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Treatment-Resistant Depressive Disorder clinical trials in Massachusetts
8 studies for Treatment-Resistant Depressive Disorder are looking for participants at sites in Massachusetts.
Cities in Massachusetts
ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
- Adams Clinical, Inc., Watertown
- Vitalix Clinical, Inc., Worcester
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Nov 5, 2026 · NCT07284667A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
- Massachusetts General Hospital, Boston
Recruiting
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT03887715A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression
- Adams Clinical Watertown, Watertown
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07716098ALTO-207 in Adults With Treatment-resistant Depression (TRD)
- Site 7166, Worcester
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Oct 26, 2026 · NCT07553637A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial
- Harvard Mclean Hospital, Belmont
RecruitingPhase 2/3
Ages 18 to 80 · All sexes · Updated Oct 21, 2026 · NCT07227103Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
- Massachusetts General Hospital, Boston
- Beth Israel Deaconess Medical Center, Boston
Recruiting
Ages 22 to 70 · All sexes · Updated Oct 16, 2026 · NCT06423430One-Day cTBS Over the Precuneus
- McLean Hospital, Belmont
Recruiting
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT07758010Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression
- Massachusetts General Hospital's Depression and Clinical Research program, Boston
- Massachusetts General Hospital, Boston
Recruiting
Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT07563868From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.