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The Vanguard Study: Testing a New Way to Screen for Cancer

피험자 모집 중건강한 지원자 환영
  • Louis Stokes Cleveland VA Medical Center, Cleveland
45세 ~ 75세 · 모든 성별 · 2026. 10. 5. 업데이트됨 · NCT06995898

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

피험자 모집 중1/2상
  • The Cleveland Clinic Taussig Cancer Center, Cleveland
12세 이상 · 모든 성별 · 2026. 10. 2. 업데이트됨 · NCT04585750

A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

피험자 모집 중2상
  • Cleveland Clinic - Oncology Department, Cleveland
18세 이상 · 모든 성별 · 2026. 10. 2. 업데이트됨 · NCT06760819

Study of AVZO-021 in Patients With Advanced Solid Tumors

피험자 모집 중1/2상
  • Avenzo Therapeutics Recruiting Site, Cleveland
18세 이상 · 모든 성별 · 2026. 9. 28. 업데이트됨 · NCT05867251

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

피험자 모집 중1/2상
  • Cleveland Clinic, Cleveland
18세 이상 · 모든 성별 · 2026. 9. 23. 업데이트됨 · NCT06618287

Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer

피험자 모집 중
  • Cleveland Clinic, Cleveland
18세 이상 · 모든 성별 · 2026. 9. 23. 업데이트됨 · NCT07214532

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

피험자 모집 중3상
  • University Hospitals Cleveland Medical Center, Cleveland
  • Fairview Hospital, Cleveland
  • Cleveland Clinic - Hillcrest Hospital, Mayfield Heights · 12마일 거리
18세 이상 · 모든 성별 · 2026. 9. 22. 업데이트됨 · NCT07174336

A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

피험자 모집 중1/2상
  • UH Cleveland Medical Center, Cleveland
18세 이상 · 모든 성별 · 2026. 9. 17. 업데이트됨 · NCT07109726

Study to Investigate Efficacy of a Novel Probiotic on the Bacteriome and Mycobiome of Breast Cancer

피험자 모집 중
  • Cleveland Clinic Taussig Cancer institute, Case Comprehensive Cancer Center, Cleveland
18세 ~ 65세 · 여성 · 2026. 9. 15. 업데이트됨 · NCT04362826

A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

피험자 모집 중3상
  • MetroHealth, Cleveland
  • Cleveland Clinic, Cleveland
18세 이상 · 모든 성별 · 2026. 9. 15. 업데이트됨 · NCT06492616

A Phase 1/1b Study of IAM1363 in HER2 Cancers

피험자 모집 중1상
  • University Hospital Cleveland Medical Center, Cleveland
  • Cleveland Clinic, Cleveland
18세 이상 · 모든 성별 · 2026. 9. 9. 업데이트됨 · NCT06253871

A Trial to Evaluate Ovarian Suppression Following Subcutaneous ZOLADEX 10.8 mg in Premenopausal Women With Early-stage and Advanced HR+ Breast Cancer

피험자 모집 중1상
  • Cleveland Clinic Foundation, Cleveland
18세 ~ 55세 · 여성 · 2026. 9. 9. 업데이트됨 · NCT07310420

A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

피험자 모집 중3상
  • Fairview Hospital, Cleveland
  • Cleveland Clinic Foundation, Cleveland
  • Hillcrest Hospital, Mayfield Heights · 12마일 거리
18세 이상 · 모든 성별 · 2026. 9. 3. 업데이트됨 · NCT06790693

Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.

피험자 모집 중3상
  • Cleveland Clinic, Cleveland
18세 이상 · 모든 성별 · 2026. 9. 2. 업데이트됨 · NCT06072612

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

피험자 모집 중3상
  • Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
  • Cleveland Clinic Foundation, Cleveland
  • South Pointe Hospital, Warrensville Heights · 9마일 거리
  • 외 1개
18세 ~ 60세 · 여성 · 2026. 9. 2. 업데이트됨 · NCT05879926

A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors

피험자 모집 중1상
  • Cleveland Clinic, Cleveland
18세 이상 · 모든 성별 · 2026. 8. 28. 업데이트됨 · NCT07029399

A Phase 1 Study of LNCB74 in Advanced Solid Tumors

피험자 모집 중1상
  • Cleveland Clinic Taussig Cancer Institute, Cleveland
18세 이상 · 모든 성별 · 2026. 8. 21. 업데이트됨 · NCT06774963

