Home › Melanoma
Melanoma clinical trials recruiting in the U.S.
196 studies for Melanoma are recruiting participants at sites across the United States.
Melanoma is the most serious type of skin cancer. Most have a black or black-blue area. Learn the 'ABCDE' of what to watch for and treatment options.
Cities with the most studies
- Houston, TX61 studies
- New York City, NY41 studies
- Nashville, TN34 studies
- Los Angeles, CA34 studies
- Pittsburgh, PA31 studies
- Boston, MA25 studies
- St. Louis, MO23 studies
- Durham, NC22 studies
- Philadelphia, PA22 studies
- Tampa, FL21 studies
- Columbus, OH21 studies
- Dallas, TX21 studies
- San Francisco, CA21 studies
- Denver, CO19 studies
- Atlanta, GA19 studies
- Arlington, VA19 studies
- Salt Lake City, UT19 studies
- Aurora, CO18 studies
- Washington, DC18 studies
- Queens, NY17 studies
- San Diego, CA17 studies
- Orlando, FL17 studies
- Edison, NJ17 studies
- Grand Rapids, MI17 studies
- Jacksonville, FL16 studies
- Seattle, WA16 studies
- San Antonio, TX16 studies
- Rochester, MN16 studies
- Cincinnati, OH16 studies
- Madison, WI15 studies
- Portland, OR15 studies
- Chicago, IL15 studies
- Cleveland, OH14 studies
- Orange, CA14 studies
- New Haven, CT12 studies
- Minneapolis, MN12 studies
- Ann Arbor, MI12 studies
- Birmingham, AL12 studies
- Mountain View, CA12 studies
- Omaha, NE12 studies
By state
- Alabama13 studies
- Alaska5 studies
- Arizona26 studies
- Arkansas11 studies
- California69 studies
- Colorado33 studies
- Connecticut15 studies
- Delaware6 studies
- District of Columbia8 studies
- Florida56 studies
- Georgia21 studies
- Hawaii3 studies
- Idaho8 studies
- Illinois22 studies
- Indiana13 studies
- Iowa13 studies
- Kansas15 studies
- Kentucky20 studies
- Louisiana8 studies
- Maine4 studies
- Maryland24 studies
- Massachusetts28 studies
- Michigan30 studies
- Minnesota29 studies
- Mississippi3 studies
- Missouri25 studies
- Montana8 studies
- Nebraska16 studies
- Nevada6 studies
- New Hampshire6 studies
- New Jersey25 studies
- New Mexico11 studies
- New York52 studies
- North Carolina32 studies
- North Dakota9 studies
- Ohio41 studies
- Oklahoma15 studies
- Oregon15 studies
- Pennsylvania47 studies
- Rhode Island5 studies
- South Carolina10 studies
- South Dakota7 studies
- Tennessee42 studies
- Texas79 studies
- Utah23 studies
- Vermont5 studies
- Virginia33 studies
- Washington25 studies
- West Virginia7 studies
- Wisconsin21 studies
- Wyoming3 studies
Recently updated studies
A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)
RecruitingPhase 1/2
6 Months – 17 Years · All sexes · Updated Nov 13, 2026 · NCT02332668High Dose-Rate Brachytherapy for the Treatment of Both Primary and Secondary Unresectable Liver Malignancies
Recruiting
Ages 19 and older · All sexes · Updated Nov 12, 2026 · NCT05053555Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma
RecruitingPhase 2
Ages 18 to 120 · All sexes · Updated Nov 12, 2026 · NCT05155033Testing of an Educational Tool for Patients With Melanoma and Pre-Existing Autoimmune Disease Who Are Candidates for Immune Checkpoint Inhibitors
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT04751396BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT05136196Evaluation for NCI Surgery Branch Clinical Research Protocols
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT00001823BostonGene and Exigent Genomic INsight Study
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06272864A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06270706Symptoms of Immune Checkpoint Inhibitor Therapy in Cutaneous Melanoma
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07148245Adjuvant/Neoadjuvant Immunotherapy in Melanoma Based on Serial Plasma ctDNA Monitoring
RecruitingPhase 2Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07930182Lymphovenous Bypass Procedure Before Underarm Lymph Node Surgery in Preventing Lymphedema in Patients With Inflammatory or Locally Advanced Non-inflammatory Breast Cancer or Melanoma
Recruiting
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT03941756Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases
RecruitingPhase 1
Ages 12 to 50 · All sexes · Updated Nov 10, 2026 · NCT03093909A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing
RecruitingPhase 1
Ages 18 to 120 · All sexes · Updated Nov 10, 2026 · NCT06066138IL-17 Blockade to Decrease irAEs (REPLAY)
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT07237594A Feasibility Study Utilizing Immune Recall to Increase Response to Checkpoint Therapy
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT05077137A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT06246916Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT04198766Phase 1 Study of PF-08046033 in Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07519655A Phase 1 of CTX-8371 in Patients With Advanced Malignancies
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06150664Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
RecruitingObservational studyHealthy volunteers welcome
Ages 40 to 75 · All sexes · Updated Nov 4, 2026 · NCT05334069Positron Emission Tomography (PET) Guided Stereotactic Body Radiation Therapy for the Treatment of Oligoprogressive Non-small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT05830058Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06418204SI-B036-ST-101 in Advanced/Metastatic Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07857616A Study of Navlimetostat (BMS-986504) Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07492680Safety and Efficacy of OBX-115 in Advanced Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT06060613From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.