Home › Systolic Heart Failure › NCT03398369

Mechanistic Clinical Trial of Advanced Imaging for CRT

Advanced Imaging and Inflammatory Markers to Define Mechanisms of Response to CRT

Who can join

Ages 20 to 90 · All sexes

Inclusion Criteria:

1. Chronic systolic HF
2. LVEF 35% or less
3. Guideline-based class I or II indication for CRT

Exclusion Criteria:

1. Inability to provide informed consent
2. Pregnancy
3. Presence of metal embedded in the body due to prior accident or injury, as documented by skull films or other imaging
4. Cerebral aneurysm clips
5. Cochlear implants
6. Other metallic implants known to be contraindications to CMR (does not include pacemakers and ICDs)
7. Severe claustrophobia
8. Acute kidney injury
9. Acute renal failure or chronic kidney disease with GFR \< 45 cc/min/1.73m2
10. Liver transplant
11. Gadolinium allergy
12. \>10% premature ventricular contraction (PVC) burden; and 13) estimated \>10% atrial fibrillation (AF) burden based on available clinical data.

About the study

This is a mechanistic clinical trial with randomization to guidance for the CRT procedure using cardiac magnetic resonance (CMR) and computed tomography angiography (CTA) versus a standard procedure.

What is being tested

• CMR/CTA Guidance for CRT (diagnostic test)

Sponsor: University of Virginia · Participants: 180 · Started: Jan 5, 2018

Contact the study team

• Kenneth C Bilchick, MD · Phone: 4349242465
• Hollis Phillips, BA · Phone: 434-243-0046

Official record on ClinicalTrials.gov — NCT03398369

Locations in the U.S.

Conditions

• Systolic Heart Failure

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.