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Mood Disorders clinical trials recruiting in the U.S.

32 studies for Mood Disorders are recruiting participants at sites across the United States.

Most people feel sad or irritable sometimes. They may say they're in a bad mood. But mood disorders affect your everyday emotional state. Learn more.

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Recently updated studies

Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

RecruitingObservational studyHealthy volunteers welcome
Ages 3 to 99 · All sexes · Updated Sep 28, 2026 · NCT00024635

Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Sep 28, 2026 · NCT00397111

Characterization and Treatment of Adolescent Depression

RecruitingObservational studyHealthy volunteers welcome
Ages 11 to 25 · All sexes · Updated Sep 28, 2026 · NCT03388606

Studies of Brain Function and Course of Illness in Pediatric Bipolar Disorder

RecruitingObservational study
Ages 7 to 85 · All sexes · Updated Sep 23, 2026 · NCT00025935

Anxiety Skills Study

Recruiting
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT07774481

Digital Mental Health for Asian Americans

RecruitingHealthy volunteers welcome
Ages 18 to 90 · All sexes · Updated Aug 18, 2026 · NCT07771322

NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder

RecruitingObservational studyHealthy volunteers welcome
Ages 8 to 70 · All sexes · Updated Aug 13, 2026 · NCT05669703

A Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents

Recruiting
Ages 13 to 24 · All sexes · Updated Aug 12, 2026 · NCT07348666

A Study of Brenipatide in Adult Participants With Major Depressive Disorder

RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Aug 6, 2026 · NCT07412756

Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness

RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Jul 16, 2026 · NCT06376734

The Impact of Enhanced Music & Natural Visuals on Emotional Health

RecruitingHealthy volunteers welcome
Ages 13 and older · All sexes · Updated Jun 30, 2026 · NCT07676110

Phase II: Engagement and Clinical Impact of the Teleo Virtual Therapy Platform in Clinical Settings

Recruiting
Ages 5 to 14 · All sexes · Updated Jun 29, 2026 · NCT07155707

CARED : A Novel Rapid Treatment Paradigm for Depression

Recruiting
Ages 18 to 70 · All sexes · Updated Jun 25, 2026 · NCT07507370

RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty

Recruiting
Ages 18 to 100 · All sexes · Updated Jun 3, 2026 · NCT05658796

A Preventive Behavioral Intervention for Young Adults With Psychotic Experiences

Recruiting
Ages 18 to 30 · All sexes · Updated May 11, 2026 · NCT06929442

Examining the Effects of Estradiol on Neural and Molecular Response to Reward

RecruitingPhase 4
Ages 45 to 55 · Women · Updated Apr 29, 2026 · NCT05282277

Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study

RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 29, 2026 · NCT06897670

Optimizing an Integrated Mind and Body Treatment for Insomnia: The SLEEPS Study 2

Recruiting
Ages 18 and older · All sexes · Updated Apr 24, 2026 · NCT07036705

Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

RecruitingHealthy volunteers welcome
Ages 12 to 17 · Women · Updated Apr 22, 2026 · NCT05543083

Concurrent TMS-fMRI

RecruitingHealthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Mar 12, 2026 · NCT06633913

A Digitally Assisted Risk Reduction Platform for Youth at High Risk for Suicide

Recruiting
Ages 13 to 18 · All sexes · Updated Mar 4, 2026 · NCT05920252

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.