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Melanoma clinical trials in Kentucky

20 studies for Melanoma are looking for participants at sites in Kentucky.

Cities in Kentucky

Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)

  • Norton Cancer Institute, Louisville
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT04198766

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

  • CommonSpirit Saint Joseph Hospital - Bardstown, Bardstown
  • Commonwealth Cancer Center-Corbin, Corbin
  • Saint Elizabeth Healthcare Edgewood, Edgewood
  • and 5 more
RecruitingObservational studyHealthy volunteers welcome
Ages 40 to 75 · All sexes · Updated Nov 4, 2026 · NCT05334069

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

  • Flaget Memorial Hospital, Bardstown
  • Saint Joseph Hospital East, Lexington
  • Saint Joseph London, London
  • and 2 more
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06418204

Safety and Efficacy of OBX-115 in Advanced Solid Tumors

  • James Graham Brown Cancer Center (Melanoma/NSCLC), Louisville
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT06060613

A Study of BI 3810944 in Patients With Advanced Cancer

  • University of Louisville, Louisville
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT07224425

A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors

  • Research Site 115, Louisville
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 21, 2026 · NCT05914116

Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer

  • University of Kentucky/Markey Cancer Center, Lexington
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 14, 2026 · NCT05896839

MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma

  • University of Kentucky, Lexington
RecruitingPhase 1/2
Ages 18 to 90 · All sexes · Updated Oct 13, 2026 · NCT05655312

Pan-tumor MRD Study

  • Baptist Health Corbin, Corbin
  • Baptist Health Hardin, Elizabethtown
  • Baptist Health Lexington, Lexington
  • and 1 more
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06605404

Comparing the Effectiveness of Less Invasive Procedures With the Current Standard of Care for the Treatment of Older Adults With Early-Stage Melanoma

  • CommonSpirit Saint Joseph Hospital - Bardstown, Bardstown
  • Commonwealth Cancer Center-Corbin, Corbin
  • CommonSpirit Saint Joseph Hospital - Lexington, Lexington
  • and 5 more
RecruitingPhase 3
Ages 75 and older · All sexes · Updated Sep 24, 2026 · NCT07068074

A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

  • Mercy Health - Paducah Medical Oncology and Hematology, Paducah
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT04511013

Project: Every Child for Younger Patients With Cancer

  • University of Kentucky/Markey Cancer Center, Lexington
  • Norton Children's Hospital, Louisville
RecruitingObservational study
Up to age 25 · All sexes · Updated Aug 25, 2026 · NCT02402244

A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer

  • University of Louisville, Louisville
RecruitingPhase 1/2
Ages 18 to 70 · All sexes · Updated Jun 11, 2026 · NCT05361174

Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)

  • St Elizabeth Healthcare (St Elizabeth Medical Center), Edgewood
  • St Elizabeth Healthcare (St Elizabeth Medical, Edgewood
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Feb 25, 2026 · NCT05549297

Nilotinib Plus Dabrafenib/Trametinib or Encorafenib/Binimetinib in Metastatic Melanoma

  • Markey Cancer Center, Lexington
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT04903119

Beta Glucan's Effect on Pembrolizumab Immunologic Response in Stage III-IV Melanoma

  • University of Louisville, Louisville
Recruiting
Ages 18 and older · All sexes · Updated Oct 30, 2025 · NCT04513028

Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

  • University of Kentucky, Lexington
Recruiting
Ages 18 and older · All sexes · Updated Nov 27, 2024 · NCT03860883

Neoadjuvant Combination Immunotherapy for Stage III Melanoma

  • University of Louisville, Louisville
RecruitingPhase 2
Ages 18 and older · All sexes · Updated May 2, 2024 · NCT03842943

The Gut Microbiome and Immune Checkpoint Inhibitor Therapy in Solid Tumors

  • Baptist Health Clinical Research, Elizabethtown
RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 27, 2022 · NCT05037825

A Phase I/II Trial of Vemurafenib and Metformin to Melanoma Patients

  • James Graham Brown Cancer Center-University of Louisville, Louisville
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 29, 2021 · NCT01638676

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.