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Systolic Heart Failure clinical trials recruiting in the U.S.

14 studies for Systolic Heart Failure are recruiting participants at sites across the United States.

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Recently updated studies

A Study of LY3971297 in Participants With Heart Failure

RecruitingPhase 1
Ages 18 to 65 · All sexes · Updated Sep 22, 2026 · NCT07547540

Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure

Recruiting
Ages 21 and older · All sexes · Updated Aug 25, 2026 · NCT05677100

Neuromodulation of Inflammation and Endothelial Function

Recruiting
Ages 18 to 85 · All sexes · Updated Aug 11, 2026 · NCT05230732

Infusing Needed Iron to Target Insufficiency in Adults Treated for Evidence of Heart Failure

Recruiting
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT07467668

Paced Heart Rate Acceleration for Cardiac Conditioning

Recruiting
Ages 18 to 120 · All sexes · Updated Jun 25, 2026 · NCT06332391

The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)

Recruiting
Ages 18 and older · All sexes · Updated Apr 28, 2026 · NCT05427370

Developing a Digital Aid to Improve ICD Decisions

Recruiting
Ages 60 and older · All sexes · Updated Apr 27, 2026 · NCT07084142

Propensity-Matched Study of Cardiac Contractility Modulation Therapy in Heart Failure

RecruitingObservational study
Ages 18 and older · All sexes · Updated Mar 24, 2026 · NCT07209098

Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes

RecruitingEarly phase 1
Ages 18 to 80 · All sexes · Updated Jan 21, 2026 · NCT06108076

Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status

RecruitingObservational study
Ages 18 and older · All sexes · Updated Dec 24, 2025 · NCT06009276

Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance

RecruitingObservational study
Ages 18 and older · All sexes · Updated Dec 23, 2025 · NCT07131631

Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction

RecruitingPhase 1/2
Ages 18 to 80 · All sexes · Updated Mar 26, 2024 · NCT04703842

Mechanistic Clinical Trial of Advanced Imaging for CRT

Recruiting
Ages 20 to 90 · All sexes · Updated Feb 6, 2020 · NCT03398369

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.