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Idiopathic Hypersomnia clinical trials recruiting in the U.S.

10 studies for Idiopathic Hypersomnia are recruiting participants at sites across the United States.

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Recently updated studies

A Study of TAK-360 in People With Narcolepsy or Idiopathic Hypersomnia

RecruitingPhase 2/3
Ages 18 to 71 · All sexes · Updated Sep 18, 2026 · NCT07646678

A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Idiopathic Hypersomnia (IH)

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT07500090

A Study Evaluating the Efficacy and Safety of Xywav Expanded Dosing vs Placebo in Participants With Narcolepsy or IH

RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Aug 19, 2026 · NCT07625280

A Long-Term Study of ALKS 2680 in Subjects With Narcolepsy and Idiopathic Hypersomnia

RecruitingPhase 2/3
Ages 18 to 70 · All sexes · Updated Aug 7, 2026 · NCT06767683

A Study of TAK-360 in Adults With Idiopathic Hypersomnia

RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Jul 15, 2026 · NCT06812078

Effects of Operational Naps on Blood Pressure and Performance Among Night Shift Workers

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT07217769

Low Sodium Oxybate in Patients With Idiopathic Hypersomnia

RecruitingPhase 4
Ages 18 to 65 · All sexes · Updated May 12, 2026 · NCT05837091

A Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia

RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Apr 27, 2026 · NCT06752668

A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia

RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Apr 16, 2026 · NCT07096674

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

RecruitingObservational study
All ages · All sexes · Updated May 29, 2025 · NCT01793168

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.