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Treatment-Resistant Depressive Disorder clinical trials recruiting in the U.S.
32 studies for Treatment-Resistant Depressive Disorder are recruiting participants at sites across the United States.
Cities with the most studies
- San Diego, CA10 studies
- New York City, NY8 studies
- Houston, TX6 studies
- St. Louis, MO5 studies
- Tampa, FL4 studies
- Austin, TX4 studies
- Dallas, TX4 studies
- Atlanta, GA4 studies
- Columbus, OH3 studies
- Boston, MA3 studies
- Birmingham, AL3 studies
- Indianapolis, IN3 studies
- Minneapolis, MN3 studies
- Philadelphia, PA3 studies
- Chicago, IL3 studies
- Bellevue, WA3 studies
- Queens, NY3 studies
- Washington, DC3 studies
- Baltimore, MD3 studies
- O'Fallon, MO3 studies
By state
- Alabama3 studies
- Arizona3 studies
- California12 studies
- Florida5 studies
- Georgia5 studies
- Illinois4 studies
- Indiana3 studies
- Maryland6 studies
- Massachusetts7 studies
- Minnesota5 studies
- Missouri7 studies
- New York11 studies
- Ohio5 studies
- Pennsylvania3 studies
- Texas9 studies
- Utah3 studies
- Washington4 studies
Recently updated studies
A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07716098Biomarker-Guided Antidepressant Selection
RecruitingPhase 4
Ages 18 to 70 · All sexes · Updated Sep 23, 2026 · NCT07680140DBS for TRD With the Medtronic Percept PC
Recruiting
Ages 25 to 70 · All sexes · Updated Sep 22, 2026 · NCT05773755Lumateperone for Late-Life Depression
RecruitingPhase 3
Ages 60 and older · All sexes · Updated Sep 16, 2026 · NCT07623135Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study
Recruiting
Ages 18 to 85 · All sexes · Updated Sep 15, 2026 · NCT07217223Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
RecruitingPhase 1Healthy volunteers welcome
Ages 21 to 45 · All sexes · Updated Sep 15, 2026 · NCT06480201Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Sep 14, 2026 · NCT06511908DBS for Depression
RecruitingPhase 1
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT06096207ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT07284667One-Day cTBS Over the Precuneus
Recruiting
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT07758010PCS in Severe Treatment Resistant Depression
Recruiting
Ages 22 to 70 · All sexes · Updated Sep 1, 2026 · NCT04124341Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
Recruiting
Ages 22 to 70 · All sexes · Updated Aug 28, 2026 · NCT06423430Natural History of Depression, Bipolar Disorder and Suicide Risk
RecruitingObservational study
Ages 18 to 120 · All sexes · Updated Aug 14, 2026 · NCT06462196Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression
Recruiting
Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT07563868Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression
Recruiting
Ages 21 to 70 · All sexes · Updated Jul 15, 2026 · NCT03952962A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Recruiting
Ages 18 and older · All sexes · Updated Jun 15, 2026 · NCT03887715A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated May 11, 2026 · NCT06524830Mindfulness Engaged Neurostimulation for Depression (MEND II)
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated May 6, 2026 · NCT07512284Maintenance rTMS for Depression (Maitr-De)
Recruiting
Ages 18 to 80 · All sexes · Updated Apr 29, 2026 · NCT06938841NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits
RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Apr 29, 2026 · NCT02994433ALTO-207 in Adults With Treatment-resistant Depression (TRD)
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Apr 28, 2026 · NCT07553637ATLAS-1: Advanced Trial for Longitudinal Assessment in Salma 1
RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 14, 2026 · NCT07528014Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy
RecruitingObservational study
Ages 21 to 65 · All sexes · Updated Mar 12, 2026 · NCT05905705University of Iowa Interventional Psychiatry Service Patient Registry
RecruitingObservational study
Ages 18 to 99 · All sexes · Updated Mar 3, 2026 · NCT04480918Ultrasound Neuromodulation of Circuits and Negative Valence Systems in Treatment-Resistant Depression
Recruiting
Ages 18 to 65 · All sexes · Updated Mar 2, 2026 · NCT07166289From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.