Home › Head and Neck Cancer › California
Head and Neck Cancer clinical trials in California
31 studies for Head and Neck Cancer are looking for participants at sites in California.
Cities in California
- Los Angeles10 studies
- San Francisco9 studies
- San Diego7 studies
- Baldwin Park7 studies
- Mountain View6 studies
- Sacramento5 studies
- Santa Rosa4 studies
- Orange3 studies
- Irvine3 studies
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
- University of San Diego Moores Cancer Center, La Jolla
- UCLA Jonsson Comprehensive Cancer Center, Los Angeles
- USC Norris Comprehensive Cancer Center, Los Angeles
RecruitingPhase 1/2
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
- Site #0107, La Jolla
- Site #0106, Los Angeles
- Site#0144, Sacramento
- and 2 more
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06788990Distance-Based Exercise to Preserve Function and Prevent Disability
- Kaiser Permanente Dublin, Dublin
- Kaiser Permanente-Fremont, Fremont
- Kaiser Permanente Fresno Orchard Plaza, Fresno
- and 10 more
Recruiting
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07059884A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
- City of Hope, Duarte
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06172478A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
- City of Hope National Medical Center, Duarte
- City of Hope at Irvine Lennar, Irvine
- Ronald Reagan UCLA Medical Center, Los Angeles
- and 3 more
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07090499A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors
- ALX Center 9, La Jolla
- ALX Center 11, Santa Monica
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07085091DESTINY-PANTUMOUR04
- Research Site, San Diego
RecruitingObservational study
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000Intratumoral N17350 in Advanced Solid Tumors
- The Angeles Clinic and Research Institute, Los Angeles
- UCLA - Jonsson Comprehensive Cancer Center, Los Angeles
- Scripps Clinic Torrey Pines - La Jolla, San Diego
- and 1 more
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07339176Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer
- Stanford University, Stanford
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT06736379A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors
- City of Hope, Duarte
- Hoag Memorial Hospital Presbyterian, Irvine
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07020117Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT
- University of California, San Francisco, San Francisco
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06633224Exercise and Nutritional Prehabilitation for Head and Neck Cancer Patients
- UC Davis Health, Sacramento
- UC Davis Medical Center, Sacramento
Recruiting
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06722508A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC
- Site 105 - START Los Angeles, Los Angeles
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07462377Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
- City of Hope, Duarte
- Los Angeles Cancer Network, Glendale
- California Research Institute, Los Angeles
- and 3 more
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT04198766Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial
- Chao Family Comprehensive Cancer Center, University of California Irvine, Orange
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 14, 2026 · NCT06580002Locally ablatiVe therApy in oLigO-pRogressive sOlid tUmorS (VALOROUS)
- University of California, Davis, Sacramento
Recruiting
Ages 18 and older · All sexes · Updated Jul 8, 2026 · NCT06103669First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors
- Ellison Clinic at Saint John's, Los Angeles
- UCSF Medical Center at Mission Bay, San Francisco
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT05768139Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers
- Stanford University School of Medicine, Stanford
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jul 1, 2026 · NCT00568490Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors
- Hoag Memorial Hospital Presbyterian, Newport Beach
- UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT06993844A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements
- St Joseph Heritage Healthcare, Santa Rosa
RecruitingPhase 1/2
Ages 12 and older · All sexes · Updated May 27, 2026 · NCT03093116A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma
- GSK Investigational Site, Los Angeles
- GSK Investigational Site, Solvang
- GSK Investigational Site, Stockton
- and 1 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated May 26, 2026 · NCT06256588Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial
- Chao Family Comprehensive Cancer Center, University of California Irvine, Orange
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Mar 3, 2026 · NCT07447050cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
- City of Hope, Duarte
RecruitingObservational studyHealthy volunteers welcome
Ages 40 and older · All sexes · Updated Jan 20, 2026 · NCT05366881Identification and Characterization of Novel Proteins and Genes in Head and Neck Cancer
- Stanford University School of Medicine, Stanford
RecruitingObservational study
Ages 18 and older · All sexes · Updated Dec 24, 2025 · NCT00230308Tumor-Informed ctDNA Testing for MRD Following Treatment of Squamous Cell Carcinoma
- University of California, San Francisco, San Francisco
RecruitingObservational study
Ages 18 and older · All sexes · Updated Dec 12, 2025 · NCT06606028VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma
- Providence Medical Foundation (site 209), Santa Rosa
RecruitingPhase 1/2
Ages 18 to 80 · All sexes · Updated Dec 11, 2025 · NCT03556228SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
- Massive Bio SYNERGY-AI site, Duarte
- Massive Bio SYNERGY-AI site, Irvine
- Massive Bio SYNERGY-AI site, La Jolla
- and 3 more
RecruitingObservational study
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors
- Cedars Sinai Medical Center, Los Angeles
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 24, 2025 · NCT05941507Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
- Moores Cancer Center UC San Diego Health, La Jolla
- Keck School of Medicine of USC, Los Angeles
- UCLA, Los Angeles
- and 1 more
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 15, 2025 · NCT04429542Prospective Data Registry and Quality of Life Assessment of Patients Undergoing Radiotherapy With the RefleXion Medical Radiotherapy System
- City Of Hope, Duarte
- Stanford Cancer Center, Palo Alto
RecruitingObservational study
All ages · All sexes · Updated Aug 15, 2025 · NCT05406167A Multicenter Cancer Biospecimen Collection Study
- Curebase, San Francisco
RecruitingObservational study
Ages 18 and older · All sexes · Updated Mar 12, 2025 · NCT04510129From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.