Localized Injection of Lidocaine Via the Middle Meningeal Artery for Headache Treatment

Inclusion Criteria:

* Age 18 years or above
* Diagnosis of chronic migraine
* Referred for diagnostic cerebral angiography to screen for intracranial pathology
* Written informed consent able to be obtained from subject

Exclusion Criteria:

* Baseline HIT-6 score less than 50
* Pregnant, breastfeeding, or unwilling to practice contraception during participation in the study
* Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data
* Concomitant intracranial pathology (eg, intracranial malignancy)
* Known hypersensitivity and/or contraindication to lidocaine or local anesthetics of the amide type
* Taking chronic medications that, when co-administered with lidocaine and other local anesthetics, are at increased risk of developing methemoglobinemia (nitrates/nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, acetaminophen, metoclopramide, quinine, sulfasalazine)
* Known contraindications for angiography (eg, ESRD not requiring hemodialysis). Patients with contrast allergy with be premeditated with diphenhydramine and steroids.
* Contraindication to anesthetic agents used for conscious sedation/monitored anesthesia care (MAC)
* Concurrent participation in another research protocol for investigation of an experimental therapy
* Per DSA imaging, presence of a cerebrovascular pathology known to cause headache (eg, arteriovenous malformation, dural arteriovenous fistula)
* Per DSA imaging, presence of anastomosis or anatomical variation (eg, branches of middle meningeal artery) that could lead to increased procedural risk
* Per DSA imaging, lack of endovascular access to either middle meningeal artery, or origin of the middle meningeal artery other than from the external carotid artery
* Known or suspected inability to adhere to study protocol or protocol requirements, as per discretion of the Investigator or treating provider