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Osteosarcoma clinical trials recruiting in the U.S.

52 studies for Osteosarcoma are recruiting participants at sites across the United States.

Cities with the most studies

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Recently updated studies

Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors

RecruitingPhase 1/2
Up to age 30 ยท All sexes ยท Updated Nov 12, 2026 ยท NCT06541262

Safety and Feasibility of Intraoperative Visualization With Cytalux in Children

RecruitingPhase 1
Ages 6 to 17 ยท All sexes ยท Updated Nov 12, 2026 ยท NCT06235125

Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases

RecruitingPhase 1
Ages 12 to 50 ยท All sexes ยท Updated Nov 10, 2026 ยท NCT03093909

The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma

RecruitingPhase 2
Ages 7 to 22 ยท All sexes ยท Updated Nov 4, 2026 ยท NCT07560826

Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors

RecruitingPhase 1
7 Months โ€“ 21 Years ยท All sexes ยท Updated Oct 27, 2026 ยท NCT02508038

AOH1996 for the Treatment of Refractory Solid Tumors

RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Oct 20, 2026 ยท NCT05227326

Tegavivint With Gemcitabine in Patients With Relapsed or Refractory Osteosarcoma

RecruitingPhase 1
Ages 1 to 30 ยท All sexes ยท Updated Oct 19, 2026 ยท NCT07144254

Study to Assess Safety and Efficacy of Vactosertib in Adolescents and Adults With Recurrent, Refractory or Progressive Osteosarcoma

RecruitingPhase 1/2
Ages 12 and older ยท All sexes ยท Updated Oct 7, 2026 ยท NCT05588648

Atezolizumab and Cabozantinib for the Treatment of Adolescents and Young Adults With Recurrent or Metastatic Osteosarcoma, TACOS Study

RecruitingPhase 2
Ages 12 and older ยท All sexes ยท Updated Oct 6, 2026 ยท NCT05019703

Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma

RecruitingPhase 2
Ages 0 to 50 ยท All sexes ยท Updated Oct 6, 2026 ยท NCT07321912

Atezolizumab in Combination With Stereotactic Body Radiation Therapy (SBRT) and Surgery for Relapsed Osteosarcoma

RecruitingPhase 1
Up to age 50 ยท All sexes ยท Updated Sep 30, 2026 ยท NCT06492954

Domatinostat With Sirolimus for Relapsed, Refractory Sarcoma and Osteosarcoma

RecruitingPhase 1/2
Ages 12 to 40 ยท All sexes ยท Updated Sep 3, 2026 ยท NCT07725380

Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas

RecruitingPhase 1/2
Up to age 26 ยท All sexes ยท Updated Sep 3, 2026 ยท NCT06465199

Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas

RecruitingPhase 1
Ages 5 to 40 ยท All sexes ยท Updated Sep 3, 2026 ยท NCT06156410

Clinical Orthopaedic Data Bank (Acute and Chronic)

RecruitingObservational study
All ages ยท All sexes ยท Updated Sep 3, 2026 ยท NCT00411060

Losartan + Sunitinib in Treatment of Osteosarcoma

RecruitingPhase 1
Ages 10 and older ยท All sexes ยท Updated Sep 1, 2026 ยท NCT03900793

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

RecruitingPhase 1/2
12 Months โ€“ 30 Years ยท All sexes ยท Updated Aug 25, 2026 ยท NCT04851119

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

RecruitingPhase 3
Up to age 50 ยท All sexes ยท Updated Aug 25, 2026 ยท NCT05235165

Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's Lymphoma

Recruiting
All ages ยท All sexes ยท Updated Aug 21, 2026 ยท NCT07514819

SPEARHEAD-3 Pediatric Study

RecruitingPhase 1/2
Ages 2 to 21 ยท All sexes ยท Updated Aug 11, 2026 ยท NCT05642455

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.