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Melanoma clinical trials recruiting in the U.S.

196 studies for Melanoma are recruiting participants at sites across the United States.

Melanoma is the most serious type of skin cancer. Most have a black or black-blue area. Learn the 'ABCDE' of what to watch for and treatment options.

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Recently updated studies

A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)

RecruitingPhase 1/2
6 Months – 17 Years · All sexes · Updated Nov 13, 2026 · NCT02332668

High Dose-Rate Brachytherapy for the Treatment of Both Primary and Secondary Unresectable Liver Malignancies

Recruiting
Ages 19 and older · All sexes · Updated Nov 12, 2026 · NCT05053555

Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma

RecruitingPhase 2
Ages 18 to 120 · All sexes · Updated Nov 12, 2026 · NCT05155033

Testing of an Educational Tool for Patients With Melanoma and Pre-Existing Autoimmune Disease Who Are Candidates for Immune Checkpoint Inhibitors

RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT04751396

Evaluation for NCI Surgery Branch Clinical Research Protocols

RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT00001823

BostonGene and Exigent Genomic INsight Study

RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06272864

A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06270706

Symptoms of Immune Checkpoint Inhibitor Therapy in Cutaneous Melanoma

RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07148245

Adjuvant/Neoadjuvant Immunotherapy in Melanoma Based on Serial Plasma ctDNA Monitoring

RecruitingPhase 2Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07930182

Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases

RecruitingPhase 1
Ages 12 to 50 · All sexes · Updated Nov 10, 2026 · NCT03093909

A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

RecruitingPhase 1
Ages 18 to 120 · All sexes · Updated Nov 10, 2026 · NCT06066138

IL-17 Blockade to Decrease irAEs (REPLAY)

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT07237594

A Feasibility Study Utilizing Immune Recall to Increase Response to Checkpoint Therapy

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT05077137

Phase 1 Study of PF-08046033 in Advanced Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07519655

A Phase 1 of CTX-8371 in Patients With Advanced Malignancies

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06150664

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
Ages 40 to 75 · All sexes · Updated Nov 4, 2026 · NCT05334069

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06418204

SI-B036-ST-101 in Advanced/Metastatic Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07857616

Safety and Efficacy of OBX-115 in Advanced Solid Tumors

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT06060613

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.