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Treatment-Resistant Depressive Disorder clinical trials in California
12 studies for Treatment-Resistant Depressive Disorder are looking for participants at sites in California.
Cities in California
A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression
- Anderson Clinical Research, Redlands
- Artemis Institute for Clinical Research, San Diego
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07716098Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study
- UCSD Interventional Psychiatry, San Diego
Recruiting
Ages 18 to 85 · All sexes · Updated Sep 15, 2026 · NCT07217223ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
- Inland Psychiatric Medical Group, Chino
- Behavioral Research Specialists, LLC, Glendale
- Kadima Neuropsychiatry Institute, La Jolla
- and 1 more
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT07284667Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
- USC University Hospital, Los Angeles
- UCLA Department of Psychiatry, Los Angeles
- University of California at Davis, Sacramento
Recruiting
Ages 22 to 70 · All sexes · Updated Aug 28, 2026 · NCT06423430A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
- ATP Clinical Research, Inc., Costa Mesa
- Kaizen Brain Center, La Jolla
- Keck Hospital of USC, Los Angeles
Recruiting
Ages 18 and older · All sexes · Updated Jun 15, 2026 · NCT03887715A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
- CenExel, Garden Grove
- Behavioral Research Specialists, LLC, Glendale
- Kadima Neuropsychiatry Institute, La Jolla
- and 2 more
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated May 11, 2026 · NCT06524830Mindfulness Engaged Neurostimulation for Depression (MEND II)
- UC San Diego Health Psychiatry, San Diego
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated May 6, 2026 · NCT07512284Maintenance rTMS for Depression (Maitr-De)
- University of California, San Diego, San Diego
Recruiting
Ages 18 to 80 · All sexes · Updated Apr 29, 2026 · NCT06938841ALTO-207 in Adults With Treatment-resistant Depression (TRD)
- Site 7153, Chino
- Site 7156, Oakland
- Site 7082, Oceanside
- and 4 more
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Apr 28, 2026 · NCT07553637ATLAS-1: Advanced Trial for Longitudinal Assessment in Salma 1
- Salma Health, La Jolla
- Salma Health, Laguna Hills
RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 14, 2026 · NCT07528014Biomarker-guided rTMS for Treatment Resistant Depression
- Stanford University, Stanford
RecruitingPhase 3
Ages 22 to 65 · All sexes · Updated Feb 25, 2026 · NCT04041479Cortical Inhibition as a Biomarker of Response in a Comparison of Bilateral Versus Unilateral Accelerated Theta Burst Stimulation for Suicidal Ideation in Treatment-Resistant Depression -COMBAT-SI
- UCSD Interventional Psychiatry, San Diego
Recruiting
Ages 18 to 70 · All sexes · Updated Nov 5, 2025 · NCT05377177From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.