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Treatment-Resistant Depressive Disorder clinical trials recruiting in the U.S.
33 studies for Treatment-Resistant Depressive Disorder are recruiting participants at sites across the United States.
Cities with the most studies
- San Diego, CA9 studies
- New York City, NY7 studies
- Houston, TX6 studies
- St. Louis, MO6 studies
- Austin, TX4 studies
- Dallas, TX4 studies
- Boston, MA3 studies
- Minneapolis, MN3 studies
- Columbus, OH3 studies
- Orlando, FL3 studies
- Atlanta, GA3 studies
- Salt Lake City, UT3 studies
- Los Angeles, CA3 studies
- Tampa, FL3 studies
- Sandy Springs, GA3 studies
- Rochester, MN3 studies
- Washington, DC3 studies
- Queens, NY3 studies
By state
- Alabama3 studies
- California12 studies
- Florida6 studies
- Georgia5 studies
- Illinois4 studies
- Maryland5 studies
- Massachusetts8 studies
- Minnesota5 studies
- Missouri7 studies
- New York10 studies
- Ohio5 studies
- South Carolina3 studies
- Texas8 studies
- Utah3 studies
Recently updated studies
DBS for Depression
Recruiting
Ages 18 to 65 · All sexes · Updated Nov 13, 2026 · NCT06096207Natural History of Depression, Bipolar Disorder and Suicide Risk
RecruitingObservational study
Ages 18 to 120 · All sexes · Updated Nov 9, 2026 · NCT06462196Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium
Recruiting
Ages 22 to 85 · All sexes · Updated Nov 9, 2026 · NCT07594483Biomarker-Guided Antidepressant Selection
RecruitingPhase 4
Ages 18 to 70 · All sexes · Updated Nov 6, 2026 · NCT07680140ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Nov 5, 2026 · NCT07284667A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Recruiting
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT03887715EEG-Guided Transcranial Magnetic Stimulation for Adults With Depression
Recruiting
Ages 22 to 60 · All sexes · Updated Nov 3, 2026 · NCT07862205A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07716098SAINT® Therapy for Memory Problems in Older Adults With Treatment-Resistant Depression
Recruiting
Ages 65 and older · All sexes · Updated Oct 28, 2026 · NCT07876908ALTO-207 in Adults With Treatment-resistant Depression (TRD)
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Oct 26, 2026 · NCT07553637A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial
RecruitingPhase 2/3
Ages 18 to 80 · All sexes · Updated Oct 21, 2026 · NCT07227103Intravenous Ketamine for Treatment-Resistant Depression
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Oct 16, 2026 · NCT06668571Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
Recruiting
Ages 22 to 70 · All sexes · Updated Oct 16, 2026 · NCT06423430Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Oct 5, 2026 · NCT06511908Long-term Observation of Participants With Mood Disorders
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 99 · All sexes · Updated Oct 1, 2026 · NCT04877977DBS for TRD With the Medtronic Percept PC
Recruiting
Ages 25 to 70 · All sexes · Updated Sep 22, 2026 · NCT05773755Lumateperone for Late-Life Depression
RecruitingPhase 3
Ages 60 and older · All sexes · Updated Sep 16, 2026 · NCT07623135Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
RecruitingPhase 1Healthy volunteers welcome
Ages 21 to 45 · All sexes · Updated Sep 15, 2026 · NCT06480201Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study
Recruiting
Ages 18 to 85 · All sexes · Updated Sep 15, 2026 · NCT07217223One-Day cTBS Over the Precuneus
Recruiting
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT07758010PCS in Severe Treatment Resistant Depression
Recruiting
Ages 22 to 70 · All sexes · Updated Sep 1, 2026 · NCT04124341Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression
Recruiting
Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT07563868Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression
Recruiting
Ages 21 to 70 · All sexes · Updated Jul 15, 2026 · NCT03952962Mindfulness Engaged Neurostimulation for Depression (MEND II)
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated May 6, 2026 · NCT07512284Maintenance rTMS for Depression (Maitr-De)
Recruiting
Ages 18 to 80 · All sexes · Updated Apr 29, 2026 · NCT06938841From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.