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Melanoma clinical trials recruiting in the U.S.

196 studies for Melanoma are recruiting participants at sites across the United States.

Melanoma is the most serious type of skin cancer. Most have a black or black-blue area. Learn the 'ABCDE' of what to watch for and treatment options.

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Recently updated studies

Phase 1 Study of PF-08046033 in Advanced Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07519655

Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Melanoma

RecruitingObservational studyHealthy volunteers welcome
4 Weeks – 99 Years · All sexes · Updated Sep 28, 2026 · NCT00040352

A Clinical Study of Intismeran Autogene (V940) and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06961006

DESTINY-PANTUMOUR04

RecruitingObservational study
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06172478

Pan-tumor MRD Study

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06605404

A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children Using Pathology and Genetic Information

RecruitingPhase 2
Up to age 25 · All sexes · Updated Sep 24, 2026 · NCT07621614

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06047379

Intratumoral N17350 in Advanced Solid Tumors

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07339176

A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

RecruitingPhase 1
Ages 18 to 120 · All sexes · Updated Sep 22, 2026 · NCT06066138

Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors

RecruitingPhase 1/2
Ages 18 to 99 · All sexes · Updated Sep 22, 2026 · NCT06814496

Personalized Cancer Vaccine (PCV) Strategy in Patients With Solid Tumors and Molecular Residual Disease

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT06529822

A Pilot Study of ctDNA-Guided Immune Checkpoint Inhibitor Duration in Patients With Advanced Melanoma.

Recruiting
Ages 18 to 90 · All sexes · Updated Sep 21, 2026 · NCT07830225

Fecal Microbiota Transplantation in Treating Immune-Checkpoint Inhibitor Induced-Diarrhea or Colitis in Genitourinary Cancer Patients

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT04038619

BI-1808 as a Single Agent and With Pembrolizumab (KEYTRUDA® ) in Treatment of Advanced Malignancies(Keynote-D20)

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT04752826

Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma

RecruitingPhase 2
Ages 18 to 120 · All sexes · Updated Sep 16, 2026 · NCT05155033

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.