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Major Depressive Disorder clinical trials recruiting in the U.S.
160 studies for Major Depressive Disorder are recruiting participants at sites across the United States.
Cities with the most studies
- New York City, NY34 studies
- Boston, MA31 studies
- Atlanta, GA24 studies
- Houston, TX21 studies
- Philadelphia, PA20 studies
- Orlando, FL18 studies
- Miami, FL17 studies
- Tampa, FL17 studies
- Chicago, IL15 studies
- San Diego, CA14 studies
- Orange, CA13 studies
- Las Vegas, NV13 studies
- Austin, TX13 studies
- Jacksonville, FL12 studies
- Little Rock, AR11 studies
- Cincinnati, OH11 studies
- Concord, CA11 studies
- Washington, DC11 studies
- Birmingham, AL10 studies
- Newton, MA10 studies
- Los Angeles, CA10 studies
- Grand Prairie, TX10 studies
- Glendale, CA9 studies
- Dallas, TX9 studies
- Bellevue, WA9 studies
- San Bernardino, CA8 studies
- Brooklyn, NY8 studies
- Hartford, CT8 studies
- San Jose, CA8 studies
- Oceanside, CA8 studies
- Chino, CA8 studies
- O'Fallon, MO8 studies
- Phoenix, AZ8 studies
- Cambridge, MA8 studies
- Everett, WA7 studies
- Columbus, OH7 studies
- New Haven, CT7 studies
- Hollywood, FL7 studies
- Cleveland, OH7 studies
- St. Louis, MO7 studies
By state
- Alabama15 studies
- Arizona12 studies
- Arkansas13 studies
- California49 studies
- Colorado9 studies
- Connecticut15 studies
- District of Columbia3 studies
- Florida33 studies
- Georgia31 studies
- Illinois18 studies
- Indiana4 studies
- Iowa5 studies
- Louisiana4 studies
- Maryland19 studies
- Massachusetts48 studies
- Michigan4 studies
- Minnesota8 studies
- Mississippi4 studies
- Missouri15 studies
- Nebraska3 studies
- Nevada13 studies
- New Jersey9 studies
- New York42 studies
- North Carolina13 studies
- Ohio25 studies
- Oklahoma10 studies
- Oregon6 studies
- Pennsylvania24 studies
- South Carolina8 studies
- Tennessee5 studies
- Texas38 studies
- Utah14 studies
- Virginia7 studies
- Washington19 studies
- Wisconsin3 studies
Recently updated studies
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Nov 13, 2026 · NCT06793397Precision Depression Adalimumab Trial
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07845604Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders
RecruitingPhase 2Healthy volunteers welcome
Ages 8 to 65 · All sexes · Updated Nov 12, 2026 · NCT00018057Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
RecruitingPhase 1
Ages 18 to 70 · All sexes · Updated Nov 12, 2026 · NCT03973268Longitudinal Assessment of Biomarkers Among Patients With MDD
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07931001Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression
RecruitingPhase 4
Ages 18 to 70 · All sexes · Updated Nov 10, 2026 · NCT05450432The Role of mGluR5 in CBT-I
RecruitingPhase 4
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07076342A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Nov 10, 2026 · NCT07065240Natural History of Depression, Bipolar Disorder and Suicide Risk
RecruitingObservational study
Ages 18 to 120 · All sexes · Updated Nov 9, 2026 · NCT06462196Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Nov 9, 2026 · NCT03065335Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium
Recruiting
Ages 22 to 85 · All sexes · Updated Nov 9, 2026 · NCT07594483A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Nov 9, 2026 · NCT07592689Neuromodulation of Motivation and Reward Oscillations
RecruitingHealthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Nov 9, 2026 · NCT07924852Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics
Recruiting
Ages 60 and older · All sexes · Updated Nov 6, 2026 · NCT05877885Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder
RecruitingPhase 2
Ages 21 to 80 · All sexes · Updated Nov 6, 2026 · NCT06592833ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Nov 5, 2026 · NCT07284667Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depression
RecruitingPhase 2
Ages 18 to 90 · All sexes · Updated Nov 4, 2026 · NCT06559826A Study of Brenipatide in Adult Participants With Major Depressive Disorder
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Nov 4, 2026 · NCT07412756Peer-Delivered Behavioral Activation in a CCBHC
Recruiting
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07219394Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Nov 3, 2026 · NCT06559306Defining Neurobiological Links Between Substance Use and Mental Illness
RecruitingHealthy volunteers welcome
Ages 18 to 60 · All sexes · Updated Nov 3, 2026 · NCT05538910A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder
RecruitingPhase 3
Ages 12 to 17 · All sexes · Updated Nov 3, 2026 · NCT07227454A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Nov 3, 2026 · NCT07775300EEG-Guided Transcranial Magnetic Stimulation for Adults With Depression
Recruiting
Ages 22 to 60 · All sexes · Updated Nov 3, 2026 · NCT07862205Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Nov 3, 2026 · NCT05850689From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.