Repeat Breast Conserving Surgery Followed by Daily Partial Breast Irradiation in Ipsilateral Breast

피험자 모집 중2상
  • University Hospitals Cleveland Medical Center, Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland
  • Cleveland Clinic Taussig Cancer Center, Case Comprehensive Cancer Center, Cleveland
19세 이상 · 모든 성별 · 2026. 8. 6. 업데이트됨 · NCT06129747

Finding the Best Tamoxifen Dose for Breast Cancer Risk Reduction in Premenopausal Women, RENAISSANCE Trial

피험자 모집 중2상
  • Case Western Reserve University, Cleveland
18세 ~ 55세 · 여성 · 2026. 7. 27. 업데이트됨 · NCT06184750

TeleHealth Resistance Exercise Intervention to Preserve Dose Intensity and Vitality in Elder Breast Cancer Patients

피험자 모집 중
  • Case Western Reserve University/University Hospitals Cleveland, Cleveland
65세 이상 · 여성 · 2026. 7. 17. 업데이트됨 · NCT05535192

Study of Ribociclib Administered Concurrently With Postoperative Radiation Therapy in Patients With High-Risk, HR+/HER2- Breast Cancer

피험자 모집 중1상
  • UHCMC Seidman Cancer Center, Cleveland
18세 이상 · 여성 · 2026. 7. 15. 업데이트됨 · NCT05996107

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

피험자 모집 중1/2상
  • UH Cleveland Medical Center, Cleveland
18세 이상 · 모든 성별 · 2026. 7. 7. 업데이트됨 · NCT05768139

Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

피험자 모집 중3상
  • University Hospitals Seidman Cancer Center, Cleveland
18세 이상 · 모든 성별 · 2026. 6. 22. 업데이트됨 · NCT05696626

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

피험자 모집 중2상
  • Cleveland Clinic, Cleveland
18세 이상 · 모든 성별 · 2026. 5. 6. 업데이트됨 · NCT01042379

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

피험자 모집 중3상
  • Case Western Reserve University, Cleveland
  • MetroHealth Medical Center, Cleveland
  • Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
  • 외 3개
50세 ~ 70세 · 모든 성별 · 2026. 4. 23. 업데이트됨 · NCT04852887

Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/Her2- Breast Cancer

피험자 모집 중1/2상
  • Cleveland Clinic, Cleveland
18세 이상 · 모든 성별 · 2026. 4. 22. 업데이트됨 · NCT05455619

Real World Treatment Experience of Patients With Breast, Lung, Ovarian, Multiple Myeloma, or Acute Myelogenous Leukemia Using Remote Symptom Monitoring

피험자 모집 중관찰 연구
  • University Hospitals Seidman Cancer Center, Cleveland
18세 이상 · 모든 성별 · 2026. 2. 23. 업데이트됨 · NCT05974150

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

피험자 모집 중관찰 연구건강한 지원자 환영
  • Cleveland Clinic, Cleveland
40세 이상 · 모든 성별 · 2026. 1. 20. 업데이트됨 · NCT05366881

EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)

피험자 모집 중관찰 연구
  • Cleveland Clinic Main Campus, Cleveland
18세 이상 · 모든 성별 · 2026. 1. 20. 업데이트됨 · NCT06401421

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

피험자 모집 중관찰 연구
  • Massive Bio SYNERGY-AI site, Mayfield Heights · 12마일 거리
전 연령 · 모든 성별 · 2025. 10. 28. 업데이트됨 · NCT03452774

The Cancer of the Pancreas Screening-5 CAPS5)Study

피험자 모집 중3상
  • Case Comprehensive Cancer Center, Case Western Medical Reserve, Cleveland
18세 이상 · 모든 성별 · 2025. 10. 9. 업데이트됨 · NCT02000089

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

피험자 모집 중3상
  • Case Western Reserve University, Cleveland
  • Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
  • Cleveland Clinic Foundation, Cleveland
  • 외 3개
18세 이상 · 모든 성별 · 2025. 10. 8. 업데이트됨 · NCT03418961

A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors

피험자 모집 중1상
  • Exelixis Clinical Site #7, Cleveland
18세 이상 · 모든 성별 · 2025. 9. 5. 업데이트됨 · NCT05932862

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