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Immune System and Disorders clinical trials recruiting in the U.S.
46 studies for Immune System and Disorders are recruiting participants at sites across the United States.
Your immune system is made up of cells, tissues, and organs that fight infections and diseases. Learn how it works, and about diseases of the immune system.
Cities with the most studies
- Washington, DC13 studies
- New York City, NY12 studies
- Boston, MA10 studies
- Portland, OR10 studies
- Atlanta, GA10 studies
- Philadelphia, PA10 studies
- Houston, TX9 studies
- Los Angeles, CA9 studies
- Cleveland, OH8 studies
- Chicago, IL8 studies
- Seattle, WA6 studies
- Milwaukee, WI6 studies
- Tampa, FL6 studies
- Dallas, TX6 studies
- Cedar Rapids, IA6 studies
- Baldwin Park, CA5 studies
- Salt Lake City, UT5 studies
- Durham, NC5 studies
- Nashville, TN5 studies
- Pittsburgh, PA4 studies
- Phoenix, AZ4 studies
- Clifton, NJ4 studies
- Orlando, FL4 studies
- San Diego, CA4 studies
- St. Louis, MO4 studies
- Indianapolis, IN4 studies
- Omaha, NE3 studies
- Rochester, MN3 studies
- Buffalo, NY3 studies
- Denver, CO3 studies
- Fargo, ND3 studies
- Miami, FL3 studies
- Lewisville, TX3 studies
- Mountain View, CA3 studies
- Greenville, NC3 studies
- Richmond, VA3 studies
- Columbus, OH3 studies
- San Francisco, CA3 studies
- New Haven, CT3 studies
- Cincinnati, OH3 studies
By state
- Arizona5 studies
- Arkansas4 studies
- California19 studies
- Colorado5 studies
- Connecticut3 studies
- District of Columbia3 studies
- Florida13 studies
- Georgia13 studies
- Illinois10 studies
- Indiana4 studies
- Iowa6 studies
- Kentucky4 studies
- Maryland14 studies
- Massachusetts10 studies
- Michigan5 studies
- Minnesota4 studies
- Missouri6 studies
- Nebraska3 studies
- New Jersey6 studies
- New York15 studies
- North Carolina8 studies
- North Dakota3 studies
- Ohio9 studies
- Oregon10 studies
- Pennsylvania13 studies
- South Carolina3 studies
- Tennessee6 studies
- Texas17 studies
- Utah5 studies
- Virginia7 studies
- Washington7 studies
- Wisconsin6 studies
Recently updated studies
Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of Immunity
RecruitingPhase 2
Ages 4 to 69 · All sexes · Updated Nov 12, 2026 · NCT04339777Genetic Analysis of Immune Disorders
RecruitingObservational study
1 Day – 101 Years · All sexes · Updated Nov 12, 2026 · NCT00001467A Study to Learn About the Study Medicine Called Tilrekimig in People With Moderate-to-Severe Eczema
RecruitingPhase 3
Ages 12 and older · All sexes · Updated Nov 12, 2026 · NCT07765888Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System
RecruitingObservational studyHealthy volunteers welcome
1 Month – 99 Years · All sexes · Updated Nov 12, 2026 · NCT00794352Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)
RecruitingObservational studyHealthy volunteers welcome
1 Month – 120 Years · All sexes · Updated Nov 12, 2026 · NCT00006150Detection and Characterization of Infections and Infection Susceptibility
RecruitingObservational study
1 Month – 100 Years · All sexes · Updated Nov 12, 2026 · NCT00404560A Study to Learn About the Study Medicine Called Tilrekimig in People With Moderate-to Severe Eczema
RecruitingPhase 3
Ages 12 and older · All sexes · Updated Nov 6, 2026 · NCT07783425Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies
RecruitingPhase 2Healthy volunteers welcome
Ages 4 to 75 · All sexes · Updated Nov 5, 2026 · NCT02579967Collection of Research Data and Samples From Patients Treated With Immunotherapy to Study Its Side Effects
RecruitingObservational study
All ages · All sexes · Updated Nov 4, 2026 · NCT04242095A Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06722235A Phase 3 Blinded Study of JADE101 in Participants With Immunoglobulin A Nephropathy
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07902817A Study of JADE101 in Participants With Immunoglobulin A Nephropathy
RecruitingPhase 2
Ages 18 to 60 · All sexes · Updated Oct 30, 2026 · NCT07541287A Follow-up Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT06948318Oral Bacteria and Immune System Problems Involved in Gum Disease (Periodontitis)
RecruitingObservational studyHealthy volunteers welcome
Ages 7 to 100 · All sexes · Updated Oct 26, 2026 · NCT01568697Evaluation of ETHY-001 for Safety, Tolerability, and Clinical Activity in Thyroid Eye Disease
RecruitingPhase 1Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 26, 2026 · NCT07885605BREATHE: An Efficacy-implementation Trial Among Black Adults With Uncontrolled Asthma
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 23, 2026 · NCT05341726A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With Active, Pemphigus Vulgaris (RESET-PV)
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 15, 2026 · NCT04422912CA-4948-101: Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in Relapsed or Refractory Primary Central Nervous System Lymphoma (R/R PCNSL)
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 6, 2026 · NCT03328078A First-in-Human Study of KK2223 in Participants With Relapsed or Refractory T Cell Non-Hodgkin Lymphoma
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07192471Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia
RecruitingObservational study
Ages 1 to 100 · All sexes · Updated Sep 28, 2026 · NCT00001406METabolic MODulation to Enhance Insulin Sensitivity and Mitochondrial Function in Type 1 Diabetes (MetMod-T1D)
RecruitingPhase 2
Ages 18 to 69 · All sexes · Updated Sep 15, 2026 · NCT07699380(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT04996875PS-002 for the Treatment of IgA Nephropathy in Adults
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07182227A Study to Evaluate a Novel Gene Therapy in Patients With Relapsed and Refractory Multiple Myeloma
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT07075185Study of Rondecabtagene Autoleucel in Aggressive Large B-Cell Lymphoma
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Aug 25, 2026 · NCT05826535From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.