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Liver Cancer (Hepatocellular Carcinoma) clinical trials in Orange, CA

14 studies for Liver Cancer (Hepatocellular Carcinoma) are looking for participants at sites in and around Orange (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Study of the Theranostic Pair RYZ811 (Diagnostic) and RYZ801 (Therapeutic) to Identify and Treat Subjects With GPC3+ (Glypican-3) Unresectable HCC

RecruitingPhase 1/2
  • Research Facility, Orange
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06726161

Visugromab, Nivolumab and Lenvatinib Compared to Double Placebo and Lenvatinib in Unresectable or Metastatic Hepatocellular Carcinoma Post Anti-PD-(L)1 Failure

RecruitingPhase 2
  • UC Irvine Health. Chao Family Comprehensive Cancer Center, Orange
Ages 18 to 100 · All sexes · Updated Sep 23, 2026 · NCT07219459

Testing the Addition of an Anti-cancer Drug, Sapanisertib, to the Usual Chemotherapy Treatment (Cabozantinib) in Metastatic Liver Cell Cancer With a Change in Genes for the Protein β-Catenin, The SAPHIRE Trial

RecruitingPhase 1/2
  • UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06811116

Pilot Comparing ctDNA IDV vs. SPV Sample in Pts Undergoing Biopsies for Hepatobiliary and Pancreatic Cancers

Recruiting
  • Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange
Ages 18 and older · All sexes · Updated Aug 31, 2026 · NCT05497531

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

RecruitingPhase 1/2
  • Children's Hospital of Orange County, Orange
12 Months – 30 Years · All sexes · Updated Aug 25, 2026 · NCT04851119

Patient-Derived Xenografts to Reduce Cancer Health Disparities

RecruitingObservational study
  • UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Ages 21 to 100 · All sexes · Updated Aug 20, 2026 · NCT04410302

Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients With Advanced Liver Cancer, HELIO-RT Trial

RecruitingPhase 3
  • UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT07166406

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

RecruitingPhase 1
  • UC Irvine Health - Chao Family Comprehensive Cancer Center, Orange
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT05208762

ET140203 T Cells in Pediatric Subjects With Hepatoblastoma, HCN-NOS, or Hepatocellular Carcinoma

RecruitingPhase 1/2
  • Children's Hospital Orange County, Orange
Ages 1 to 21 · All sexes · Updated Jul 6, 2026 · NCT04634357

Cabozantinib Combined With Ipilimumab/Nivolumab and TACE in Patients With Hepatocellular Carcinoma

RecruitingPhase 2
  • Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange
Ages 18 and older · All sexes · Updated Jul 1, 2026 · NCT04472767

A Study of TTI-101 as Monotherapy and in Combination in Participants With Locally Advanced or Metastatic, and Unresectable Hepatocellular Carcinoma

RecruitingPhase 1/2
  • University of California Irvine Medical Center, Orange
Ages 18 and older · All sexes · Updated Apr 27, 2026 · NCT05440708

Combination of TATE and PD-1 Inhibitor in Liver Cancer

RecruitingPhase 2
  • University of California, Irvine, Orange
Ages 18 to 80 · All sexes · Updated Apr 16, 2026 · NCT03259867

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Orange
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Liver Cancer (Hepatocellular Carcinoma) trials in other cities

Other studies in Orange

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.