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Mood Disorders clinical trials recruiting in the U.S.
33 studies for Mood Disorders are recruiting participants at sites across the United States.
Most people feel sad or irritable sometimes. They may say they're in a bad mood. But mood disorders affect your everyday emotional state. Learn more.
Cities with the most studies
- Washington, DC6 studies
- Boston, MA5 studies
- Durham, NC4 studies
- Atlanta, GA3 studies
- Philadelphia, PA3 studies
- New York City, NY3 studies
By state
- California6 studies
- Colorado3 studies
- Florida3 studies
- Georgia3 studies
- Maryland8 studies
- Massachusetts5 studies
- New York6 studies
- North Carolina4 studies
- Ohio3 studies
- Pennsylvania6 studies
- Texas3 studies
- Utah3 studies
- Washington3 studies
Recently updated studies
Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Nov 12, 2026 · NCT00397111A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Nov 10, 2026 · NCT07065240A Study of Brenipatide in Adult Participants With Major Depressive Disorder
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Nov 4, 2026 · NCT07412756A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Nov 3, 2026 · NCT07775300Single Session Personalized Aperiodic Transcranial Alternating Current Stimulation (PandA-tACS) for Antenatal Depression
Recruiting
Ages 18 to 45 · Women · Updated Nov 3, 2026 · NCT07799480Characterization and Treatment of Adolescent Depression
RecruitingObservational studyHealthy volunteers welcome
Ages 11 to 25 · All sexes · Updated Oct 26, 2026 · NCT03388606NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
RecruitingObservational studyHealthy volunteers welcome
Ages 8 to 70 · All sexes · Updated Oct 7, 2026 · NCT05669703Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Oct 5, 2026 · NCT06511908Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
RecruitingObservational studyHealthy volunteers welcome
Ages 3 to 99 · All sexes · Updated Oct 2, 2026 · NCT00024635Studies of Brain Function and Course of Illness in Pediatric Bipolar Disorder
RecruitingObservational study
Ages 7 to 85 · All sexes · Updated Sep 23, 2026 · NCT00025935Anxiety Skills Study
Recruiting
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT07774481Digital Mental Health for Asian Americans
RecruitingHealthy volunteers welcome
Ages 18 to 90 · All sexes · Updated Aug 18, 2026 · NCT07771322A Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents
Recruiting
Ages 13 to 24 · All sexes · Updated Aug 12, 2026 · NCT07348666Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Jul 16, 2026 · NCT06376734The Impact of Enhanced Music & Natural Visuals on Emotional Health
RecruitingHealthy volunteers welcome
Ages 13 and older · All sexes · Updated Jun 30, 2026 · NCT07676110Phase II: Engagement and Clinical Impact of the Teleo Virtual Therapy Platform in Clinical Settings
Recruiting
Ages 5 to 14 · All sexes · Updated Jun 29, 2026 · NCT07155707CARED : A Novel Rapid Treatment Paradigm for Depression
Recruiting
Ages 18 to 70 · All sexes · Updated Jun 25, 2026 · NCT07507370RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty
Recruiting
Ages 18 to 100 · All sexes · Updated Jun 3, 2026 · NCT05658796Clinical Study Evaluating Pharmacogenomics-informed Pharmacotherapy Versus Dosing as Usual in Psychiatric Disorders
Recruiting
Ages 16 to 70 · All sexes · Updated Jun 2, 2026 · NCT05656469A Preventive Behavioral Intervention for Young Adults With Psychotic Experiences
Recruiting
Ages 18 to 30 · All sexes · Updated May 11, 2026 · NCT06929442Examining the Effects of Estradiol on Neural and Molecular Response to Reward
RecruitingPhase 4
Ages 45 to 55 · Women · Updated Apr 29, 2026 · NCT05282277Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study
RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 29, 2026 · NCT06897670Optimizing an Integrated Mind and Body Treatment for Insomnia: The SLEEPS Study 2
Recruiting
Ages 18 and older · All sexes · Updated Apr 24, 2026 · NCT07036705Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
RecruitingHealthy volunteers welcome
Ages 12 to 17 · Women · Updated Apr 22, 2026 · NCT05543083Concurrent TMS-fMRI
RecruitingHealthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Mar 12, 2026 · NCT06633913From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.