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Vaso-Occlusive Crises clinical trials recruiting in the U.S.
7 studies for Vaso-Occlusive Crises are recruiting participants at sites across the United States.
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Recently updated studies
A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)
RecruitingPhase 3
Ages 12 to 100 · All sexes · Updated Sep 28, 2026 · NCT06439082Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults
RecruitingPhase 2
Ages 5 to 20 · All sexes · Updated Sep 2, 2026 · NCT07369024Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
RecruitingPhase 2
Ages 12 and older · All sexes · Updated Aug 14, 2026 · NCT06699849Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT07224360Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Study
RecruitingPhase 4
6 Months – 100 Years · All sexes · Updated Jun 8, 2026 · NCT04657822Effect of Virtual Reality Technology for Pain Management of Vaso-Occlusive Crisis in Patients With Sickle Cell Disease
Recruiting
Ages 6 to 25 · All sexes · Updated May 18, 2026 · NCT03353584Sickle Cell Improvement: Enhancing Care in the Emergency Department
Recruiting
Up to age 18 · All sexes · Updated Aug 14, 2023 · NCT05373771From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.