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Liver Diseases clinical trials recruiting in the U.S.

33 studies for Liver Diseases are recruiting participants at sites across the United States.

Get the facts about liver diseases, such as hepatitis, cancer, and cirrhosis. Know your risk and what you can do to prevent liver problems.

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Recently updated studies

Long-Term SafEty and Clinical Outcomes of LivmArli in Patients in the United States (LEAP-US)

RecruitingObservational study
All ages · All sexes · Updated Nov 13, 2026 · NCT06193928

Veteran-Centered Care for Advanced Liver Disease (Vet-CALD)

Recruiting
Ages 18 to 80 · All sexes · Updated Nov 13, 2026 · NCT06068491

Evaluation of Patients With Liver Disease

RecruitingObservational studyHealthy volunteers welcome
Ages 2 to 100 · All sexes · Updated Nov 12, 2026 · NCT00001971

Natural History of Noncirrhotic Portal Hypertension

RecruitingObservational study
Ages 12 to 100 · All sexes · Updated Nov 9, 2026 · NCT02417740

A Trial of Post-Discharge Transitional Care for Patients With Chronic Liver Disease

Recruiting
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT05733832

Long-term Follow-up (LTFU) Study of Participants in Any iECURE Protocol Using an Investigational Product (IP)

RecruitingObservational study
7 Months – 15 Months · All sexes · Updated Nov 5, 2026 · NCT06805695

Study of AHB-137 in Chronic Hepatitis B (CHB) Participants in North America and Europe Regions

RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Oct 29, 2026 · NCT07654283

Unraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative Research Approach

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 90 · All sexes · Updated Oct 29, 2026 · NCT04685200

A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinoma

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT06600321

A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH

RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Oct 23, 2026 · NCT06419374

A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)

RecruitingPhase 3
Ages 18 to 80 · All sexes · Updated Oct 23, 2026 · NCT06318169

ENLIGHT Trial: ESG With Fundal Mucosal Ablation

Recruiting
Ages 18 and older · All sexes · Updated Oct 19, 2026 · NCT07792226

Blood Collection Biorepository for Liver Disease Research

RecruitingObservational studyHealthy volunteers welcome
Ages 7 and older · All sexes · Updated Oct 8, 2026 · NCT03025074

Safety and Efficacy of Atorvastatin v. Placebo on HCC Risk

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 7, 2026 · NCT05028829

Noninvasive Subharmonic Aided Pressure Estimation of Portal Hypertension; Renewal

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05470205

Observational Pharmaco-Epidemiology Research & Analysis

RecruitingObservational studyHealthy volunteers welcome
Ages 0 and older · All sexes · Updated Sep 11, 2026 · NCT03813862

Study of Resmetirom in Children and Adolescents With MASH

RecruitingPhase 2
Ages 6 to 17 · All sexes · Updated Sep 11, 2026 · NCT07763015

Development and Testing of a Patient-facing Educational Tool About Liver Cancer Prevention

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT07010315

Primary Sclerosing Cholangitis in Children

RecruitingObservational study
Ages 2 to 25 · All sexes · Updated Jul 14, 2026 · NCT04181138

Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

Recruiting
Ages 18 and older · All sexes · Updated Jun 25, 2026 · NCT06138821

Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 4, 2026 · NCT03193151

Metabolic Responses to Bariatric Surgery

RecruitingObservational study
Ages 18 to 55 · All sexes · Updated May 18, 2026 · NCT02024542

Microbiome Modulation With Prebiotics in PTSD and Cirrhosis

Recruiting
Ages 18 and older · All sexes · Updated Apr 9, 2026 · NCT06464952

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.