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Hyperinsulinism clinical trials recruiting in the U.S.

12 studies for Hyperinsulinism are recruiting participants at sites across the United States.

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Recently updated studies

A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06881992

Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

RecruitingObservational studyHealthy volunteers welcome
Ages 7 to 70 · All sexes · Updated Sep 16, 2026 · NCT03374215

Graded Insulin Suppression Test P&F

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Sep 8, 2026 · NCT06592261

Alpelisib Challenge Test (ACT)

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 70 · All sexes · Updated Sep 3, 2026 · NCT07778524

Human Models of Selective Insulin Resistance: Alpelisib, Part I

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 70 · All sexes · Updated Aug 24, 2026 · NCT06354088

Effect of Insulin Lowering on Lipogenesis

RecruitingPhase 1
Ages 18 to 65 · All sexes · Updated Jul 6, 2026 · NCT07403604

Study to Evaluate Biomarkers and Safety of Dapagliflozin Concomitant With Neoadjuvant Therapy

RecruitingPhase 1
Ages 18 and older · Women · Updated May 22, 2026 · NCT05989347

Determinants of Insulin Sensitivity by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated May 1, 2026 · NCT05950282

Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/Her2- Breast Cancer

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Apr 22, 2026 · NCT05455619

Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

RecruitingHealthy volunteers welcome
Ages 12 to 17 · Women · Updated Apr 22, 2026 · NCT05543083

Utility of 18FDOPA PET/MRI for Focal Hyperinsulinism

RecruitingPhase 2
All ages · All sexes · Updated Dec 19, 2025 · NCT05088798

Fluorodopa F 18 in Congenital Hyperinsulinism and Insulinoma

RecruitingPhase 1
Up to age 18 · All sexes · Updated Jul 16, 2024 · NCT02021604

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.