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Hydrogen Water Intervention With Heart Rate Variability as an Outcome Biomarker in ME/CFS

Recruiting

Heart Rate Variability as an Autonomic Marker of Improvement in ME/CFS in a Hydrogen Water Treatment Study

Who can join

Ages 18 to 65 · All sexes

Full eligibility criteria
Inclusion Criteria: Meets Institute of Medicine criteria for myalgic encephalomyelitis/chronic fatigue syndrome -

Exclusion Criteria: Medical illness that explains presenting fatigue; Any psychosis.

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About the study

The goal of this clinical trial is to learn if the OTC supplement, hydrogen water, works to treat the fatigue-related symptoms and functional limitations in adults with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). It will also examine if heart rate variability (HRV) can be used to predict who will benefit from the hydrogen water treatment. The main questions it aims to answer are:

Does the OTC supplement, hydrogen water, work to reduce the fatigue-related symptoms and improve functioning in participants who have ME/CFS?

Can HRV be used to predict who will benefit from treatment with hydrogen water?

What is being tested

Sponsor: Stony Brook University · Participants: 50 · Started: Jun 9, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT07009691

Locations in the U.S.

New YorkStony Brook University, Stony Brook

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.