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Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension

Recruiting

MOMENTOUS Study (iMpact Of an Ecg ai ModEl oN The Diagnosis Of pUlmonary hypertenSion)

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* 18 years or older at the time of consent
* A known diagnosis of interstitial lung disease
* Diffusing capacity for carbon monoxide (DLCO) \<30% predicted, collected within 6 months prior to consent
* Willing and able to provide informed consent and undergo all study-specific procedures, including echo and RHC, if required

Exclusion Criteria:

* A known diagnosis of pulmonary hypertension (including patients prescribed a therapy specifically for pulmonary arterial hypertension (PAH))
* A RHC was completed within the previous 1 year or ordered and not yet completed at the time of consent
* LV ejection fraction ≤ 40% on most recent echo or cardiac MRI, if available
* Unclassifiable Tempus PH ECG risk result after up to 2 ECG acquisitions
* A contraindication to RHC exists (for example, pregnancy or mechanical right heart valve)
* Physician decision that if a patient is directed to RHC by the study protocol, the potential risks of RHC outweigh the potential benefits
* There is a severe concomitant illness limiting life expectancy to less than 6 months (at the discretion of the investigator)
* There is a medical or social factor that makes the patient a poor candidate for the study and/or unlikely to be able to comply with the study protocol or complete study procedures (at the discretion of the investigator)

About the study

MOMENTOUS is a multi-center, randomized study to prospectively evaluate the performance of an ECG-based AI device to predict whether participants with interstitial lung disease (ILD) are at high risk of undiagnosed pulmonary hypertension.

What is being tested

Sponsor: Tempus AI · Participants: 900 · Started: Jul 23, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT06911632

Locations in the U.S.

AlabamaUniversity of Alabama at Birmingham, Birmingham
ArizonaBanner University Medical Center, Phoenix
Dignity Health - St. Joseph's Hospital and Medical Center-Norton Thoracic Institute, Phoenix
CaliforniaHCA Riverside Community Hospital, Riverside
ColoradoNational Jewish Health, Denver
FloridaAdventHealth Orlando, Orlando
IllinoisNorthwestern University, Chicago
University of Illinois Health, Chicago
IndianaCommunity Health Network, Indianapolis
Indiana University Health Methodist Hospital, Indianapolis
KentuckyUniversity of Kentucky, Lexington
LouisianaWillis Knighton Health, Bossier City
Louisiana State University Health Shreveport, Shreveport
MassachusettsBrigham and Women's Hospital, Boston
MichiganUniversity of Michigan - Michigan Medicine, Ann Arbor
MinnesotaUniversity of Minnesota, Minneapolis
MississippiUniversity of Mississippi Medical Center, Jackson
MissouriHannibal Regional Healthcare System, Hannibal
Mercy Hospital Springfield, Springfield
NebraskaCHI Health Creighton University Medical Center - Bergan Mercy, Omaha
NevadaRenown Regional Medical Center, Reno
New MexicoUniversity of New Mexico, Albuquerque
New YorkUniversity of Buffalo, Buffalo
Weill Cornell University Medical College, New York
North CarolinaSoutheastern Research Center, Winston-Salem
OhioUniversity Hospitals Cleveland Medical Center, Cleveland
OklahomaUniversity of Oklahoma, Oklahoma City
PennsylvaniaTemple University of The Commonwealth System of Higher Education, Philadelphia
Thomas Jefferson University, Philadelphia
South CarolinaMedical University of South Carolina, Charleston
TennesseeUniversity of Tennessee, Knoxville
TexasBaylor University Medical Center, Dallas
Baylor College of Medicine, Houston
Houston Methodist Hospital, Houston
UtahUniversity of Utah, Salt Lake City
VirginiaVirginia Commonwealth University, Richmond
West VirginiaWest Virginia University Hospital, Morgantown

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.