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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome clinical trials recruiting in the U.S.

13 studies for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome are recruiting participants at sites across the United States.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a long-term illness. It causes severe fatigue and many other symptoms. Learn about managing them.

By state

Recently updated studies

Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and Effort

RecruitingEarly phase 1
Ages 18 to 50 · All sexes · Updated Sep 18, 2026 · NCT06472622

ME/CFS Brain Fog: Cognitive Rehabilitation Trial

Recruiting
Ages 18 and older · All sexes · Updated Aug 14, 2026 · NCT07523113

Controlled Trial of Hydrogen Water as a Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Recruiting
Ages 18 to 65 · All sexes · Updated Aug 7, 2026 · NCT07753122

Testosterone Replacement in Male Cancer Survivors With Fatigue and Low Testosterone

RecruitingPhase 2
Ages 18 to 54 · Men · Updated Jun 22, 2026 · NCT04049331

Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Jun 2, 2026 · NCT03759522

A Study Of Remote Voice Analysis Tool For Diagnosing And Monitoring ME/CFS

RecruitingObservational study
Ages 18 and older · All sexes · Updated May 27, 2026 · NCT07551999

Chronic Infections and Inflammation in ME/CFS: An Observational Study

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Mar 6, 2026 · NCT07227441

Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research

RecruitingObservational studyHealthy volunteers welcome
Ages 2 and older · All sexes · Updated Jan 22, 2026 · NCT04806620

LIFT: Life Improvement Trial

RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Oct 22, 2025 · NCT06366724

Hydrogen Water Intervention With Heart Rate Variability as an Outcome Biomarker in ME/CFS

Recruiting
Ages 18 to 65 · All sexes · Updated Jun 8, 2025 · NCT07009691

The Long COVID-19 Wearable Device Study

Recruiting
Ages 18 and older · All sexes · Updated May 11, 2025 · NCT05741112

The Use of Directed Probiotics in ME/CFS: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

RecruitingPhase 2
Ages 45 to 70 · All sexes · Updated Mar 4, 2025 · NCT06211062

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.