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Prader-Willi Syndrome clinical trials recruiting in the U.S.

8 studies for Prader-Willi Syndrome are recruiting participants at sites across the United States.

Prader-Willi Syndrome (PWS) is a rare genetic disorder. It causes poor muscle tone, low levels of sex hormones and a constant feeling of hunger.

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Recently updated studies

Regulating Together for Prader-Willi Syndrome: A Group Behavioral Therapy for Emotion Dysregulation

Recruiting
Ages 13 to 17 · All sexes · Updated Sep 2, 2026 · NCT07607730

A Study of Pitolisant in Patients With Prader-Willi Syndrome

RecruitingPhase 3
Ages 6 and older · All sexes · Updated Aug 25, 2026 · NCT06366464

A Study of CSTI-500 in Patients With Prader-Willi Syndrome

RecruitingPhase 2
Ages 13 to 50 · All sexes · Updated May 15, 2026 · NCT07348601

Impact of Bright Light Therapy on Prader-Willi Syndrome

Recruiting
Ages 6 to 88 · All sexes · Updated May 15, 2026 · NCT05939453

Physical Activity and Community EmPOWERment Project

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Feb 23, 2026 · NCT06740162

A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment

RecruitingPhase 1/2Healthy volunteers welcome
Ages 12 to 65 · All sexes · Updated Dec 22, 2025 · NCT06239116

Cerebellar TMS and Satiety in Prader-Willi Syndrome

Recruiting
Ages 18 to 64 · All sexes · Updated Dec 5, 2025 · NCT05938543

Tirzepatide in PWS, HO and GNSO

RecruitingPhase 4
Ages 18 to 26 · All sexes · Updated Sep 16, 2025 · NCT06901245

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.