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Macular Degeneration clinical trials recruiting in the U.S.

55 studies for Macular Degeneration are recruiting participants at sites across the United States.

Macular degeneration, or age-related macular degeneration (AMD), causes vision loss in older adults. Learn about the types and what can help.

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Recently updated studies

National Eye Institute Biorepository for Retinal Diseases

RecruitingObservational studyHealthy volunteers welcome
Ages 2 to 120 · All sexes · Updated Sep 28, 2026 · NCT01496625

Cell Collection to Study Eye Diseases

RecruitingObservational studyHealthy volunteers welcome
1 Day – 120 Years · All sexes · Updated Sep 22, 2026 · NCT01432847

A Study in Adults With Geographic Atrophy

RecruitingPhase 2
Ages 60 and older · All sexes · Updated Sep 21, 2026 · NCT07606365

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)

RecruitingPhase 2/3
Ages 50 and older · All sexes · Updated Sep 18, 2026 · NCT07440225

The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT06319872

A Phase 2 Study of NT-101 Topical in Patients With Wet AMD

RecruitingPhase 2
Ages 50 and older · All sexes · Updated Sep 16, 2026 · NCT07811726

Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD

RecruitingPhase 2
Ages 55 and older · All sexes · Updated Sep 10, 2026 · NCT06659445

A Non-Interventional Study Observing Short-Term Progression in Geographic Atrophy (GA)

RecruitingObservational study
Ages 55 and older · All sexes · Updated Sep 3, 2026 · NCT07144137

Noninvasive Imaging Biomarkers of Treatable Macrovascular Disease in Age-related Macular Degeneration.

RecruitingObservational study
Ages 50 to 80 · All sexes · Updated Sep 3, 2026 · NCT07798323

A Long-term Follow-up Study to Evaluate SKG0106 in the Treatment of Patients With nAMD

RecruitingObservational study
Ages 50 and older · All sexes · Updated Sep 1, 2026 · NCT06346600

Effect of Lutein, Zeaxanthin, and Meso-Zeaxanthin Supplementation on Skin Carotenoid Concentration: A Six-Month, Placebo-Controlled Crossover Study

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT06965426

SGLT2 Inhibitors in Geographic Atrophy

RecruitingPhase 2
Ages 50 and older · All sexes · Updated Aug 26, 2026 · NCT07174687

Microcurrent Stimulation Therapy for Intermediate to Advanced Nonexudative Age-related Macular Degeneration

Recruiting
Ages 60 and older · All sexes · Updated Aug 26, 2026 · NCT06662162

A Study to Learn How Stargardt-type Eye Conditions Progress in Children and Adults

RecruitingObservational study
Ages 6 and older · All sexes · Updated Aug 25, 2026 · NCT07425574

4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration

RecruitingPhase 1/2
Ages 50 and older · All sexes · Updated Aug 21, 2026 · NCT05197270

Phase 1 Study of C.001 in Retinal Degeneration

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT07594236

AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance

RecruitingHealthy volunteers welcome
Ages 50 to 89 · All sexes · Updated Aug 10, 2026 · NCT06619405

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)

RecruitingPhase 2/3
Ages 50 and older · All sexes · Updated Aug 6, 2026 · NCT07496567

Intravitreal (IVT) Pozelimab for Geographic Atrophy (GA) in Adult Participants

RecruitingPhase 1
Ages 50 and older · All sexes · Updated Aug 5, 2026 · NCT07230834

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.