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Non-Small Cell Lung Cancer clinical trials in Colorado
72 studies for Non-Small Cell Lung Cancer are looking for participants at sites in Colorado.
Cities in Colorado
- Aurora31 studies
- Denver25 studies
- Centennial14 studies
- Colorado Springs9 studies
- Grand Junction9 studies
- Boulder7 studies
- Arvada7 studies
- Highlands Ranch6 studies
- Lakewood5 studies
- Greeley5 studies
- Fort Collins5 studies
- Loveland5 studies
- Thornton4 studies
- Pueblo4 studies
- Longmont3 studies
- Westminster3 studies
A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Non-Small Cell Lung Cancer
- University of Colorado Cancer Center, Aurora
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT07659782Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-based Chemotherapy With or Without Amivantamab for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)
- Shaw Cancer Center, Edwards
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07100080This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.
- Intermountain Health Cancer Center Lutheran Hospital, Golden
- Cancer Centers of Colorado St. Mary's Regional Hospital, Grand Junction
- Intermountain Health St. Mary's Regional Hospital, Grand Junction
- and 2 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06758401Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial
- Kaiser Permanente-Franklin, Denver
- Saint Mary's Hospital and Regional Medical Center, Grand Junction
- Kaiser Permanente-Rock Creek, Lafayette
- and 1 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06498635Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
- Rocky Mountain Cancer Centers-Aurora, Aurora
- UCHealth University of Colorado Hospital, Aurora
- Rocky Mountain Cancer Centers-Boulder, Boulder
- and 13 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT04267848Trial of Therapeutic Cancer Vaccine OSE2101 in Patients With Non-Small Cell Lung Cancer and Secondary Resistance to Immune Checkpoint Inhibitor
- Lutheran Medical Center - Cancer Centers of Colorado, Wheat Ridge
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06472245A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors
- UCHealth Cancer Center - Anschutz Medical Campus - University of Colorado Cancer Center, Aurora
- Sarah Cannon Research Institute at HCA HealthONE Presbyterian St. Luke's, Denver
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06914128A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types
- Sarah Cannon Research Institute at HealthONE, Denver
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07503808Study of Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib Versus Osimertinib Monotherapy or Osimertinib in Combination With Platinum-based Chemotherapy for EGFRmt Non-small Cell Lung Cancer (IZABRIGHT-Lung02)
- Rocky Mountain Cancer Centers, Boulder
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07680790Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations
- Research Site, Grand Junction
- Research Site, Wheat Ridge
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07291037A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)
- University of Colorado Anschutz Medical Campus ( Site 0151), Aurora
- UCHealth Memorial Hospital Central ( Site 0125), Colorado Springs
- Banner MD Anderson Cancer Center at North Colorado Medical Center ( Site 0207), Greeley
- and 1 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 9, 2026 · NCT06623422A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)
- University of Colorado Cancer Center ( Site 3268), Aurora
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 9, 2026 · NCT07513376A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%
- Local Institution - 0500, Grand Junction
- Local Institution - 0472, Westminster
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 9, 2026 · NCT06561386A Study of ERAS-0015 in Patients With Advanced or Metastatic Solid Tumors
- University of Colorado, Aurora
RecruitingPhase 1
Ages 18 to 99 · All sexes · Updated Nov 6, 2026 · NCT06983743Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
- Valkyrie Clinical Trials - Colorado, Lakewood
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT04198766A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)
- Rocky Mountain Cancer Centers LLP, Aurora
- Rocky Mountain Cancer Centers LLP, Boulder
- Rocky Mountain Cancer Centers LLP, Centennial
- and 11 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07144280A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
- UC Health Oncology Research, Colorado Springs
- Poudre Valley Health Care, Inc. d/b/a Poudre Valley Health System, Fort Collins
- Grand Valley Oncology, Grand Junction
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT06793215A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)
- Intermountain Health Cancer Center Lutheran Hospital, Golden
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07361497A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
- Sarah Cannon Research Institute at HealthOne, Denver
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06465069Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
- Rocky Mountain Cancer Centers-Aurora, Aurora
- Rocky Mountain Cancer Centers-Boulder, Boulder
- Rocky Mountain Cancer Centers - Centennial, Centennial
- and 15 more
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06418204A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
- USO - Rocky Mountain Cancer Centers, Lone Tree
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06119581A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors
- Rocky Mountain Cancer Center, Littleton
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06695845A Study of Targeted Post-Surgery Radiation Therapy for Non-Small Cell Lung Cancer With Remaining Lymph Node Cancer After Treatment
- AdventHealth Parker, Parker
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07293247Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)
- Cancer Centers of Colorado St. Mary's Regional Hospital ( Site 0132), Grand Junction
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT06170788Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers
- University of Colorado Cancer Center at UC Health Sciences Center, Aurora
RecruitingObservational study
Ages 21 to 90 · All sexes · Updated Nov 3, 2026 · NCT00900419A Safety and Efficacy Study of EIK1001 in Combination With Pembrolizumab and Chemotherapy in Participants With Stage 4 Non-Small Cell Lung Cancer.
- Rocky Mountain Cancer Centers, LLP, Pueblo
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07365319A Study to Investigate the Safety and Efficacy of KQB365 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies
- Sarah Cannon Cancer Institute at HealthONE, Denver
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT06720987Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer (ROSETTA Lung-02)
- Vail Health, Vail
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT06712316Study to Evaluate Efficacy and Safety of Firmonertinib Compared With Investigator's Choice of EGFR Inhibitor as First-Line Treatment in Participants Who Have Locally Advanced or Metastatic NSCLC With EGFR P-Loop and Alpha C-Helix Compressing (PACC) Uncommon Mutations
- University of Colorado Health, Aurora
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT07185997Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
- Local Institution - 007-872-H, Aurora
- Local Institution - 007-872-D, Boulder
- Local Institution - 007-872-L, Centennial
- and 10 more
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT04613596DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors
- USA01-0, Wheat Ridge
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 29, 2026 · NCT06953089Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]
- Intermountain Health Cancer Center Lutheran Hospital ( Site 0119), Golden
- Intermountain Health St. Mary's Regional Hospital ( Site 0116), Grand Junction
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 29, 2026 · NCT06422143Study to Evaluate Adverse Events and Efficacy of Intravenous (IV) Telisotuzumab Adizutecan in Combination With a PD-1 Immune Checkpoint Inhibitor in Adult Participants With Advanced or Metastatic Non-Squamous NSCLC With No Prior Treatment for Advanced Disease, and No Actionable Genomic Alterations
- University Of Colorado - Anschutz Medical Campus /ID# 269069, Aurora
- Rocky Mountain Cancer Centers - Lone Tree /ID# 272603, Lone Tree
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT06772623A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
- National Jewish Health Medical Center, Denver
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT06875310A Study of Gilteritinib in Adults With Advanced ALK-positive Non-small Cell Lung Cancer (NSCLC)
- Vail Health Hospital - Shaw Cancer Center, Edwards
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 23, 2026 · NCT07140016A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)
- Local Institution - 0340, Lakewood
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 23, 2026 · NCT07361510Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors
- Sarah Cannon Research Institute, Denver
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 15, 2026 · NCT06239194SMP-3124LP in Adults With Advanced Solid Tumors
- Sarah Cannon Research Institute at HealthOne, Denver
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 15, 2026 · NCT06526819KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors
- Sarah Cannon Research Institute at HealthONE, Denver
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 14, 2026 · NCT06026410Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
- University of Colorado - Aurora Cancer Center, Aurora
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 13, 2026 · NCT05786924From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.