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Lymphatic Abnormalities clinical trials recruiting in the U.S.
7 studies for Lymphatic Abnormalities are recruiting participants at sites across the United States.
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Recently updated studies
A Prospective Natural History Study of Lymphatic Anomalies
RecruitingObservational studyHealthy volunteers welcome
1 Day – 100 Years · All sexes · Updated Sep 28, 2026 · NCT05731141A Study to Investigate Efficacy and Safety of KP-001 Compared With Placebo in Patients Aged ≥2 Years With Common VM, Common LM, or KTS/CLOVES Syndrome
RecruitingPhase 3
Ages 2 and older · All sexes · Updated Sep 21, 2026 · NCT07285005Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation.
RecruitingPhase 2/3
Ages 0 to 100 · All sexes · Updated Sep 18, 2026 · NCT05948943Lymphatic Anomalies Registry for the Assessment of Outcome Data
RecruitingObservational study
All ages · All sexes · Updated Sep 10, 2026 · NCT02399527A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)
RecruitingPhase 2
Ages 2 and older · All sexes · Updated Aug 25, 2026 · NCT06789913Safety and Efficacy Study of Intracystic TARA-002 for the Treatment of Lymphatic Malformations in Participants 6 Months to Less Than 18 Years of Age
RecruitingPhase 2
6 Months – 18 Years · All sexes · Updated Aug 24, 2026 · NCT05871970Weekly Sirolimus Therapy
RecruitingPhase 2
Ages 2 and older · All sexes · Updated Mar 5, 2026 · NCT04861064From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.