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Head and Neck Cancer clinical trials recruiting in the U.S.
157 studies for Head and Neck Cancer are recruiting participants at sites across the United States.
Head and neck cancer includes cancers of the mouth, nose, sinuses, salivary glands, throat, and lymph nodes. Read the different symptoms of each type.
Cities with the most studies
- Houston, TX30 studies
- New York City, NY23 studies
- Boston, MA23 studies
- Nashville, TN22 studies
- St. Louis, MO17 studies
- Pittsburgh, PA13 studies
- Dallas, TX13 studies
- Los Angeles, CA12 studies
- Chicago, IL12 studies
- Durham, NC11 studies
- Baltimore, MD11 studies
- Washington, DC11 studies
- Miami, FL10 studies
- San Antonio, TX10 studies
- Edison, NJ9 studies
- San Diego, CA9 studies
- Cleveland, OH9 studies
- San Francisco, CA9 studies
- Tampa, FL9 studies
- Philadelphia, PA9 studies
- Charleston, SC8 studies
- Portland, OR8 studies
- Columbus, OH8 studies
- New Haven, CT8 studies
- Rochester, MN7 studies
- Baldwin Park, CA7 studies
- Orlando, FL7 studies
- Aurora, CO6 studies
- Queens, NY6 studies
- Staten Island, NY6 studies
- New Rochelle, NY6 studies
- Mountain View, CA6 studies
- Cedar Rapids, IA6 studies
- Milwaukee, WI6 studies
- Arlington, VA6 studies
- Sacramento, CA5 studies
- Newark, NJ5 studies
- Birmingham, AL5 studies
- Seattle, WA5 studies
- Charlottesville, VA5 studies
By state
- Alabama5 studies
- Arizona4 studies
- Arkansas3 studies
- California33 studies
- Colorado10 studies
- Connecticut10 studies
- Delaware3 studies
- District of Columbia5 studies
- Florida25 studies
- Georgia5 studies
- Illinois13 studies
- Iowa6 studies
- Kansas7 studies
- Kentucky6 studies
- Louisiana4 studies
- Maryland17 studies
- Massachusetts25 studies
- Michigan11 studies
- Minnesota11 studies
- Missouri18 studies
- Nebraska5 studies
- New Jersey14 studies
- New Mexico4 studies
- New York32 studies
- North Carolina15 studies
- Ohio17 studies
- Oklahoma7 studies
- Oregon8 studies
- Pennsylvania23 studies
- Rhode Island4 studies
- South Carolina10 studies
- Tennessee25 studies
- Texas42 studies
- Utah6 studies
- Virginia15 studies
- Washington5 studies
- Wisconsin9 studies
Recently updated studies
Reflectance Confocal Microscopy of Oral Cancers in Vivo: a Preliminary Trial Comparing Intra-oral Imaging With Pathology
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT02507141Study Evaluating the Safety and Feasibility of Panitumumab-IRDye800 and [18F]NOTA-ABY-030 for Targeted Dual-Modality Imaging (TDMI) in Head and Neck Squamous Cell Carcinoma
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT07741643Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer
RecruitingPhase 1/2
Ages 18 to 120 · All sexes · Updated Nov 13, 2026 · NCT07667400Window Trial of Intratumoral (IT) Neoadjuvant Fluorescently Labelled Nivolumab (nivo800) in Head and Neck Squamous Cell Carcinoma (HNSCC)
RecruitingEarly phase 1
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07741565Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06627270Bevonescein for Improved Intraoperative Nerve Visualization to Improve Voice Outcomes in Thyroidectomy Patients
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07631650Self-Management for Head and Neck Lymphedema and Fibrosis [PROMISE Trial]
Recruiting
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT06125743A Study to Evaluate Lenti-HPV-07 Immunotherapy Against HPV+ Cervical or Oropharyngeal Cancer
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT06319963Biospecimen Procurement for Head and Neck Disorders
RecruitingObservational study
Ages 3 to 120 · All sexes · Updated Nov 9, 2026 · NCT03429036A Study of Neurocognitive Tests and Questionnaires for People With Head and Neck Cancer Who Are Undergoing Radiation Therapy
RecruitingObservational study
Ages 18 to 89 · All sexes · Updated Nov 6, 2026 · NCT05207098A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs at Minimal Risk and Primary Site Disease (SAVED)
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT07418034Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT04198766A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07090499Autologous CAR-T Cells Targeting CSPG4 in Relapsed/Refractory HNSCC
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT06096038cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
RecruitingObservational studyHealthy volunteers welcome
Ages 40 and older · All sexes · Updated Nov 4, 2026 · NCT05366881VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma
RecruitingPhase 1/2
Ages 18 to 80 · All sexes · Updated Nov 4, 2026 · NCT03556228Distance-Based Exercise to Preserve Function and Prevent Disability
Recruiting
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07059884Feasibility of Cough Skill Training in Individuals With Head and Neck Cancer
Recruiting
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07756684Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers
RecruitingObservational study
Ages 21 to 90 · All sexes · Updated Nov 3, 2026 · NCT00900419An Imaging Agent (Pafolacianine) for Identifying Lesions in Pediatric Patients With Primary or Metastatic Solid Tumors
RecruitingPhase 3
6 Months – 17 Years · All sexes · Updated Oct 30, 2026 · NCT06915727FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Oct 29, 2026 · NCT06788990SumMET: Study of [225Ac]Ac-FL-261 in Participants With Solid Tumors Overexpressing c-MET
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 29, 2026 · NCT07873450Safety and Tolerability of Metformin and Naproxen for Cancer Prevention in Fanconi Anemia
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT07901959Ordastobart (INBRX-106) Add-on to Pembrolizumab in 1L HPV+ PD-L1+ R/M OPSCC (HexAgon-HN)
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT06295731Lead-212 PSV359 Therapy for Patients With Solid Tumors
RecruitingPhase 1/2
Ages 18 to 90 · All sexes · Updated Oct 28, 2026 · NCT06710756From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.