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Breast Cancer clinical trials in Orange, CA

14 studies for Breast Cancer are looking for participants at sites in and around Orange (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

RecruitingPhase 3
  • UC Irvine Medical Center, Orange
Ages 18 to 100 · All sexes · Updated Oct 2, 2026 · NCT05827081

A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer

RecruitingPhase 2
  • Community Clinical Trials, Orange
Ages 18 and older · Women · Updated Sep 25, 2026 · NCT07054190

ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer

RecruitingPhase 2
  • UC Irvine Health - Chao Family Comprehensive Cancer Center, Orange
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07007559

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

RecruitingPhase 3
  • University of California, Irvine (UCI) Health - UC Irvine Medical Center, Orange
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07174336

A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

RecruitingPhase 3
  • UC Irvine Health, Chao Family Comprehensive Cancer Center, Orange
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06492616

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Ages 18 to 50 · All sexes · Updated Aug 4, 2026 · NCT06748222

Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

RecruitingPhase 2
  • Chao Family Comprehensive Cancer Center, University of California Irvine, Orange
Ages 18 and older · All sexes · Updated Jul 14, 2026 · NCT06580002

A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors

RecruitingPhase 1/2
  • UC Irvine Health-Chao Family Comprehensive Cancer Center, Orange
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05377996

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

RecruitingPhase 3
  • Saint Joseph Hospital - Orange, Orange
  • UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Ages 50 to 70 · All sexes · Updated Apr 23, 2026 · NCT04852887

Anastrazole, Fulvestrant & Abemaciclib for HR+HER2- Metastatic Breast Cancer

RecruitingPhase 2
  • Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange
Ages 18 and older · All sexes · Updated Mar 11, 2026 · NCT05524584

Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial

RecruitingPhase 2
  • Chao Family Comprehensive Cancer Center, University of California Irvine, Orange
Ages 18 and older · All sexes · Updated Mar 3, 2026 · NCT07447050

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Orange
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

About Breast Cancer

Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. These extra cells can form a mass called a tumor.

More about Breast Cancer on MedlinePlus

Breast Cancer trials in other cities

Other studies in Orange

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.