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The Impact of Menthol Flavoring on Switching in Adult Menthol Smokers

Who can join

Ages 21 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* ≥ 21 years of age
* Smoke ≥ 5 cigarettes per day (CPD)
* Smoke menthol cigarettes for ≥ 6 months
* Verified smoker (CO \>5ppm)
* Functioning telephone
* Interested in switching to E-cigarettes

Exclusion Criteria:

* Interested in quitting smoking
* Use of other tobacco products in past 30 days (i.e. cigarillos, cigars, hookah, smokeless tobacco, pipes)
* E-cigarette use on ≥ 4 of the past 30 days
* Uncontrolled hypertension: BP ≥ 180(systolic) or ≥ 105 (diastolic)
* Use of smoking cessation pharmacotherapy in the month prior to enrollment
* Pregnant, contemplating getting pregnant, or breastfeeding
* Plans to move from Kansas City during the treatment and follow-up phase
* Another household member enrolled in the study

About the study

This study will compare the efficacy of menthol-flavored versus tobacco-flavored 4th generation nicotine salt-based pod-system e-cigarettes in facilitating a switch from combustible cigarettes to e-cigarettes in adult menthol smokers.

What is being tested

• Menthol-flavored electronic cigarette (other)
• Tobacco-flavored electronic cigarette (other)

Sponsor: Nikki Nollen, PhD, MA · Participants: 800 · Started: Nov 8, 2022

Contact the study team

• Tricia Snow · Phone: 816-398-8960

Official record on ClinicalTrials.gov — NCT05555069

Locations in the U.S.

Conditions

• Smoking Reduction

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.