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Sickle Cell Improvement: Enhancing Care in the Emergency Department
Who can join
Up to age 18 · All sexes
Full eligibility criteria
Inclusion Criteria: * ED visit for uncomplicated pain crisis * Sickle cell disease * Receipt of at least one opioid Exclusion Criteria: * Acute chest syndrome * Fever \> 38.5 in the ED * priapism * sickle cell trait
About the study
Sickle cell disease (SCD) is an inherited blood disorder affecting approximately 36,000 children in the United States, approximately 90% of whom are Black. The disease is characterized by recurrent, severe pain crises which result in high rates of emergency department visits and hospitalizations, and decreased quality of life. The National Heart, Lung and Blood Institute, as well as the American Society of Hematology, have endorsed pain management guidelines regarding the timeliness of care for children presenting with these acute pain crises. These evidence-based guidelines are infrequently followed, resulting in increased pain and hospitalizations. In additional to other barriers to following the guideline, structural racism has been proposed as a significant contributor and the New England Journal of Medicine recently called for the institution of SCD-specific pain management protocols to combat structural racism and reduce time to opioid administration. The investigators' long-term goal is to improve the care and health outcomes of children with acute painful vaso-occlusive crisis treated in the emergency department. The overall aim of the investigators is to test a care pathway using multifaceted implementation strategies to increase guideline adherent care for children in the emergency department with acute painful vaso-occlusive crisis.
What is being tested
- Care pathway (other)
Sponsor: Medical College of Wisconsin · Participants: 5,328 · Started: Sep 1, 2021
Contact the study team
- David Brousseau, MD, MS · Phone: (302) 651-4000
Official record on ClinicalTrials.gov — NCT05373771
Locations in the U.S.
| Wisconsin | Children's Wisconsin, Milwaukee |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.