Home › Macular Degeneration › NCT07440225
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)
RecruitingPhase 2/3
A Randomized Double-masked, Multicenter, 3-arm, Pivotal Phase 2/3 Study to Evaluate the Efficacy and Safety of Intravitreal (IVT) EYE201/MK-8748 Compared to Aflibercept (2 mg) in Participants With Neovascular Age-related Macular Degeneration (NVAMD)
Who can join
Ages 50 and older · All sexes
Full eligibility criteria
The main inclusion criteria include but are not limited to the following:
* Has treatment naive choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) including subfoveal, juxtafoveal and extrafoveal lesions or retinal angiomatous proliferations (RAP) and polypoidal choroidal vascularization (PCV) lesions in at least one eye (study eye)
* The diagnosis of neovascular age-related macular degeneration (NVAMD) must have been made within 21 days prior to starting study treatment
The main exclusion criteria include but are not limited to the following
* Has uncontrolled blood pressure at screening
* History of any prior macular laser photocoagulation in the study eye
* History of uveitis in either eye
* History of cataract surgery, minimally invasive glaucoma surgery, or Yttrium-Aluminium Garnet (Yag) laser capsulotomy in the study eye within 90 days before entering the study
* Has uncontrolled glaucoma in the study eye
* Active retinal disease other than the condition under investigation in the study eye
* Has previously received anti- vascular endothelial growth factor (VEGF) therapy or other intravitreal (IVT) therapy in the study eye
About the study
Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD).
Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD.
The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.
What is being tested
- Tiespectus (drug)
- Aflibercept (drug)
Sponsor: EyeBiotech Ltd. · Participants: 960 · Started: Mar 27, 2026
Contact the study team
Official record on ClinicalTrials.gov — NCT07440225
Locations in the U.S.
| Arizona | Research Network Arizona / Retina Macula Institute of Arizona, Scottsdale |
| Arkansas | Retina Center of Arkansas, Fayetteville Retina Partners of Northwest Arkansas, PLLC, Springdale |
| California | Global Research Management, Inc., Glendale Retinal Consultants Medical Group (Site 024), Modesto Azul Vision / California Eye Specialists Medical Group, Inc., Pasadena Retina Consultants of Southern California (Site 043), Redlands Retinal Consultants Medical Group (Site 020), Sacramento Retinal Consultants Medical Group (Site 022), Sacramento |
| Florida | Florida Eye Clinic (Site 130), Altamonte Springs Retina Group of Florida (Site 070), Fort Lauderdale Vitreo Retinal Associates, Gainesville Florida Retina Institute, Jacksonville Florida Retina Consultants, Lakeland Retina Care Specialists, Palm Beach Gardens Fort Lauderdale Eye Institute (Site 042), Plantation Retina Vitreous Associates of Florida (Site 049), St. Petersburg Southern Vitreoretinal Associates, Tallahassee Retina Associates of Florida, LLC, Tampa Retina Vitreous Associates of Florida, Tampa Wildwood Clinical Research / Florida Retina Institute, Wildwood |
| Illinois | Illinois Retina Associates, Oak Park Springfield Clinic, Springfield |
| Indiana | Associated Vitreoretinal and Uveitis Consultants, Carmel Midwest Eye Institute, Carmel |
| Maryland | Cumberland Valley Retina Consultants (Site 007), Hagerstown |
| Michigan | Foundation for Vision Research (Site 073), Grand Rapids |
| Minnesota | Retina Consultants of Minnesota, Saint Louis Park |
| Mississippi | Retina Specialists of Mississippi, Hattiesburg Mississippi Retina Associates (Site 084), Madison |
| New Jersey | Mid Atlantic Retina, Cherry Hill |
| New Mexico | Vision Research Center Eye Associates of New Mexico, Albuquerque |
| New York | ong Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY (Site 105), Hauppauge Retina Vitreous Surgeons of CNY, PC (Site 033), Liverpool |
| North Carolina | Piedmont Retina Specialists - Greensboro, Greensboro North Carolina Retina Associates, Greenville Piedmont Retina Specialists - Winston-Salem, Winston-Salem |
| Ohio | Cincinnati Eye Institute (Site 133), Cincinnati |
| Oklahoma | Retina Vitreous Center, Edmond Tulsa Retina Consultants, Tulsa |
| Oregon | EyeHealth Northwest, Portland Retina Northwest, PC, Portland |
| Pennsylvania | Mid Atlantic Retina (Site 050), Bethlehem |
| South Carolina | Palmetto Retina Center, Aiken Charleston Neuroscience Institute - Bluffton (Site 124), Bluffton Charleston Neuroscience Institute (Site 104), Charleston Charleston Neuroscience Institute (CNI) d/b/a Retina Consultants of South Carolina, Mt. Pleasant |
| Tennessee | Charles Retina Institute, Germantown |
| Texas | Retina Research Institute of Texas (Site 010), Abilene Southwest Retina Specialists, Amarillo Texas Retina Associates, Arlington Austin Research Center for Retina, Austin Austin Retina Associates (Site 012), Austin Retina & Vitreous of Texas, Bellaire Texas Retina Associates, Dallas Texas Retina (Site 037), Plano Retina Center of Texas, Southlake Retina Consultants of Texas (Site 014), The Woodlands Tyler Retina Research Institute, Tyler Strategic Clinical Research Group, Weatherford |
| Utah | Retina Associates of Utah, Salt Lake City |
| Virginia | Piedmont Eye Center (Site 054), Lynchburg |
| Washington | Pacific Northwest Retina (Site 112), Burlington Spokane Eye Clinical Research (Site 075), Spokane |
| West Virginia | Retina Consultants, PLLC, Charleston |
| Wisconsin | Eye Clinic of Wisconsin, Wausau |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.