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Immune System and Disorders clinical trials recruiting in the U.S.

46 studies for Immune System and Disorders are recruiting participants at sites across the United States.

Your immune system is made up of cells, tissues, and organs that fight infections and diseases. Learn how it works, and about diseases of the immune system.

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Recently updated studies

Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of Immunity

RecruitingPhase 2
Ages 4 to 69 · All sexes · Updated Nov 12, 2026 · NCT04339777

Genetic Analysis of Immune Disorders

RecruitingObservational study
1 Day – 101 Years · All sexes · Updated Nov 12, 2026 · NCT00001467

A Study to Learn About the Study Medicine Called Tilrekimig in People With Moderate-to-Severe Eczema

RecruitingPhase 3
Ages 12 and older · All sexes · Updated Nov 12, 2026 · NCT07765888

Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System

RecruitingObservational studyHealthy volunteers welcome
1 Month – 99 Years · All sexes · Updated Nov 12, 2026 · NCT00794352

Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)

RecruitingObservational studyHealthy volunteers welcome
1 Month – 120 Years · All sexes · Updated Nov 12, 2026 · NCT00006150

Detection and Characterization of Infections and Infection Susceptibility

RecruitingObservational study
1 Month – 100 Years · All sexes · Updated Nov 12, 2026 · NCT00404560

A Study to Learn About the Study Medicine Called Tilrekimig in People With Moderate-to Severe Eczema

RecruitingPhase 3
Ages 12 and older · All sexes · Updated Nov 6, 2026 · NCT07783425

Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies

RecruitingPhase 2Healthy volunteers welcome
Ages 4 to 75 · All sexes · Updated Nov 5, 2026 · NCT02579967

Collection of Research Data and Samples From Patients Treated With Immunotherapy to Study Its Side Effects

RecruitingObservational study
All ages · All sexes · Updated Nov 4, 2026 · NCT04242095

A Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06722235

A Phase 3 Blinded Study of JADE101 in Participants With Immunoglobulin A Nephropathy

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07902817

A Study of JADE101 in Participants With Immunoglobulin A Nephropathy

RecruitingPhase 2
Ages 18 to 60 · All sexes · Updated Oct 30, 2026 · NCT07541287

A Follow-up Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT06948318

Oral Bacteria and Immune System Problems Involved in Gum Disease (Periodontitis)

RecruitingObservational studyHealthy volunteers welcome
Ages 7 to 100 · All sexes · Updated Oct 26, 2026 · NCT01568697

Evaluation of ETHY-001 for Safety, Tolerability, and Clinical Activity in Thyroid Eye Disease

RecruitingPhase 1Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 26, 2026 · NCT07885605

BREATHE: An Efficacy-implementation Trial Among Black Adults With Uncontrolled Asthma

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 23, 2026 · NCT05341726

A First-in-Human Study of KK2223 in Participants With Relapsed or Refractory T Cell Non-Hodgkin Lymphoma

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07192471

Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia

RecruitingObservational study
Ages 1 to 100 · All sexes · Updated Sep 28, 2026 · NCT00001406

METabolic MODulation to Enhance Insulin Sensitivity and Mitochondrial Function in Type 1 Diabetes (MetMod-T1D)

RecruitingPhase 2
Ages 18 to 69 · All sexes · Updated Sep 15, 2026 · NCT07699380

(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT04996875

PS-002 for the Treatment of IgA Nephropathy in Adults

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07182227

A Study to Evaluate a Novel Gene Therapy in Patients With Relapsed and Refractory Multiple Myeloma

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT07075185

Study of Rondecabtagene Autoleucel in Aggressive Large B-Cell Lymphoma

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Aug 25, 2026 · NCT05826535

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.