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Liver Diseases clinical trials recruiting in the U.S.

33 studies for Liver Diseases are recruiting participants at sites across the United States.

Get the facts about liver diseases, such as hepatitis, cancer, and cirrhosis. Know your risk and what you can do to prevent liver problems.

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Recently updated studies

Evaluation of Patients With Liver Disease

RecruitingObservational studyHealthy volunteers welcome
Ages 2 to 100 · All sexes · Updated Sep 24, 2026 · NCT00001971

Study of AHB-137 in Chronic Hepatitis B (CHB) Participants in North America and Europe Regions

RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Sep 24, 2026 · NCT07654283

Natural History of Noncirrhotic Portal Hypertension

RecruitingObservational study
Ages 12 to 100 · All sexes · Updated Sep 22, 2026 · NCT02417740

Unraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative Research Approach

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 90 · All sexes · Updated Sep 22, 2026 · NCT04685200

Study of Resmetirom in Children and Adolescents With MASH

RecruitingPhase 2
Ages 6 to 17 · All sexes · Updated Sep 11, 2026 · NCT07763015

Observational Pharmaco-Epidemiology Research & Analysis

RecruitingObservational studyHealthy volunteers welcome
Ages 0 and older · All sexes · Updated Sep 11, 2026 · NCT03813862

A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH

RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Sep 3, 2026 · NCT06419374

A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)

RecruitingPhase 3
Ages 18 to 80 · All sexes · Updated Sep 3, 2026 · NCT06318169

Long-term Follow-up (LTFU) Study of Participants in Any iECURE Protocol Using an Investigational Product (IP)

RecruitingObservational study
7 Months – 15 Months · All sexes · Updated Aug 31, 2026 · NCT06805695

An Open-label Study to Investigate ECUR-506 in Male Babies Less Than 9 Months of Age With Neonatal Onset OTC Deficiency

RecruitingPhase 3
24 Hours – 7 Months · Men · Updated Aug 12, 2026 · NCT06255782

Development and Testing of a Patient-facing Educational Tool About Liver Cancer Prevention

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT07010315

Primary Sclerosing Cholangitis in Children

RecruitingObservational study
Ages 2 to 25 · All sexes · Updated Jul 14, 2026 · NCT04181138

Veteran-Centered Care for Advanced Liver Disease (Vet-CALD)

Recruiting
Ages 18 to 80 · All sexes · Updated Jun 25, 2026 · NCT06068491

Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

Recruiting
Ages 18 and older · All sexes · Updated Jun 25, 2026 · NCT06138821

A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinoma

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jun 17, 2026 · NCT06600321

Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 4, 2026 · NCT03193151

Metabolic Responses to Bariatric Surgery

RecruitingObservational study
Ages 18 to 55 · All sexes · Updated May 18, 2026 · NCT02024542

Microbiome Modulation With Prebiotics in PTSD and Cirrhosis

Recruiting
Ages 18 and older · All sexes · Updated Apr 9, 2026 · NCT06464952

DILIN - Prospective Study

RecruitingObservational studyHealthy volunteers welcome
Ages 2 and older · All sexes · Updated Apr 8, 2026 · NCT00345930

Enhancing Alcohol Treatment Engagement in Associated Liver Disease (ALD) Patients

Recruiting
Ages 18 and older · All sexes · Updated Feb 3, 2026 · NCT06269510

MAsS Scan as a Predictor of Morbidity and Mortality in Patients With Liver Disease

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jan 14, 2026 · NCT05264051

A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD)

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Dec 15, 2025 · NCT06619561

The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 4, 2025 · NCT06871111

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.