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Osteosarcoma clinical trials recruiting in the U.S.
52 studies for Osteosarcoma are recruiting participants at sites across the United States.
Cities with the most studies
- Memphis, TN10 studies
- St. Louis, MO10 studies
- Atlanta, GA10 studies
- Boston, MA9 studies
- Mountain View, CA8 studies
- Houston, TX7 studies
- Chicago, IL7 studies
- Birmingham, AL7 studies
- Los Angeles, CA7 studies
- Tampa, FL6 studies
- Aurora, CO6 studies
- Washington, DC6 studies
- Philadelphia, PA6 studies
- New York City, NY6 studies
- Cincinnati, OH6 studies
- Durham, NC5 studies
- Dallas, TX5 studies
- Honolulu, HI5 studies
- The Bronx, NY5 studies
- Seattle, WA4 studies
- Oakland, CA4 studies
- Columbus, OH4 studies
- Harrisburg, PA4 studies
- Salt Lake City, UT4 studies
- San Diego, CA4 studies
- Gainesville, FL4 studies
- Orlando, FL4 studies
- Clifton, NJ4 studies
- San Francisco, CA4 studies
- Greenburgh, NY4 studies
- Queens, NY4 studies
- Cleveland, OH4 studies
- Baltimore, MD4 studies
- Orange, CA3 studies
- Baldwin Park, CA3 studies
- Miami, FL3 studies
- Detroit, MI3 studies
- Phoenix, AZ3 studies
- Providence, RI3 studies
- St. Petersburg, FL3 studies
By state
- Alabama7 studies
- Arizona5 studies
- Arkansas3 studies
- California18 studies
- Colorado6 studies
- Connecticut4 studies
- District of Columbia5 studies
- Florida10 studies
- Georgia10 studies
- Hawaii5 studies
- Illinois7 studies
- Louisiana3 studies
- Maryland5 studies
- Massachusetts9 studies
- Michigan6 studies
- Minnesota3 studies
- Missouri10 studies
- New Jersey6 studies
- New York11 studies
- North Carolina6 studies
- Ohio12 studies
- Oregon3 studies
- Pennsylvania9 studies
- Rhode Island3 studies
- South Carolina3 studies
- Tennessee12 studies
- Texas10 studies
- Utah4 studies
- Virginia3 studies
- Washington4 studies
- Wisconsin5 studies
Recently updated studies
Trastuzumab Deruxtecan (DS-8201a) for the Treatment of Recurrent or Refractory Osteosarcoma, Wilms Tumor, and Desmoplastic Small Round Cell Tumor
RecruitingPhase 2
Ages 12 to 39 ยท All sexes ยท Updated Sep 29, 2026 ยท NCT04616560The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma
RecruitingPhase 2
Ages 7 to 22 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT07560826Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors
RecruitingPhase 1/2
Up to age 30 ยท All sexes ยท Updated Sep 3, 2026 ยท NCT06541262Clinical Orthopaedic Data Bank (Acute and Chronic)
RecruitingObservational study
All ages ยท All sexes ยท Updated Sep 3, 2026 ยท NCT00411060Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas
RecruitingPhase 1/2
Up to age 26 ยท All sexes ยท Updated Sep 3, 2026 ยท NCT06465199Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas
RecruitingPhase 1
Ages 5 to 40 ยท All sexes ยท Updated Sep 3, 2026 ยท NCT06156410Domatinostat With Sirolimus for Relapsed, Refractory Sarcoma and Osteosarcoma
RecruitingPhase 1/2
Ages 12 to 40 ยท All sexes ยท Updated Sep 3, 2026 ยท NCT07725380Genetically Engineered Cells (FH-FOLR1 ST CAR T Cells) for the Treatment of Advanced Refractory or Recurrent/Progressive Osteosarcoma, FIERCe Trial
RecruitingPhase 1
Ages 1 to 75 ยท All sexes ยท Updated Sep 1, 2026 ยท NCT07227571Evaluating Efficacy of B7-H3-CAR T Cells Administered at the End of Upfront Map Chemotherapy in Patients With Newly Diagnosed High-Risk Osteosarcoma
RecruitingPhase 2
Up to age 21 ยท All sexes ยท Updated Sep 1, 2026 ยท NCT07428993Losartan + Sunitinib in Treatment of Osteosarcoma
RecruitingPhase 1
Ages 10 and older ยท All sexes ยท Updated Sep 1, 2026 ยท NCT03900793Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
RecruitingPhase 1/2
12 Months โ 30 Years ยท All sexes ยท Updated Aug 25, 2026 ยท NCT04851119Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma
RecruitingPhase 3
Up to age 50 ยท All sexes ยท Updated Aug 25, 2026 ยท NCT05235165Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's Lymphoma
Recruiting
All ages ยท All sexes ยท Updated Aug 21, 2026 ยท NCT07514819SPEARHEAD-3 Pediatric Study
RecruitingPhase 1/2
Ages 2 to 21 ยท All sexes ยท Updated Aug 11, 2026 ยท NCT05642455Musculoskeletal Cancers Remote Monitoring and Care
Recruiting
Ages 18 and older ยท All sexes ยท Updated Aug 6, 2026 ยท NCT07129226Disulfiram With Copper Gluconate and Liposomal Doxorubicin in Treatment-Refractory Sarcomas
RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Aug 6, 2026 ยท NCT05210374NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)
RecruitingPhase 1/2
Up to age 30 ยท All sexes ยท Updated Aug 3, 2026 ยท NCT06239272Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors
RecruitingEarly phase 1
Ages 18 and older ยท All sexes ยท Updated Jul 31, 2026 ยท NCT07628634AOH1996 for the Treatment of Refractory Solid Tumors
RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Jul 28, 2026 ยท NCT05227326Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Jul 28, 2026 ยท NCT04040205NKG2D.Zeta-NK Cell Conditioning With C7R.GD2.CAR-T Cells for Patients With Relapsed or Refractory Osteosarcoma or Neuroblastoma
RecruitingPhase 1
Ages 1 to 24 ยท All sexes ยท Updated Jul 21, 2026 ยท NCT07211737Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases
RecruitingPhase 1
Ages 12 to 50 ยท All sexes ยท Updated Jul 15, 2026 ยท NCT03093909Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma
RecruitingPhase 2
Ages 0 to 50 ยท All sexes ยท Updated Jul 9, 2026 ยท NCT07321912Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors
RecruitingPhase 1/2
6 Months โ 25 Years ยท All sexes ยท Updated Jun 30, 2026 ยท NCT06625190Deep Phenotyping Gait Deficits in Orthopedic Manifestations of Pediatric Cancer Patients
RecruitingObservational studyHealthy volunteers welcome
Ages 5 to 20 ยท All sexes ยท Updated Jun 18, 2026 ยท NCT07502885From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.