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Squamous Cell Carcinoma clinical trials recruiting in the U.S.

56 studies for Squamous Cell Carcinoma are recruiting participants at sites across the United States.

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Recently updated studies

Reflectance Confocal Microscopy of Oral Cancers in Vivo: a Preliminary Trial Comparing Intra-oral Imaging With Pathology

RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT02507141

Phase 1 Study Of TROP2 CAR/IL-15 TGFBR2 KO NK Cell In Patients With Oral Premalignant Lesions

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT07631013

Window Trial of Intratumoral (IT) Neoadjuvant Fluorescently Labelled Nivolumab (nivo800) in Head and Neck Squamous Cell Carcinoma (HNSCC)

RecruitingEarly phase 1
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07741565

JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC

RecruitingPhase 3
Ages 60 and older · All sexes · Updated Nov 3, 2026 · NCT04892173

Basal Cell Carcinoma Chemoprevention Trial

RecruitingPhase 3Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT05212246

Safety and Tolerability of Metformin and Naproxen for Cancer Prevention in Fanconi Anemia

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT07901959

Ordastobart (INBRX-106) Add-on to Pembrolizumab in 1L HPV+ PD-L1+ R/M OPSCC (HexAgon-HN)

RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT06295731

Intratumoral N17350 in Advanced Solid Tumors

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 21, 2026 · NCT07339176

T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer

RecruitingPhase 2
Ages 18 to 72 · All sexes · Updated Oct 20, 2026 · NCT02133196

PDT For Induction Therapy For Head And Neck Cancer

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 19, 2026 · NCT07214987

Safety and Feasibility of Nivolumab-IRDye800CW in Patients With Head and Neck Squamous Cell Carcinoma (HNSCC)

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 16, 2026 · NCT07460765

Cemiplimab and Quad Shot Radiation for Cutaneous Squamous Cell Carcinoma in the Head and Neck

RecruitingEarly phase 1
Ages 18 and older · All sexes · Updated Oct 13, 2026 · NCT07869823

A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 8, 2026 · NCT07115043

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06047379

Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT06736379

Immunotherapy With Chemotherapy and Chemoradiation for Advanced Squamous Cancer of Nasal Cavity / Paranasal Sinuses (I-NAPA)

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT05027633

Effects of Infusion Timing on Treatment Response in Solid Tumors

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07630168

Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION)

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT07513389

A Study of IDP-001 in Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT07602842

Atorvastatin to Reduce Cisplatin-Induced Hearing Loss Among Individuals With Head and Neck Cancer

RecruitingPhase 2
Ages 18 to 100 · All sexes · Updated Sep 2, 2026 · NCT04915183

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.