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Melanoma clinical trials in Orange, CA

14 studies for Melanoma are looking for participants at sites in and around Orange (within about 30 miles). Open a study to see who can join and how to contact the study team.

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

RecruitingPhase 2
  • UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT05136196

A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)

RecruitingPhase 3
  • St. Joseph Hospital Orange, Orange
  • University of California Irvine, UCI Medical Center, Orange
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06246916

Comparing the Effectiveness of Less Invasive Procedures With the Current Standard of Care for the Treatment of Older Adults With Early-Stage Melanoma

RecruitingPhase 3
  • UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Ages 75 and older · All sexes · Updated Sep 24, 2026 · NCT07068074

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

RecruitingPhase 1/2
  • Children's Hospital of Orange County, Orange
12 Months – 30 Years · All sexes · Updated Aug 25, 2026 · NCT04851119

Project: Every Child for Younger Patients With Cancer

RecruitingObservational study
  • Children's Hospital of Orange County, Orange
Up to age 25 · All sexes · Updated Aug 25, 2026 · NCT02402244

Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors

RecruitingEarly phase 1
  • Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT07628634

Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

RecruitingPhase 2
  • Chao Family Comprehensive Cancer Center, University of California Irvine, Orange
Ages 18 and older · All sexes · Updated Jul 14, 2026 · NCT06580002

MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma

RecruitingPhase 1/2
  • University of California Irvine, Orange
Ages 18 to 90 · All sexes · Updated Jun 10, 2026 · NCT05655312

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

RecruitingPhase 1/2
  • UC Irvine/Chao Family Comprehensive Cancer Center, Orange
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT05379985

Neoadjuvant Darovasertib in Primary Uveal Melanoma

RecruitingPhase 3
  • University of California Irvine Medical Center, Orange
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT07015190

A Study of VET3-TGI in Patients With Solid Tumors

RecruitingPhase 1
  • UC Irvine Health, Orange
Ages 18 and older · All sexes · Updated Apr 7, 2026 · NCT06444815

Metronomic Cyclophosphamide With Pembrolizumab in Checkpoint Inhibitor Refractory Melanoma

RecruitingPhase 2
  • Chao Family Comprehensive Cancer Center University of California, Irvine, Orange
Ages 18 and older · All sexes · Updated Mar 10, 2026 · NCT06771544

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Orange
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

Recruiting
  • UC Irvine Health - Chao Family Comprehensive Cancer Center, Orange
  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Orange
Ages 18 and older · All sexes · Updated Nov 27, 2024 · NCT03860883

About Melanoma

Melanoma is the most serious type of skin cancer. Most have a black or black-blue area. Learn the 'ABCDE' of what to watch for and treatment options.

More about Melanoma on MedlinePlus

Melanoma trials in other cities

Other studies in Orange

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.