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A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)

RecruitingPhase 2/3

A Randomized Double-masked, Multicenter, 3-arm, Pivotal Phase 2/3 Study to Evaluate the Efficacy and Safety of Intravitreal (IVT) EYE201/MK-8748 Compared to Aflibercept (2 mg) in Participants With Neovascular Age-related Macular Degeneration (NVAMD)

Who can join

Ages 50 and older · All sexes

Full eligibility criteria
The main inclusion criteria include but are not limited to the following:

* Has treatment naive choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) including subfoveal, juxtafoveal and extrafoveal lesions or retinal angiomatous proliferations (RAP) and polypoidal choroidal vascularization (PCV) lesions in at least one eye (study eye)
* The diagnosis of neovascular age-related macular degeneration (NVAMD) must have been made within 21 days prior to starting study treatment

The main exclusion criteria include but are not limited to the following

* Has uncontrolled blood pressure at screening
* History of any prior macular laser photocoagulation in the study eye
* History of uveitis in either eye
* History of cataract surgery, minimally invasive glaucoma surgery, or Yttrium-Aluminium Garnet (Yag) laser capsulotomy in the study eye within 90 days before entering the study
* Has uncontrolled glaucoma in the study eye
* Active retinal disease other than the condition under investigation in the study eye
* Has previously received anti- vascular endothelial growth factor (VEGF) therapy or other intravitreal (IVT) therapy in the study eye

About the study

Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD).

Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD.

The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.

What is being tested

Sponsor: EyeBiotech Ltd. · Participants: 960 · Started: Mar 27, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07440225

Locations in the U.S.

ArizonaResearch Network Arizona / Retina Macula Institute of Arizona, Scottsdale
ArkansasRetina Center of Arkansas, Fayetteville
Retina Partners of Northwest Arkansas, PLLC, Springdale
CaliforniaGlobal Research Management, Inc., Glendale
Retinal Consultants Medical Group (Site 024), Modesto
Azul Vision / California Eye Specialists Medical Group, Inc., Pasadena
Retina Consultants of Southern California (Site 043), Redlands
Retinal Consultants Medical Group (Site 020), Sacramento
Retinal Consultants Medical Group (Site 022), Sacramento
FloridaFlorida Eye Clinic (Site 130), Altamonte Springs
Retina Group of Florida (Site 070), Fort Lauderdale
Vitreo Retinal Associates, Gainesville
Florida Retina Institute, Jacksonville
Florida Retina Consultants, Lakeland
Retina Care Specialists, Palm Beach Gardens
Fort Lauderdale Eye Institute (Site 042), Plantation
Retina Vitreous Associates of Florida (Site 049), St. Petersburg
Southern Vitreoretinal Associates, Tallahassee
Retina Associates of Florida, LLC, Tampa
Retina Vitreous Associates of Florida, Tampa
Wildwood Clinical Research / Florida Retina Institute, Wildwood
IllinoisIllinois Retina Associates, Oak Park
Springfield Clinic, Springfield
IndianaAssociated Vitreoretinal and Uveitis Consultants, Carmel
Midwest Eye Institute, Carmel
MarylandCumberland Valley Retina Consultants (Site 007), Hagerstown
MichiganFoundation for Vision Research (Site 073), Grand Rapids
MinnesotaRetina Consultants of Minnesota, Saint Louis Park
MississippiRetina Specialists of Mississippi, Hattiesburg
Mississippi Retina Associates (Site 084), Madison
New JerseyMid Atlantic Retina, Cherry Hill
New MexicoVision Research Center Eye Associates of New Mexico, Albuquerque
New Yorkong Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY (Site 105), Hauppauge
Retina Vitreous Surgeons of CNY, PC (Site 033), Liverpool
North CarolinaPiedmont Retina Specialists - Greensboro, Greensboro
North Carolina Retina Associates, Greenville
Piedmont Retina Specialists - Winston-Salem, Winston-Salem
OhioCincinnati Eye Institute (Site 133), Cincinnati
OklahomaRetina Vitreous Center, Edmond
Tulsa Retina Consultants, Tulsa
OregonEyeHealth Northwest, Portland
Retina Northwest, PC, Portland
PennsylvaniaMid Atlantic Retina (Site 050), Bethlehem
South CarolinaPalmetto Retina Center, Aiken
Charleston Neuroscience Institute - Bluffton (Site 124), Bluffton
Charleston Neuroscience Institute (Site 104), Charleston
Charleston Neuroscience Institute (CNI) d/b/a Retina Consultants of South Carolina, Mt. Pleasant
TennesseeCharles Retina Institute, Germantown
TexasRetina Research Institute of Texas (Site 010), Abilene
Southwest Retina Specialists, Amarillo
Texas Retina Associates, Arlington
Austin Research Center for Retina, Austin
Austin Retina Associates (Site 012), Austin
Retina & Vitreous of Texas, Bellaire
Texas Retina Associates, Dallas
Texas Retina (Site 037), Plano
Retina Center of Texas, Southlake
Retina Consultants of Texas (Site 014), The Woodlands
Tyler Retina Research Institute, Tyler
Strategic Clinical Research Group, Weatherford
UtahRetina Associates of Utah, Salt Lake City
VirginiaPiedmont Eye Center (Site 054), Lynchburg
WashingtonPacific Northwest Retina (Site 112), Burlington
Spokane Eye Clinical Research (Site 075), Spokane
West VirginiaRetina Consultants, PLLC, Charleston
WisconsinEye Clinic of Wisconsin, Wausau

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.