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Smoking Reduction clinical trials recruiting in the U.S.
10 studies for Smoking Reduction are recruiting participants at sites across the United States.
Recently updated studies
Trauma-Informed Care for Smoking Cessation for Pregnancy
RecruitingHealthy volunteers welcome
Ages 18 and older · Women · Updated Sep 10, 2026 · NCT07129590Varenicline for Smoking Reduction in Veterans Not Ready To Quit
RecruitingPhase 4
Ages 21 and older · All sexes · Updated Aug 31, 2026 · NCT06966362A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT06693700Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children
RecruitingPhase 4
Ages 18 to 45 · Women · Updated Jul 13, 2026 · NCT04783857Leveraging Community Pharmacists to Optimize Smoking Cessation Services for Rural Smokers in Appalachia
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Apr 20, 2026 · NCT05660525E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder
RecruitingPhase 2
Ages 21 to 75 · All sexes · Updated Mar 11, 2026 · NCT05722561The Impact of Menthol Flavoring on Switching in Adult Menthol Smokers
RecruitingHealthy volunteers welcome
Ages 21 and older · All sexes · Updated Jan 23, 2026 · NCT05555069Switching to E-cigarettes in Smokers Not Interested in Quitting
RecruitingPhase 3Healthy volunteers welcome
Ages 21 and older · All sexes · Updated Dec 29, 2025 · NCT05703672A First in Human Single Ascending Dose (SAD) Study of ATI-1013 in Healthy Smokers
RecruitingPhase 1Healthy volunteers welcome
Ages 23 to 59 · All sexes · Updated Oct 15, 2025 · NCT07215923rTMS-concurrent Behavioral Priming for Reducing Smoking Cravings
Recruiting
Ages 18 to 60 · All sexes · Updated Apr 9, 2025 · NCT06228235From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.