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Premature Birth clinical trials recruiting in the U.S.

75 studies for Premature Birth are recruiting participants at sites across the United States.

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Recently updated studies

High-energy Human Milk Diets in the First Two Weeks After Birth to Reduce BPD in Extremely Preterm Infants

RecruitingPhase 1/2
1 Day – 3 Days · All sexes · Updated Sep 24, 2026 · NCT07307612

Improving Preterm Kidney Outcomes With Caffeine

RecruitingPhase 2
12 Hours – 96 Hours · All sexes · Updated Sep 18, 2026 · NCT07262060

Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care

Recruiting
0 Days – 9 Months · All sexes · Updated Sep 17, 2026 · NCT07738874

The Effects of Pacifier-Activated Lullaby on Oral Feeding Among Preterm Infants

RecruitingHealthy volunteers welcome
34 Weeks – 36 Weeks · All sexes · Updated Sep 15, 2026 · NCT07819734

Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age

RecruitingObservational study
30 Weeks – 83 Months · All sexes · Updated Sep 15, 2026 · NCT05336890

Prenatal Education on Environmental Exposures During Pregnancy Study (PEEPS)

RecruitingHealthy volunteers welcome
Ages 18 and older · Women · Updated Sep 14, 2026 · NCT07758114

Maternal Stress, Milk Composition, and Preterm Neurodevelopment

RecruitingObservational study
28 Weeks – 34 Weeks · All sexes · Updated Sep 14, 2026 · NCT05537454

Milk Volume Outcomes Following Oral Nicotinamide Riboside Supplementation in Mothers of Extremely Preterm Infants

RecruitingPhase 2/3Healthy volunteers welcome
Ages 18 and older · Women · Updated Sep 14, 2026 · NCT04614714

Donor Breast Milk 2

Recruiting
29 Weeks – 33 Weeks · All sexes · Updated Sep 11, 2026 · NCT07816601

Baby ABS (Abdominal Binder Study)

Recruiting
22 Weeks – 31 Weeks · All sexes · Updated Sep 11, 2026 · NCT07049900

Growing Little PEAPODS Study

RecruitingObservational study
22 Weeks – 32 Weeks · All sexes · Updated Aug 19, 2026 · NCT06226051

Evaluating Wearable Smart Sensors for Continuous Measurement of Vital Signs in ICU Patients

RecruitingObservational studyHealthy volunteers welcome
Up to age 18 · All sexes · Updated Aug 17, 2026 · NCT04723654

Limited Versus Extended Trophic Feeding (LET-FEED) Trial

RecruitingPhase 2/3Healthy volunteers welcome
Ages 0 to 2 · All sexes · Updated Aug 17, 2026 · NCT06893939

The Effects of Entrainment on Respiratory Stability and Cerebral Oxygenation in Preterm Infants

Recruiting
24 Weeks – 37 Weeks · All sexes · Updated Aug 13, 2026 · NCT05223192

DE-RESTRICT: Deimplementing Activity Restriction for Preterm Birth Prevention

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT07698483

Prospective Evaluation of Pathways for Preterm Birth

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 45 · Women · Updated Aug 4, 2026 · NCT05246579

Point-of-Care Ophthalmic Diagnostic Imaging of Retinopathy of Prematurity

RecruitingObservational study
24 Weeks – 34 Weeks · All sexes · Updated Aug 4, 2026 · NCT06612541

Standardized Application of Feeding Evaluations Using SMART Tool

Recruiting
Up to age 1 · All sexes · Updated Jul 29, 2026 · NCT07136610

Neonatal White Matter Injury Trial (WRAP)

RecruitingPhase 1
3 Weeks – 20 Weeks · All sexes · Updated Jul 28, 2026 · NCT07688746

Using Placental Pathology to Prevent Recurrent Adverse Pregnancy Outcomes: A Pilot Project

RecruitingPhase 2
Ages 18 to 60 · All sexes · Updated Jul 23, 2026 · NCT06004674

PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysplasia

RecruitingPhase 1/2
7 Days – 28 Days · All sexes · Updated Jul 14, 2026 · NCT07101640

The Effect of Sulfasalazine on CRH Levels in Pregnant Women

RecruitingPhase 2Healthy volunteers welcome
Ages 18 and older · Women · Updated Jul 9, 2026 · NCT05703425

Preventing Vulnerable Child Syndrome in the NICU With Cognitive Behavioral Therapy (PreVNT Trial)

RecruitingHealthy volunteers welcome
All ages · All sexes · Updated Jul 9, 2026 · NCT03906435

Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset

RecruitingObservational study
Ages 0 to 1 · All sexes · Updated Jul 6, 2026 · NCT05685745

Follow-up Visit of High Risk Infants

RecruitingObservational study
18 Months – 26 Months · All sexes · Updated Jul 1, 2026 · NCT00009633

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.