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Breast Cancer clinical trials in California
179 studies for Breast Cancer are looking for participants at sites in California.
Cities in California
- Los Angeles72 studies
- Baldwin Park45 studies
- San Francisco43 studies
- San Diego41 studies
- Santa Monica27 studies
- Mountain View25 studies
- Irvine23 studies
- Sacramento20 studies
- Newport Beach16 studies
- Orange14 studies
- Santa Rosa11 studies
- Vallejo10 studies
- Fullerton9 studies
- Burbank9 studies
- Long Beach9 studies
- Concord9 studies
- Torrance9 studies
- Westminster7 studies
- Oakland7 studies
- Santa Clara7 studies
- Roseville7 studies
- Richmond7 studies
- Stockton7 studies
- Santa Barbara6 studies
- Indio6 studies
- Fresno6 studies
- San Jose6 studies
- Redwood City6 studies
- Fremont6 studies
- Pleasanton6 studies
- Huntington Beach6 studies
- Modesto5 studies
- Santa Maria5 studies
- Anaheim5 studies
- Whittier4 studies
- Glendale4 studies
- Daly City4 studies
- Vacaville4 studies
- Arden-Arcade4 studies
- San Leandro4 studies
- Elk Grove4 studies
- Antioch4 studies
- Riverside4 studies
- San Bernardino4 studies
- Alhambra4 studies
- San Marcos4 studies
- Pasadena4 studies
- Bakersfield4 studies
- Norwalk3 studies
- Bellflower3 studies
- Ontario3 studies
- Berkeley3 studies
- Santa Clarita3 studies
- Sunnyvale3 studies
- Upland3 studies
- San Mateo3 studies
- Salinas3 studies
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
- University of San Diego Moores Cancer Center, La Jolla
- UCLA Jonsson Comprehensive Cancer Center, Los Angeles
- USC Norris Comprehensive Cancer Center, Los Angeles
RecruitingPhase 1/2
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750Distance-Based Exercise to Preserve Function and Prevent Disability
- Kaiser Permanente Dublin, Dublin
- Kaiser Permanente-Fremont, Fremont
- Kaiser Permanente Fresno Orchard Plaza, Fresno
- and 10 more
Recruiting
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07059884Phase IIIb Study of Ribociclib + ET in Early Breast Cancer
- Onco Inst of Hope and Innovation, Cerritos
- City of Hope National Medical, Duarte
- Providence Medical Foundation, Fullerton
- and 7 more
RecruitingPhase 3
Ages 18 to 100 · All sexes · Updated Oct 2, 2026 · NCT05827081Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
- Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande
- PCR Oncology, Arroyo Grande
- AIS Cancer Center at San Joaquin Community Hospital, Bakersfield
- and 20 more
RecruitingObservational studyHealthy volunteers welcome
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
- City of Hope - Duarte Cancer Center, Duarte
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06760819A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
- City of Hope, Duarte
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06172478A Study of Patritumab Deruxtecan (HER3-DXd) in Combination With Trastuzumab Deruxtecan (T-DXd) in Participants With HR-Positive, HER2-Low or HER2-Ultralow Unresectable or Metastatic Breast Cancer
- Cedars-Sinai Medical Center - Samuel Oschin Comprehensive Cancer Institute, Los Angeles
- Stanford Medicine Cancer Center, Stanford
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07701941A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer
- Oncology Institute, Long Beach
- Cancer & Blood Research Center, Los Alamitos
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07102381Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors
- City of Hope Comprehensive Cancer Center, Duarte
- University of California Los Angeles, Los Angeles
- University of California San Diego Moores Cancer Center, San Diego
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06625775A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer
- Beverly Hills Cancer Center, Beverly Hills
- MemorialCare Orange Coast Medical Center, Fountain Valley
- City of Hope at Orange County Lennar Foundation Cancer Center, Irvine
- and 3 more
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06369285Abemaciclib and Endocrine Therapy in Older Patients With Breast Cancer.
