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Healthy volunteer studies in Knoxville, TN

17 studies at sites in and around Knoxville accept healthy volunteers — people without the condition being studied. Many studies pay participants for their time and travel; the amount is set by each study, so ask the study team.

A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

RecruitingHealthy volunteers welcome
  • University of Tennessee Medical Center, Knoxville
Ages 55 and older · All sexes · Updated Sep 28, 2026 · NCT06112418

BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies

RecruitingPhase 3Healthy volunteers welcome
  • University of Tennessee Medical Center, Knoxville
1 Day – 49 Years · All sexes · Updated Sep 25, 2026 · NCT07160244

A Study on the Efficacy of a Vaccine Against Influenza in Adults ≥65 Years of Age

RecruitingPhase 3Healthy volunteers welcome
  • GSK Investigational Site, Knoxville
  • GSK Investigational Site, Knoxville
Ages 65 and older · All sexes · Updated Sep 18, 2026 · NCT07805707

Study to Assess Safety and Immunogenicity of an Egg-based H5N8 Influenza Vaccine at Multiple Dose Levels Adjuvanted With Matrix-M in Healthy Participants 18 Years of Age and Above.

RecruitingPhase 1/2Healthy volunteers welcome
  • Alliance for Multispecialty Research - Weisgarber Medical Park- Site Number : 8400002, Knoxville
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07779408

A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and Older

RecruitingPhase 3Healthy volunteers welcome
  • New Phase Research and Development, Knoxville
Ages 65 and older · All sexes · Updated Sep 9, 2026 · NCT07282665

AI-Based Personalized Exercise Prescription Through Mobile Health on Physical Activity and Health Outcomes in Older Adults: A Feasibility Study

RecruitingHealthy volunteers welcome
Ages 65 and older · All sexes · Updated Aug 20, 2026 · NCT07768670

Robotic Versus Open Ventral Hernia Repair

RecruitingHealthy volunteers welcome
  • University of Tennessee Medical Center, Knoxville, Knoxville
Ages 18 and older · All sexes · Updated Aug 14, 2026 · NCT05472987

A Phase 1 Study of 99mTc-p5+14 in Healthy Volunteers and Patients With AL or ATTR Systemic Amyloidosis

RecruitingPhase 1Healthy volunteers welcome
  • University of Tennessee Graduate School of Medicine, Knoxville
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT05951816

Pancreatic Cancer Early Detection Consortium

RecruitingObservational studyHealthy volunteers welcome
  • University of Tennessee Graduate School of Medicine, Knoxville
Ages 18 to 90 · All sexes · Updated Jul 22, 2026 · NCT04970056

A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)

RecruitingPhase 1/2Healthy volunteers welcome
  • Statcare Pulmonary Consultants, Knoxville
Ages 18 to 100 · All sexes · Updated Jul 21, 2026 · NCT06649110

EBT Fruit and Vegetable Prescription

RecruitingHealthy volunteers welcome
  • Cherokee Health Systems, Dameron Avenue Pedatrics, Knoxville
Ages 4 to 10 · All sexes · Updated Jun 9, 2026 · NCT05028205

Early Childhood Dietary Assessment Study

RecruitingHealthy volunteers welcome
  • Healthy Eating and Activity Lab, University of Tennessee, Knoxville
Ages 2 to 5 · All sexes · Updated Jun 8, 2026 · NCT07227272

Planning Together: A Couple-based, Multi-level Prenatal Contraceptive Education Program for Economically Marginalized Families

RecruitingHealthy volunteers welcome
  • University of Tennessee Graduate School of Medicine, Knoxville
Ages 18 and older · All sexes · Updated May 18, 2026 · NCT07214012

A First in Human Study of the Safety, Tolerability, and the Physiologically Based Pharmacokinetics of XFB19 in Healthy Adult Volunteers.

RecruitingPhase 1Healthy volunteers welcome
  • AMR Clinical, Knoxville
Ages 18 to 55 · All sexes · Updated May 1, 2026 · NCT05361733

A Study to Learn About a Vaccine Against E Coli in Healthy Adults

RecruitingPhase 1Healthy volunteers welcome
  • Alliance for Multispecialty Research, LLC, Knoxville
  • Alliance for Multispecialty Research, LLC, Knoxville
  • University Eye Specialists, P.C. (Ophthalmologist), Maryville · 14 mi away
Ages 18 to 64 · All sexes · Updated Apr 30, 2026 · NCT07122986

Safety and Immunogenicity Study of Revaccination With SCB-1019T in Healthy Adults

RecruitingPhase 1Healthy volunteers welcome
  • Knoxville, Knoxville
Ages 60 to 85 · All sexes · Updated May 14, 2025 · NCT06843317

The ME&MG Digital Solution for Autonomous Assessment of Myasthenia Gravis

RecruitingHealthy volunteers welcome
  • The University of Tennessee Medical Center, Knoxville
Ages 18 and older · All sexes · Updated Apr 11, 2025 · NCT05564936

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.