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Pulmonary Hypertension clinical trials recruiting in the U.S.

55 studies for Pulmonary Hypertension are recruiting participants at sites across the United States.

Pulmonary hypertension (PH) is high blood pressure in the arteries to your lungs. It makes your heart work harder, which can lead to heart failure.

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Recently updated studies

Natural History Study of Biomarkers in Pulmonary Arterial Hypertension

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Sep 28, 2026 · NCT01730092

Study of REGN13335 in Adult Participants With Pulmonary Arterial Hypertension (PAH)

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07318597

Early Intervention With Inhaled Treprostinil Among Patients With Exercise-Induced Pulmonary Hypertension (EPIH)

RecruitingEarly phase 1
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT07837830

Natural History of Sickle Cell Disease

RecruitingObservational study
Ages 2 to 90 · All sexes · Updated Sep 16, 2026 · NCT00081523

A Phase 3 Trial of Inhaled Mosliciguat in PH-ILD (PHrontier)

RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Sep 11, 2026 · NCT07816185

Study of TX000045 in Participants With Pulmonary Hypertension Due to Interstitial Lung Disease

RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Sep 8, 2026 · NCT07473700

A Phase 3 Study to Evaluate the Safety and Efficacy L606 in Participants With PH-ILD

RecruitingPhase 3
Ages 18 to 80 · All sexes · Updated Sep 2, 2026 · NCT07285655

A Study of Mosliciguat in Combination With Inhaled Treprostinil in PH-ILD

RecruitingPhase 2
Ages 18 to 85 · All sexes · Updated Sep 2, 2026 · NCT07333183

Understanding the Effects of Pulmonary Arterial Hypertension on Lean Muscle Mass

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT07132788

DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 26, 2026 · NCT06388421

Pulmonary Hypertension and Oxygen Saturation Targeting in Preterm Infants

RecruitingHealthy volunteers welcome
1 Month – 5 Months · All sexes · Updated Aug 26, 2026 · NCT06373289

Development of an Algorithm to Detect Pulmonary Hypertension Using an Electronic Stethoscope

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT05873387

Detecting Pulmonary Hypertension With the Eko CORE 500 Digital Stethoscope

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT07136623

Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE)

RecruitingPhase 4
28 Days · All sexes · Updated Aug 18, 2026 · NCT07322133

De-implementing Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia

RecruitingPhase 4
0 Months – 1 Month · All sexes · Updated Aug 18, 2026 · NCT05213676

HS235 Study in Obese Participants With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction (HFpEF)

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT07123779

Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis

RecruitingPhase 2
Ages 8 to 60 · All sexes · Updated Aug 14, 2026 · NCT03630211

Xenon MRI Pulm Hypertension

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Aug 10, 2026 · NCT04991454

The Benefits of Home Exercise in Pulmonary Hypertension Interstitial Lung Disease

Recruiting
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT07561034

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.