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Major Depressive Disorder clinical trials in Massachusetts
44 studies for Major Depressive Disorder are looking for participants at sites in Massachusetts.
Cities in Massachusetts
Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
- Adams Clinical LLC, Watertown
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Sep 25, 2026 · NCT06559306A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
- Activmed Practices & Research, Llc - Methuen, Methuen
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07621237A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder
- Boston Childrens Hospital, Boston
RecruitingPhase 3
Ages 12 to 17 · All sexes · Updated Sep 25, 2026 · NCT07227454A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
- Adams Clinical Boston, Boston
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Sep 25, 2026 · NCT06793397Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder
- Vanda Investigational Site, Boston
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 24, 2026 · NCT06830044The Medically Tailored Groceries and Mental Health Study
- UMass Chan Medical School, Worcester
- Community Care Cooperative (C3), Worcester
- UMass Memorial Health, Worcester
Recruiting
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07779707Accelerated TMS for Perinatal Depression
- Brigham and Women's Hospital, Boston
Recruiting
Ages 18 to 55 · Women · Updated Sep 18, 2026 · NCT06968390A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
- Seaport Investigator Site, Boston
- Seaport Investigator Site, Russells Mills
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT07065240ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
- Adams Clinical, Inc., Watertown
- Vitalix Clinical, Inc., Worcester
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT07284667A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)
- Adams Clinical Boston, Boston
- Activmed Practices & Research, Llc - Methuen, Methuen
- Adams Clinical Watertown, Watertown
- and 1 more
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Sep 8, 2026 · NCT07076407A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
- Draig Clinical Site, Boston
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 2, 2026 · NCT07610473Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
- Massachusetts General Hospital, Boston
- Beth Israel Deaconess Medical Center, Boston
Recruiting
Ages 22 to 70 · All sexes · Updated Aug 28, 2026 · NCT06423430A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
- Adams Clinical Boston, Boston
- Adams Clinical Watertown, Watertown
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Aug 28, 2026 · NCT07573176A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
- Draig Clinical Site, Watertown
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Aug 26, 2026 · NCT07300969Home-Based tDCS Treatment Of Major Depressive Disorder
- Curavit Clinical Research (virtual study site), Boston
Recruiting
Ages 22 to 70 · All sexes · Updated Aug 14, 2026 · NCT06976697The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disorder
- Athinoula A. Martinos Center for Biomedical Imaging, Charlestown
RecruitingPhase 3
Ages 18 to 55 · All sexes · Updated Aug 13, 2026 · NCT06247839A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
- Adams Clinical Boston, Boston
- Adams Clinical Watertown, Boston
- Vitalix Clinical, Worcester
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Aug 10, 2026 · NCT07592689A Study of Brenipatide in Adult Participants With Major Depressive Disorder
- Adams Clinical Boston, Boston
- K2 Medical Research - Foxborough, Foxborough
- Adams Clinical Watertown, Watertown
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Aug 6, 2026 · NCT07412756A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder
- Boston Clinical Trials Llc, Boston
- ELIXIA, Springfield
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Aug 3, 2026 · NCT06775379Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
- Mayflower Clinical, Russells Mills
RecruitingPhase 2
Ages 18 to 64 · All sexes · Updated Aug 3, 2026 · NCT06547489A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
- Vitalix Clinical, Worcester
RecruitingPhase 2
Ages 18 to 64 · All sexes · Updated Jul 27, 2026 · NCT07115329Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Boston
- Neurocrine Clinical Site, Watertown
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
- Clinical Research Site, Springfield
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Jul 24, 2026 · NCT07484217Triage Survey for Psychiatry Research Eligibility
- Adams Clinical, Boston, Boston
- Adams Clinical, Watertown, Watertown
RecruitingObservational study
Ages 18 and older · All sexes · Updated May 20, 2026 · NCT05800925Neural Correlates of Stress and Perceived Control in Adolescent Depression
- McLean Hospital, Belmont
RecruitingHealthy volunteers welcome
Ages 14 to 18 · Women · Updated May 19, 2026 · NCT04788524Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological Manipulation
- Mclean Hospital, Belmont
RecruitingPhase 2Healthy volunteers welcome
Ages 18 to 45 · All sexes · Updated May 18, 2026 · NCT05232032Mechanisms Of Orbitofrontal Stimulation in Depression
- Beth Israel Deaconess Medical Center, Boston
Recruiting
Ages 18 to 65 · All sexes · Updated May 14, 2026 · NCT07230990Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression
- McLean Hospital, Belmont
RecruitingEarly phase 1
Ages 18 and older · All sexes · Updated May 13, 2026 · NCT07560878A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
- Elixia MA, Springfield
- Adams Clinical, Watertown
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated May 11, 2026 · NCT06524830Mindfulness-Based fMRI Neurofeedback for Depression
- Northeastern University, Boston
Recruiting
Ages 13 to 18 · All sexes · Updated Apr 29, 2026 · NCT05617495REVEAL Study - Diagnostic Testing for PTSD Using the Senseye Diagnostic Tool
- Lindus Health (Virtual Study Site), Boston
RecruitingPhase 3Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Apr 29, 2026 · NCT07280065Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services
- McLean Hospital, Belmont
- Beth Israel Deaconess Medical Center, Boston
RecruitingObservational study
Ages 18 to 40 · All sexes · Updated Mar 10, 2026 · NCT06740383Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33
- Harvard Medical School, Boston
Recruiting
Ages 18 to 65 · All sexes · Updated Feb 5, 2026 · NCT05573074Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)
- Autobahn Site #137, Boston
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Jan 20, 2026 · NCT06633016Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression
- Massachusetts General Hospital, Boston
RecruitingPhase 4
Ages 18 to 70 · All sexes · Updated Dec 12, 2025 · NCT05450432Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
- Neurocrine Clinical Site, Boston
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 29, 2025 · NCT06786624Stress Dynamics and Familial Risk for Depression in Female Adolescents
- McLean Hospital, Belmont
RecruitingHealthy volunteers welcome
Ages 13 to 15 · Women · Updated Oct 23, 2025 · NCT06816329Beyond Monoamines: The Role of the Nociceptin/Orphanin FQ Receptor in Major Depression
- McLean Hospital, Belmont
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 45 · All sexes · Updated Oct 21, 2025 · NCT05630963Targeting Specific Brain Networks to Treat Specific Symptoms in Depression
- Massachusetts General Hospital, Boston
RecruitingHealthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Sep 29, 2025 · NCT05523817Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV
- Massachusetts General Hospital, Boston
RecruitingPhase 2
Ages 18 to 85 · All sexes · Updated Sep 12, 2025 · NCT05570812From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.