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Oral Cancer clinical trials recruiting in the U.S.
44 studies for Oral Cancer are recruiting participants at sites across the United States.
Oral cancer can form in the mouth or throat but usually begins in the tongue and floor of the mouth. Read about the common oral cancer symptoms.
Cities with the most studies
- Atlanta, GA9 studies
- New York City, NY8 studies
- Chicago, IL8 studies
- St. Louis, MO8 studies
- Durham, NC7 studies
- Kansas City, MO7 studies
- Milwaukee, WI7 studies
- Pittsburgh, PA7 studies
- Ann Arbor, MI7 studies
- Houston, TX7 studies
- Richmond, VA7 studies
- Edison, NJ6 studies
- Nashville, TN6 studies
- Philadelphia, PA6 studies
- Portland, OR6 studies
- Kansas City, KS6 studies
- Oklahoma City, OK6 studies
- Omaha, NE6 studies
- Queens, NY5 studies
- Decatur, IL5 studies
- Danville, IL5 studies
- Charleston, IL5 studies
- Detroit, MI5 studies
- Naperville, IL5 studies
- Champaign, IL5 studies
- Overland Park, KS5 studies
- Los Angeles, CA5 studies
- Mountain View, CA5 studies
- Erie, PA5 studies
- Phoenix, AZ5 studies
- Peoria, IL5 studies
- Wausau, WI5 studies
- Cedar Rapids, IA5 studies
- Joliet, IL5 studies
- Cape Girardeau, MO5 studies
- Bloomington, IL5 studies
- Stevens Point, WI5 studies
- Cincinnati, OH5 studies
- Baltimore, MD5 studies
- Toledo, OH4 studies
By state
- Arizona7 studies
- Arkansas5 studies
- California13 studies
- Colorado8 studies
- Connecticut3 studies
- Florida11 studies
- Georgia9 studies
- Idaho3 studies
- Illinois10 studies
- Indiana5 studies
- Iowa8 studies
- Kansas9 studies
- Kentucky5 studies
- Louisiana3 studies
- Maryland6 studies
- Massachusetts5 studies
- Michigan9 studies
- Minnesota8 studies
- Missouri10 studies
- Montana4 studies
- Nebraska6 studies
- New Hampshire4 studies
- New Jersey8 studies
- New Mexico3 studies
- New York13 studies
- North Carolina9 studies
- North Dakota4 studies
- Ohio14 studies
- Oklahoma6 studies
- Oregon6 studies
- Pennsylvania10 studies
- South Carolina5 studies
- South Dakota4 studies
- Tennessee8 studies
- Texas9 studies
- Vermont3 studies
- Virginia7 studies
- Wisconsin9 studies
Recently updated studies
Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06589804Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States Population
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06997068Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07195734DESTINY-PANTUMOUR04
RecruitingObservational study
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT05136196Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06980038Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT05172245Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT06736379Study to Identify Biomarkers of Oral Cavity Cancer Response to Neoadjuvant Immunotherapy Prior to Definitive Surgery
Recruiting
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT07343596Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT02734537Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT07156227Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT04333537Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT06532279Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT07441681Tongue Proactive Strengthening Exercise Program Following Partial/Hemi Glossectomy and Reconstruction
Recruiting
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT07110142Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT06627270Window Trial of Fluorescently Labeled Panitumumab (Panitumumab-IRDye800) in Head and Neck Cancer
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 3, 2026 · NCT06819228Personalized Neck Radiation Therapy Directed by Sentinel Lymph Node Biopsy for the Treatment of Oral Cavity Squamous Cell Carcinoma, PRECEDENT Trial
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT07121595Cemiplimab and Cetuximab Prior Salvage Surgery in Patients With Recurrent Oral Cavity and HPV-negative Oropharyngeal Squamous Cell Carcinoma
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT06448026Wide-Field and High Resolution In Vivo Imaging in Visualizing Lesions in Patients With Oral Neoplasia Undergoing Surgery
Recruiting
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT01269190Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT04198766Role of Acetaldehyde in the Development of Oral Cancer
RecruitingHealthy volunteers welcome
Ages 18 to 45 · All sexes · Updated Jul 22, 2026 · NCT05973656Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation
Recruiting
Ages 18 and older · All sexes · Updated Jul 16, 2026 · NCT06662058Safety and Feasibility of Nivolumab-IRDye800CW in Patients With Head and Neck Squamous Cell Carcinoma (HNSCC)
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT07460765Integrated Cancer Repository for Cancer Research
RecruitingObservational studyHealthy volunteers welcome
Ages 19 to 110 · All sexes · Updated Jun 29, 2026 · NCT02012699From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.