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Prader-Willi Syndrome clinical trials recruiting in the U.S.
8 studies for Prader-Willi Syndrome are recruiting participants at sites across the United States.
Prader-Willi Syndrome (PWS) is a rare genetic disorder. It causes poor muscle tone, low levels of sex hormones and a constant feeling of hunger.
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Recently updated studies
Regulating Together for Prader-Willi Syndrome: A Group Behavioral Therapy for Emotion Dysregulation
Recruiting
Ages 13 to 17 · All sexes · Updated Sep 2, 2026 · NCT07607730A Study of Pitolisant in Patients With Prader-Willi Syndrome
RecruitingPhase 3
Ages 6 and older · All sexes · Updated Aug 25, 2026 · NCT06366464A Study of CSTI-500 in Patients With Prader-Willi Syndrome
RecruitingPhase 2
Ages 13 to 50 · All sexes · Updated May 15, 2026 · NCT07348601Impact of Bright Light Therapy on Prader-Willi Syndrome
Recruiting
Ages 6 to 88 · All sexes · Updated May 15, 2026 · NCT05939453Physical Activity and Community EmPOWERment Project
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Feb 23, 2026 · NCT06740162A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment
RecruitingPhase 1/2Healthy volunteers welcome
Ages 12 to 65 · All sexes · Updated Dec 22, 2025 · NCT06239116Cerebellar TMS and Satiety in Prader-Willi Syndrome
Recruiting
Ages 18 to 64 · All sexes · Updated Dec 5, 2025 · NCT05938543Tirzepatide in PWS, HO and GNSO
RecruitingPhase 4
Ages 18 to 26 · All sexes · Updated Sep 16, 2025 · NCT06901245From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.