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Macular Degeneration clinical trials recruiting in the U.S.
56 studies for Macular Degeneration are recruiting participants at sites across the United States.
Macular degeneration, or age-related macular degeneration (AMD), is the leading cause of vision loss in older adults. Learn about the types and what might help.
Cities with the most studies
- Dallas, TX12 studies
- Erie, PA9 studies
- The Woodlands, TX9 studies
- Sacramento, CA7 studies
- Carmel, IN7 studies
- Santa Monica, CA7 studies
- Hagerstown, MD7 studies
- Houston, TX7 studies
- Phoenix, AZ7 studies
- McAllen, TX7 studies
- Cleveland, OH7 studies
- Reno, NV7 studies
- Boston, MA7 studies
- Washington, DC6 studies
- Raleigh, NC6 studies
- Austin, TX6 studies
- Philadelphia, PA6 studies
- Fort Worth, TX6 studies
- Naperville, IL6 studies
- Salt Lake City, UT6 studies
- Nashville, TN5 studies
- Durham, NC5 studies
- Columbia, SC5 studies
- San Antonio, TX5 studies
- Mountain View, CA5 studies
- Portland, OR5 studies
- Fort Lauderdale, FL5 studies
- Spokane, WA5 studies
- Cincinnati, OH5 studies
- Memphis, TN5 studies
- Sarasota, FL4 studies
- Cypress, TX4 studies
- Orlando, FL4 studies
- Pensacola, FL4 studies
- Syracuse, NY4 studies
- Tampa, FL4 studies
- St. Louis, MO4 studies
- Lynchburg, VA4 studies
- Ann Arbor, MI4 studies
- San Francisco, CA4 studies
By state
- Arizona10 studies
- California20 studies
- Colorado6 studies
- Connecticut7 studies
- Florida14 studies
- Georgia6 studies
- Illinois12 studies
- Indiana7 studies
- Maryland10 studies
- Massachusetts13 studies
- Michigan8 studies
- Minnesota5 studies
- Mississippi6 studies
- Missouri5 studies
- Nevada7 studies
- New Jersey6 studies
- New York9 studies
- North Carolina10 studies
- Ohio10 studies
- Oklahoma3 studies
- Oregon8 studies
- Pennsylvania16 studies
- South Carolina7 studies
- Tennessee6 studies
- Texas24 studies
- Utah8 studies
- Virginia6 studies
- Washington7 studies
- Wisconsin5 studies
Recently updated studies
A Study to Learn How Stargardt-type Eye Conditions Progress in Children and Adults
RecruitingObservational study
Ages 6 and older · All sexes · Updated Nov 13, 2026 · NCT07425574Cell Collection to Study Eye Diseases
RecruitingObservational studyHealthy volunteers welcome
1 Day – 120 Years · All sexes · Updated Nov 10, 2026 · NCT01432847A Phase 2 Efficacy and Safety Study of GAL-101, 2% Ophthalmic Solution in Non-foveal Geographic Atrophy Secondary to Non-neovascular AMD
RecruitingPhase 2
Ages 55 and older · All sexes · Updated Nov 10, 2026 · NCT06659549Pivotal Trial of an Automated AI-based System for Early Diagnosis and Prediction of Late Age-related Macular Degeneration
RecruitingObservational studyHealthy volunteers welcome
Ages 50 and older · All sexes · Updated Nov 6, 2026 · NCT07084883A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy
RecruitingPhase 3
Ages 50 to 85 · All sexes · Updated Nov 5, 2026 · NCT06541704Safety and Efficacy of AIV007 Periocular Injection in Patients With Neovascular Age-Related Macular Degeneration
RecruitingPhase 2
Ages 50 to 85 · All sexes · Updated Nov 4, 2026 · NCT07557121A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)
RecruitingPhase 2/3
Ages 60 and older · All sexes · Updated Nov 3, 2026 · NCT06635148Phase 1 Study of C.001 in Retinal Degeneration
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07594236Age-Related Macular Degeneration Benchmark Imaging Dataset (ABID)
RecruitingObservational studyHealthy volunteers welcome
Ages 50 and older · All sexes · Updated Oct 30, 2026 · NCT06924021A Study About the Safety of a Single ASP2020 Eye Injection and if it Helps People With Vision Loss From Stargardt-type Eye Conditions
RecruitingPhase 1
Ages 6 and older · All sexes · Updated Oct 28, 2026 · NCT07734064National Eye Institute Biorepository for Retinal Diseases
RecruitingObservational studyHealthy volunteers welcome
Ages 2 to 120 · All sexes · Updated Oct 26, 2026 · NCT01496625A Non-Interventional Study Observing Short-Term Progression in Geographic Atrophy (GA)
RecruitingObservational study
Ages 55 and older · All sexes · Updated Oct 16, 2026 · NCT07144137Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for NAION
RecruitingPhase 1
All ages · All sexes · Updated Oct 16, 2026 · NCT05147701Phase 1b/2a Study of EYC-0305 in Patients With Neovascular Age-related Macular Degeneration
RecruitingPhase 1/2
Ages 50 and older · All sexes · Updated Oct 9, 2026 · NCT07587515A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)
RecruitingPhase 2/3
Ages 50 and older · All sexes · Updated Oct 2, 2026 · NCT07440225A Phase 1/2 Study of the Safety and Efficacy of BRX011 Oral Administration Once Daily in Subjects With Geographic Atrophy Secondary to Age-Related Macular Degeneration
RecruitingPhase 1/2
Ages 55 and older · All sexes · Updated Sep 23, 2026 · NCT07029945A Study in Adults With Geographic Atrophy
RecruitingPhase 2
Ages 60 and older · All sexes · Updated Sep 21, 2026 · NCT07606365The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT06319872A Phase 2 Study of NT-101 Topical in Patients With Wet AMD
RecruitingPhase 2
Ages 50 and older · All sexes · Updated Sep 16, 2026 · NCT07811726Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD
RecruitingPhase 2
Ages 55 and older · All sexes · Updated Sep 10, 2026 · NCT06659445Noninvasive Imaging Biomarkers of Treatable Macrovascular Disease in Age-related Macular Degeneration.
RecruitingObservational study
Ages 50 to 80 · All sexes · Updated Sep 3, 2026 · NCT07798323A Study of the Safety and Tolerability of ASP7317 in Senior Adults Who Are Losing Their Clear, Sharp Central Vision Due to Geographic Atrophy Secondary to Dry Age-related Macular Degeneration
RecruitingPhase 1
Ages 50 and older · All sexes · Updated Sep 3, 2026 · NCT03178149Effect of Lutein, Zeaxanthin, and Meso-Zeaxanthin Supplementation on Skin Carotenoid Concentration: A Six-Month, Placebo-Controlled Crossover Study
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT06965426A Long-term Follow-up Study to Evaluate SKG0106 in the Treatment of Patients With nAMD
RecruitingObservational study
Ages 50 and older · All sexes · Updated Sep 1, 2026 · NCT06346600Microcurrent Stimulation Therapy for Intermediate to Advanced Nonexudative Age-related Macular Degeneration
Recruiting
Ages 60 and older · All sexes · Updated Aug 26, 2026 · NCT06662162From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.