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Osteosarcoma clinical trials recruiting in the U.S.

52 studies for Osteosarcoma are recruiting participants at sites across the United States.

Cities with the most studies

By state

Recently updated studies

The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma

RecruitingPhase 2
Ages 7 to 22 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT07560826

Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors

RecruitingPhase 1/2
Up to age 30 ยท All sexes ยท Updated Sep 3, 2026 ยท NCT06541262

Clinical Orthopaedic Data Bank (Acute and Chronic)

RecruitingObservational study
All ages ยท All sexes ยท Updated Sep 3, 2026 ยท NCT00411060

Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas

RecruitingPhase 1/2
Up to age 26 ยท All sexes ยท Updated Sep 3, 2026 ยท NCT06465199

Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas

RecruitingPhase 1
Ages 5 to 40 ยท All sexes ยท Updated Sep 3, 2026 ยท NCT06156410

Domatinostat With Sirolimus for Relapsed, Refractory Sarcoma and Osteosarcoma

RecruitingPhase 1/2
Ages 12 to 40 ยท All sexes ยท Updated Sep 3, 2026 ยท NCT07725380

Losartan + Sunitinib in Treatment of Osteosarcoma

RecruitingPhase 1
Ages 10 and older ยท All sexes ยท Updated Sep 1, 2026 ยท NCT03900793

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

RecruitingPhase 1/2
12 Months โ€“ 30 Years ยท All sexes ยท Updated Aug 25, 2026 ยท NCT04851119

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

RecruitingPhase 3
Up to age 50 ยท All sexes ยท Updated Aug 25, 2026 ยท NCT05235165

Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's Lymphoma

Recruiting
All ages ยท All sexes ยท Updated Aug 21, 2026 ยท NCT07514819

SPEARHEAD-3 Pediatric Study

RecruitingPhase 1/2
Ages 2 to 21 ยท All sexes ยท Updated Aug 11, 2026 ยท NCT05642455

Musculoskeletal Cancers Remote Monitoring and Care

Recruiting
Ages 18 and older ยท All sexes ยท Updated Aug 6, 2026 ยท NCT07129226

Disulfiram With Copper Gluconate and Liposomal Doxorubicin in Treatment-Refractory Sarcomas

RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Aug 6, 2026 ยท NCT05210374

Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors

RecruitingEarly phase 1
Ages 18 and older ยท All sexes ยท Updated Jul 31, 2026 ยท NCT07628634

AOH1996 for the Treatment of Refractory Solid Tumors

RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Jul 28, 2026 ยท NCT05227326

Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Jul 28, 2026 ยท NCT04040205

NKG2D.Zeta-NK Cell Conditioning With C7R.GD2.CAR-T Cells for Patients With Relapsed or Refractory Osteosarcoma or Neuroblastoma

RecruitingPhase 1
Ages 1 to 24 ยท All sexes ยท Updated Jul 21, 2026 ยท NCT07211737

Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases

RecruitingPhase 1
Ages 12 to 50 ยท All sexes ยท Updated Jul 15, 2026 ยท NCT03093909

Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma

RecruitingPhase 2
Ages 0 to 50 ยท All sexes ยท Updated Jul 9, 2026 ยท NCT07321912

Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors

RecruitingPhase 1/2
6 Months โ€“ 25 Years ยท All sexes ยท Updated Jun 30, 2026 ยท NCT06625190

Deep Phenotyping Gait Deficits in Orthopedic Manifestations of Pediatric Cancer Patients

RecruitingObservational studyHealthy volunteers welcome
Ages 5 to 20 ยท All sexes ยท Updated Jun 18, 2026 ยท NCT07502885

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.