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Milk And Growth In Children (MAGIC) Born Very Preterm: A Randomized Trial
Recruiting
A Multicenter Randomized Clinical Trial Comparing Two Human Milk Volumes to Optimize Growth and Gut Health in Infants Born Very Preterm
Who can join
6 Hours – 4 Days · All sexes
Full eligibility criteria
Inclusion Criteria: * Gestational age between 27 0/7 and 31 6/7 weeks * Birthweight of 1500 grams or less * Human milk feeding during the first 14 days after birth * Full enteral feeding (120mL/kg/day or more) within the first 14 days after birth Exclusion Criteria: * Necrotizing enterocolitis stage 2 or greater * Spontaneous intestinal perforation * Major congenital/chromosomal anomalies * Terminal illness requiring limited or withheld support * Intention to restrict fluid intake after the first 14 postnatal days due to the presence of a symptomatic patent ductus arteriosus (PDA) * Any formula feeding within the first 14 days after birth
About the study
The goal of this multi-center randomized, parallel group trial is to determine the effect of human milk diets ranging between 180 and 200 mL/kg/day on the body composition outcomes of moderately preterm infants born between 27 and 31 weeks of gestation.
What is being tested
- Human milk (dietary supplement)
Sponsor: University of Alabama at Birmingham · Participants: 486 · Started: Sep 16, 2025
Contact the study team
- Ariel A. Salas, MD, MSPH · Phone: 205-934-4680
Official record on ClinicalTrials.gov — NCT06420531
Locations in the U.S.
| Alabama | University of Alabama at Birmingham, Birmingham |
| Mississippi | University of Mississippi Medical Center, Jackson (Not yet recruiting) |
| Texas | University of Texas Southwestern Medical Center at Dallas, Dallas (Not yet recruiting) University of Texas Health Science Center at Houston, Houston (Not yet recruiting) |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.