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Reflectance Confocal Microscopy of Oral Cancers in Vivo: a Preliminary Trial Comparing Intra-oral Imaging With Pathology
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Patients with biopsy-proven oral SCC who are scheduled to undergo surgery in the MSK Head and Neck Service. * Ability to sign informed consent. * Age ≥ 18 years. Exclusion Criteria: * Cancer located on a site that may not be convenient or accessible for imaging with the current version of the RCM device (gingivobuccal region, back of the oral cavity, back of the tongue, floor of the mouth, deep under the tongue, etc.). * Inability to give informed consent.
About the study
The purpose of this study is to get images (pictures) of oral lesions, which occur inside the mouth, before the patient's surgery using a special camera. These pictures will be used in our research to evaluate a new technology that uses a laser and takes pictures of the microscopic structure of tissue. The technology is called "reflectance confocal microscopy." We would like to compare what the camera sees to biopsies (pathology) of the same area. We will evaluate the pictures obtained from the patient to determine whether this technology may be useful in the future. We hope this technology can be used as a tool for early diagnosis of oral cancers and for guiding surgery.
What is being tested
- Reflectance Confocal Microscopy (device)
Sponsor: Memorial Sloan Kettering Cancer Center · Participants: 140 · Started: Jul 21, 2015
Contact the study team
- Snehal Patel, MD · Phone: 212-639-3412
- Milind Rajadhyaksha, PhD · Phone: 646-888-6243
Official record on ClinicalTrials.gov — NCT02507141
Locations in the U.S.
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.