnoid Hemorrhage Headaches
RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Jul 10, 2026 ยท NCT06582810IA Lidocaine and Methylprednisolone for Headache Associated With Subarachnoid Hemorrhage
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Jul 8, 2026 ยท NCT07054801BLOCK-SAH - PPF-Block for Post-SAH Headache
RecruitingPhase 2
Ages 18 to 85 ยท All sexes ยท Updated Jul 6, 2026 ยท NCT06008795Chiropractic Care for Episodic Migraine
Recruiting
Ages 18 to 65 ยท All sexes ยท Updated Jun 26, 2026 ยท NCT06229834Placebo Impacts Sleep and Pain Modulation in Chronic Pain
Recruiting
Ages 18 to 88 ยท All sexes ยท Updated Jun 17, 2026 ยท NCT06225817An Open Label Study Assessing REN Treatment in Headache Management in Temporomandibular Disorders
Recruiting
Ages 12 and older ยท All sexes ยท Updated Jun 10, 2026 ยท NCT07639944Determining the Utility of a Behavioral Intervention in Chronic Migraine
Recruiting
Ages 18 and older ยท All sexes ยท Updated Jun 8, 2026 ยท NCT05415020Intranasal Sphenopalatine Ganglion Blockade for Headaches Following Aneurysmal Subarachnoid Hemorrhage
RecruitingPhase 4
Ages 18 and older ยท All sexes ยท Updated May 27, 2026 ยท NCT07116408Bilateral Middle Meningeal Artery Lidocaine Infusion for Chronic Debilitating Migraines
RecruitingPhase 2
Ages 18 to 75 ยท All sexes ยท Updated May 22, 2026 ยท NCT07061847External Trigeminal Nerve Stimulation for Migraine Treatment in Pregnancy
RecruitingObservational study
Ages 18 to 44 ยท Women ยท Updated Apr 15, 2026 ยท NCT06788977Machine Learning in Guiding rTMS Treatment for GWI-Related Headaches and Body Pain
Recruiting
Ages 18 to 65 ยท All sexes ยท Updated Apr 13, 2026 ยท NCT07325513From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.