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Treatment-Resistant Depressive Disorder clinical trials recruiting in the U.S.

32 studies for Treatment-Resistant Depressive Disorder are recruiting participants at sites across the United States.

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Recently updated studies

A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07716098

Biomarker-Guided Antidepressant Selection

RecruitingPhase 4
Ages 18 to 70 · All sexes · Updated Sep 23, 2026 · NCT07680140

DBS for TRD With the Medtronic Percept PC

Recruiting
Ages 25 to 70 · All sexes · Updated Sep 22, 2026 · NCT05773755

Lumateperone for Late-Life Depression

RecruitingPhase 3
Ages 60 and older · All sexes · Updated Sep 16, 2026 · NCT07623135

Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression

RecruitingPhase 1Healthy volunteers welcome
Ages 21 to 45 · All sexes · Updated Sep 15, 2026 · NCT06480201

DBS for Depression

RecruitingPhase 1
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT06096207

ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT07284667

One-Day cTBS Over the Precuneus

Recruiting
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT07758010

PCS in Severe Treatment Resistant Depression

Recruiting
Ages 22 to 70 · All sexes · Updated Sep 1, 2026 · NCT04124341

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

Recruiting
Ages 22 to 70 · All sexes · Updated Aug 28, 2026 · NCT06423430

Natural History of Depression, Bipolar Disorder and Suicide Risk

RecruitingObservational study
Ages 18 to 120 · All sexes · Updated Aug 14, 2026 · NCT06462196

Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression

Recruiting
Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT07563868

Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression

Recruiting
Ages 21 to 70 · All sexes · Updated Jul 15, 2026 · NCT03952962

Mindfulness Engaged Neurostimulation for Depression (MEND II)

RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated May 6, 2026 · NCT07512284

Maintenance rTMS for Depression (Maitr-De)

Recruiting
Ages 18 to 80 · All sexes · Updated Apr 29, 2026 · NCT06938841

NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Apr 29, 2026 · NCT02994433

ALTO-207 in Adults With Treatment-resistant Depression (TRD)

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Apr 28, 2026 · NCT07553637

ATLAS-1: Advanced Trial for Longitudinal Assessment in Salma 1

RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 14, 2026 · NCT07528014

Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy

RecruitingObservational study
Ages 21 to 65 · All sexes · Updated Mar 12, 2026 · NCT05905705

University of Iowa Interventional Psychiatry Service Patient Registry

RecruitingObservational study
Ages 18 to 99 · All sexes · Updated Mar 3, 2026 · NCT04480918

Ultrasound Neuromodulation of Circuits and Negative Valence Systems in Treatment-Resistant Depression

Recruiting
Ages 18 to 65 · All sexes · Updated Mar 2, 2026 · NCT07166289

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.