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Cerebellar TMS and Satiety in Prader-Willi Syndrome

Noninvasive Neuromodulation of a Novel Cerebellar Satiety Circuit in Prader-Willi Syndrome

Who can join

Ages 18 to 64 · All sexes

Inclusion Criteria:

* Diagnosis of Prader-Willi syndrome

Exclusion Criteria:

* contraindications for TMS or MRI including :
* history of neurological disorder
* history of head trauma resulting in loss of consciousness
* history of seizures or diagnosis of epilepsy or first degree relative family history of epilepsy
* metal in brain or skull
* implanted devices such as a pacemaker, medication pump, nerve stimulator or ventriculoperitoneal shunt claustrophobic in MRI

About the study

This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study hyperphagia and satiety in Prader-Willi syndrome.

TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study, the investigators will be stimulating the brain to learn more about how TMS might improve hyperphagia in Prader-Willi syndrome.

What is being tested

• Repetitive Transcranial Magnetic Stimulation (rTMS) (device)

Sponsor: Brigham and Women's Hospital · Participants: 20 · Started: Sep 1, 2023

Contact the study team

• Laura Holsen, PhD · Phone: 617-525-8772

Official record on ClinicalTrials.gov — NCT05938543

Locations in the U.S.

Conditions

• Prader-Willi Syndrome

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.