- City of Hope Medical Center, Duarte
- City of Hope at Irvine Lennar, Irvine
- City of Hope at Long Beach Elm, Long Beach
- and 1 more
RecruitingPhase 2
Ages 70 and older · All sexes · Updated Oct 1, 2026 · NCT04305834Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
- The Oncology Institute of Hope and Innovation, Cerritos
- Ellison Medical Institute, Los Angeles
- Valkyrie Clinical Trials, Los Angeles
- and 3 more
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06324357Conventionally Fractionated vs. Hypofractionated Comprehensive Nodal Irradiation for Breast Cancer Using Pencil Beam Scanning Proton Therapy
- California Protons Cancer Therapy Center, San Diego
RecruitingPhase 3
Ages 19 and older · Women · Updated Sep 29, 2026 · NCT05856773A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation
- Research Site, Duarte
- Research Site, Los Angeles
- Research Site, Newport Beach
- and 1 more
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT05877599Phase II Protocol of Proton Therapy for Partial Breast Irradiation in Early Stage Breast Cancer
- California Protons Cancer Therapy Center, San Diego
RecruitingPhase 2
Ages 50 and older · Women · Updated Sep 29, 2026 · NCT01766297IKS014 in Advanced Solid Tumors That Express HER2
- Hoag Memorial Hospital Presbyterian, Newport Beach
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT05872295A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)
- Los Angeles Hematology Oncology Medical Group ( Site 0026), Los Angeles
- Hoag Memorial Hospital Presbyterian ( Site 0025), Newport Beach
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07060807A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer
- Los Angeles Cancer Network, Los Angeles
- Community Clinical Trials, Orange
RecruitingPhase 2
Ages 18 and older · Women · Updated Sep 25, 2026 · NCT07054190A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)
- Roy and Patricia Disney Family Cancer Center ( Site 0055), Burbank
- Community Cancer Institute ( Site 0100), Clovis
- Providence Medical Foundation ( Site 0080), Fullerton
- and 4 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06966700A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)
- Providence Medical Foundation-Oncology ( Site 0020), Fullerton
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06312176The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study
- Providence Medical Foundation, Eureka
- Providence Medical Foundation, Santa Rosa
RecruitingPhase 3
Ages 60 and older · All sexes · Updated Sep 25, 2026 · NCT06377852A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)
- Research Site, Fountain Valley
- Research Site, Glendale
- Research Site, Sacramento
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06103864ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer
- City of Hope, Duarte
- UC San Diego Moores Cancer Center, La Jolla
- UC Irvine Health - Chao Family Comprehensive Cancer Center, Orange
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07007559A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors
- Kivu Trial Site, Santa Monica
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT07229313A Study to Compare the Steady-State Bioavailability of Injectable Letrozole SIE and Oral Letrozole in Post-Menopausal Women With Hormone Receptor Positive Early Breast Cancer
- Precision NextGen Oncology and Research Center (Investigational Site number USA-001), Beverly Hills
RecruitingPhase 1
Ages 18 to 80 · Women · Updated Sep 23, 2026 · NCT07401381Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer
- Clinical Trial Site, Beverly Hills
- Clinical Trial Site, La Jolla
- Clinical Trial Site, Los Alamitos
- and 8 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07085767Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer
- Marin Cancer Care, Greenbrae
- Loma Linda University, Loma Linda
- Cancer and Blood Research Center, Los Alamitos
- and 3 more
Recruiting
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07214532A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
- Community Cancer Institute, Clovis
- City of Hope, Duarte
- Epic Care - Emeryville, Emeryville
- and 19 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07174336A Study of LY4257496 in Participants With Cancer (OMNIRAY)
- City of Hope, Duarte
- University of California, Los Angeles (UCLA), Santa Monica
- Stanford University Medical Center, Stanford
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07114601A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer
- City of Hope, Duarte
- City of Hope Orange County Lennar Foundation Cancer Center, Irvine
- USC/Norris Comprehensive Cancer Center, Los Angeles
- and 1 more
RecruitingPhase 2
Ages 18 and older · Women · Updated Sep 22, 2026 · NCT07287098A Study of LY4337713 in Participants With FAP-Positive Solid Tumors
- Hoag Memorial Hospital Presbyterian, Newport Beach
- Stanford University Medical Center, Stanford
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213791A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer
- Disney Family Cancer Center, Burbank
- City of Hope, Corona
- City of Hope Comprehensive Cancer Center, Duarte
- and 2 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05894239Women Informed to Screen Depending on Measures of Risk (Wisdom Study)
- University of California Irvine, Irvine
- University of California Los Angeles, Los Angeles
- University of California Davis, Sacramento
- and 2 more
RecruitingHealthy volunteers welcome
Ages 30 to 74 · Women · Updated Sep 21, 2026 · NCT02620852Pulsed Electric Field Ablation for Metastatic Breast Cancer
- University of California San Francisco, San Francisco
Recruiting
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07487844ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer
- University Of California - San Diego Moores Cancer Center, La Jolla
- Cancer and Blood Specialty Clinic (CBSC), Los Alamitos
- Cedar Sinai - Samuel Oschin Cancer Center, Los Angeles
- and 4 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07173751A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations
- City of Hope, Duarte
- City of Hope, Irvine, Irvine
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07109726A Clinical Study to Find the Optimal Dose of an Investigational Treatment Called BNT323 When Used in Combination With Another Investigational Treatment, BNT327, and to Test if That Combination Treatment is Safe and Beneficial for Patients With Advanced Breast Cancer
- Beverly Hills Cancer Center, Beverly Hills
- Hoag Memorial Hospital Presbyterian, Newport Beach
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT06827236ATUSA Ultrasound Diagnostic Imaging for Breast Lesions Evaluation (AUDIBLE) - iSono Health
- UC Davis, Sacramento
RecruitingObservational study
Ages 18 to 94 · Women · Updated Sep 17, 2026 · NCT07505797A Study of Breast Cancer Risk Factors and Outcomes of People in Florida
- University of California, Los Angeles (Specimen Analysis only), Los Angeles
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT06780176A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
- UCSF Cancer Center Berkeley, Berkeley
- Cedars-Sinai Cancer Beverly Hills, Beverly Hills
- City of Hope National Medical Center, Duarte
- and 19 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06492616From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.