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Head and Neck Cancer clinical trials recruiting in the U.S.
145 studies for Head and Neck Cancer are recruiting participants at sites across the United States.
Head and neck cancer includes cancers of the mouth, nose, sinuses, salivary glands, throat, and lymph nodes. Read the different symptoms of each type.
Cities with the most studies
- Houston, TX30 studies
- Boston, MA22 studies
- New York City, NY21 studies
- Nashville, TN21 studies
- St. Louis, MO14 studies
- Dallas, TX12 studies
- Pittsburgh, PA11 studies
- Miami, FL11 studies
- Durham, NC10 studies
- Washington, DC10 studies
- Baltimore, MD10 studies
- San Antonio, TX10 studies
- Los Angeles, CA10 studies
- Tampa, FL9 studies
- Chicago, IL9 studies
- Edison, NJ9 studies
- Philadelphia, PA9 studies
- Cleveland, OH9 studies
- Charleston, SC8 studies
- Rochester, MN8 studies
- New Haven, CT8 studies
- San Francisco, CA8 studies
- Portland, OR7 studies
- Columbus, OH7 studies
- Baldwin Park, CA7 studies
- Aurora, CO6 studies
- New Rochelle, NY6 studies
- Queens, NY6 studies
- Staten Island, NY6 studies
- Orlando, FL6 studies
- Mountain View, CA6 studies
- San Diego, CA6 studies
- Salt Lake City, UT5 studies
- Arlington, VA5 studies
- Detroit, MI5 studies
- Milwaukee, WI5 studies
- Atlanta, GA5 studies
- Memphis, TN5 studies
- Seattle, WA5 studies
- Cedar Rapids, IA5 studies
By state
- Alabama5 studies
- Arizona4 studies
- Arkansas3 studies
- California30 studies
- Colorado9 studies
- Connecticut10 studies
- District of Columbia5 studies
- Florida25 studies
- Georgia7 studies
- Illinois10 studies
- Iowa5 studies
- Kansas7 studies
- Kentucky5 studies
- Louisiana3 studies
- Maryland15 studies
- Massachusetts24 studies
- Michigan10 studies
- Minnesota10 studies
- Missouri15 studies
- Nebraska5 studies
- New Jersey12 studies
- New Mexico3 studies
- New York29 studies
- North Carolina14 studies
- Ohio17 studies
- Oklahoma6 studies
- Oregon7 studies
- Pennsylvania20 studies
- Rhode Island4 studies
- South Carolina10 studies
- Tennessee23 studies
- Texas42 studies
- Utah7 studies
- Virginia11 studies
- Washington6 studies
- Wisconsin8 studies
Recently updated studies
NIDCD Otolaryngology Clinical Protocol Biospecimen Bank
RecruitingObservational study
Ages 3 to 99 · All sexes · Updated Sep 28, 2026 · NCT06303180Biospecimen Procurement for Head and Neck Disorders
RecruitingObservational study
Ages 3 to 120 · All sexes · Updated Sep 28, 2026 · NCT03429036Pilot Study of Management of Facial Paralysis in the Oncologic Patient: Nerve Transfer Techniques to Improve Facial Function and Quality of Life
Recruiting
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06667427DESTINY-PANTUMOUR04
RecruitingObservational study
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06172478Intratumoral N17350 in Advanced Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07339176Continuous Monitoring of Microvascular Anastomoses: An Observational Trial
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07823283Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT06736379A Pilot Study of Ultra-High Dose Rate (ConformalFLASH®), for Reirradiation of Carcinoma of the Head and Neck
Recruiting
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07644585Postoperative Radiotherapy for Intermediate- and High-risk Patients With HNSCC Greater Than 6 Weeks After Surgery
Recruiting
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT06607406A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07020117Autologous CAR-T Cells Targeting CSPG4 in Relapsed/Refractory HNSCC
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT06096038Effects of Infusion Timing on Treatment Response in Solid Tumors
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07630168Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06633224The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
RecruitingPhase 1/2
Ages 12 and older · All sexes · Updated Sep 15, 2026 · NCT04585750Exercise and Nutritional Prehabilitation for Head and Neck Cancer Patients
Recruiting
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06722508First in Human Study of TUB-030 in Patients With Advanced Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06657222A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07462377A Study Evaluating Ficerafusp Alfa (BCA101) QW in Combination With Pembrolizumab vs Alternative Ficerafusp Alfa Dosing in 1L R or M HNSCC
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT07807163Building a Renewed ImaGe After Head & Neck Cancer Treatment (BRIGHT) Multi-Site RCT
Recruiting
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT05442957A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT07090499Self-Management for Head and Neck Lymphedema and Fibrosis [PROMISE Trial]
Recruiting
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT06125743Atorvastatin to Reduce Cisplatin-Induced Hearing Loss Among Individuals With Head and Neck Cancer
RecruitingPhase 2
Ages 18 to 100 · All sexes · Updated Sep 2, 2026 · NCT04915183Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women
RecruitingObservational study
Ages 18 to 50 · Women · Updated Sep 2, 2026 · NCT06904365Prehabilitation Protocol for Head and Neck Cancer Patients
RecruitingHealthy volunteers welcome
Ages 18 to 80 · All sexes · Updated Sep 1, 2026 · NCT07318220From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.