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Lung Cancer clinical trials in Oklahoma City, OK

19 studies for Lung Cancer are looking for participants at sites in and around Oklahoma City (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

The Vanguard Study: Testing a New Way to Screen for Cancer

RecruitingHealthy volunteers welcome
  • University of Oklahoma Health Sciences Center, Oklahoma City
Ages 45 to 75 · All sexes · Updated Oct 5, 2026 · NCT06995898

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

RecruitingPhase 3
  • Mercy Hospital Oklahoma City, Oklahoma City
Ages 70 and older · All sexes · Updated Oct 5, 2026 · NCT06096844

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

RecruitingPhase 3
  • University of Oklahoma Health Sciences Center, Oklahoma City
  • Mercy Hospital Oklahoma City, Oklahoma City
  • Integris Cancer Institute of Oklahoma, Oklahoma City
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT04267848

Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

RecruitingPhase 3
  • University of Oklahoma Health Sciences Center, Oklahoma City
  • Integris Cancer Institute of Oklahoma, Oklahoma City
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT04181060

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • University of Oklahoma, Oklahoma City
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Mercy Hospital Oklahoma City, Oklahoma City
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

RecruitingPhase 3
  • University of Oklahoma Health Sciences Center, Oklahoma City
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06498635

Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer

RecruitingPhase 2/3
  • INTEGRIS Cancer Institute of Oklahoma, Oklahoma City
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06712316

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

RecruitingPhase 1/2
  • University of Oklahoma, Oklahoma City
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551

Identification and Validation of Blood-Based Biomarkers for Early Detection of Asymptomatic Lung Cancer in High-Risk Heavy Smokers

RecruitingObservational studyHealthy volunteers welcome
  • Site 101, Oklahoma City
Ages 30 to 80 · All sexes · Updated Sep 11, 2026 · NCT06816121

Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

RecruitingPhase 3
  • University of Oklahoma Health Sciences Center, Oklahoma City
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05624996

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

RecruitingPhase 3
  • University of Oklahoma Health Sciences Center, Oklahoma City
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT06500481

Study of XmAb®819 in Subjects With Advanced Clear Cell Renal Cell Carcinoma

RecruitingPhase 1
  • Xencor Investigative Site, Oklahoma City
Ages 18 and older · All sexes · Updated Aug 3, 2026 · NCT05433142

A Study of Peluntamig (PT217) in Patients With Neuroendocrine Carcinomas Expressing DLL3 (the SKYBRIDGE Study)

RecruitingPhase 1/2
  • Sarah Cannon Research Institute University of Oklahoma, Oklahoma City
Ages 18 and older · All sexes · Updated Jul 15, 2026 · NCT05652686

Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)

RecruitingPhase 2
  • University of Oklahoma Health Sciences Center, Oklahoma City
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT05642572

Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

RecruitingPhase 2/3
  • University of Oklahoma Health Sciences Center, Oklahoma City
  • Integris Southwest Medical Center, Oklahoma City
  • Mercy Hospital Oklahoma City, Oklahoma City
Ages 18 and older · All sexes · Updated May 5, 2026 · NCT06616584

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

RecruitingPhase 2
  • University of Oklahoma Health Sciences Center, Oklahoma City
18 Minutes · All sexes · Updated May 5, 2026 · NCT06031688

Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening

RecruitingObservational study
  • Hightower Clinical, Oklahoma City
Ages 50 and older · All sexes · Updated Aug 5, 2025 · NCT06122077

About Lung Cancer

Lung cancer forms in tissues of the lung, usually in the cells that line the air passages. It is the leading cause of cancer death in both men and women.

More about Lung Cancer on MedlinePlus

Lung Cancer trials in other cities

Other studies in Oklahoma City

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.