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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome clinical trials recruiting in the U.S.
14 studies for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome are recruiting participants at sites across the United States.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a long-term illness. It causes severe fatigue and many other symptoms. Learn about managing them.
By state
Recently updated studies
Exploring the Extended Efficacy and Initial Use of RUCONEST® in Managing Neurological Symptoms Linked to Infectious Pathogens
RecruitingPhase 4
Ages 18 to 90 · All sexes · Updated Nov 12, 2026 · NCT07932002ME/CFS Brain Fog: Cognitive Rehabilitation Trial
Recruiting
Ages 18 and older · All sexes · Updated Oct 29, 2026 · NCT07523113LIFT: Life Improvement Trial
RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Oct 15, 2026 · NCT06366724Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and Effort
RecruitingEarly phase 1
Ages 18 to 50 · All sexes · Updated Sep 18, 2026 · NCT06472622Controlled Trial of Hydrogen Water as a Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Recruiting
Ages 18 to 65 · All sexes · Updated Aug 7, 2026 · NCT07753122Testosterone Replacement in Male Cancer Survivors With Fatigue and Low Testosterone
RecruitingPhase 2
Ages 18 to 54 · Men · Updated Jun 22, 2026 · NCT04049331Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.
RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Jun 2, 2026 · NCT03759522A Study Of Remote Voice Analysis Tool For Diagnosing And Monitoring ME/CFS
RecruitingObservational study
Ages 18 and older · All sexes · Updated May 27, 2026 · NCT07551999Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Mar 13, 2026 · NCT06511050Chronic Infections and Inflammation in ME/CFS: An Observational Study
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Mar 6, 2026 · NCT07227441Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
RecruitingObservational studyHealthy volunteers welcome
Ages 2 and older · All sexes · Updated Jan 22, 2026 · NCT04806620Hydrogen Water Intervention With Heart Rate Variability as an Outcome Biomarker in ME/CFS
Recruiting
Ages 18 to 65 · All sexes · Updated Jun 8, 2025 · NCT07009691The Long COVID-19 Wearable Device Study
Recruiting
Ages 18 and older · All sexes · Updated May 11, 2025 · NCT05741112The Use of Directed Probiotics in ME/CFS: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
RecruitingPhase 2
Ages 45 to 70 · All sexes · Updated Mar 4, 2025 · NCT06211062From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.