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Liver Cancer (Hepatocellular Carcinoma) clinical trials in California
54 studies for Liver Cancer (Hepatocellular Carcinoma) are looking for participants at sites in California.
Cities in California
- Los Angeles19 studies
- San Francisco14 studies
- Orange14 studies
- Mountain View10 studies
- Baldwin Park9 studies
- Santa Monica8 studies
- San Diego8 studies
- Irvine6 studies
- Sacramento4 studies
The Vanguard Study: Testing a New Way to Screen for Cancer
- Kaiser Permanente-Division of Research, Pleasanton
RecruitingHealthy volunteers welcome
Ages 45 to 75 · All sexes · Updated Oct 5, 2026 · NCT06995898A Study of ZW251 in Participants With Advanced Solid Tumors
- UCSF Comprehensive Cancer Center, San Francisco
- University of California Los Angeles - Cancer Care - Santa Monica (UCLA), Santa Monica
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT07164313Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
- Exelixis Clinical Site #59, Santa Barbara
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05176483Study of the Theranostic Pair RYZ811 (Diagnostic) and RYZ801 (Therapeutic) to Identify and Treat Subjects With GPC3+ (Glypican-3) Unresectable HCC
- Research Facility, Orange
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06726161Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.
- Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
- UCI Health - Irvine Infusion Pharmacy ACC, Irvine
- UCI Health - Irvine, Irvine
- and 8 more
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07227012National Liver Cancer Screening Trial
- University of Southern California, Los Angeles
- Stanford University, Redwood City
- Kaiser Permanente, Roseville
- and 1 more
RecruitingPhase 4
Ages 18 to 85 · All sexes · Updated Sep 25, 2026 · NCT06084234A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With Ipilimumab in Participants With First-Line Advanced or Unresectable Hepatocellular Carcinoma (HCC) (ROSETTA HCC-206)
- City Of Hope, Duarte
- Local Institution - 0070, Los Angeles
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07291076Safety and Preliminary Anti-Tumor Activity of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway Aberrations
- USC Norris Comprehensive Cancer Center, Los Angeles
- UCSF Medical Center at Mount Zion, San Francisco
- Stanford Cancer Institute, Stanford
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT06915753Visugromab, Nivolumab and Lenvatinib Compared to Double Placebo and Lenvatinib in Unresectable or Metastatic Hepatocellular Carcinoma Post Anti-PD-(L)1 Failure
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
- USC Norris Comprehensive Cancer Center, Los Angeles
- UC Irvine Health. Chao Family Comprehensive Cancer Center, Orange
RecruitingPhase 2
Ages 18 to 100 · All sexes · Updated Sep 23, 2026 · NCT07219459A Phase 1/2 Study of BGB-B2033, Alone or in Combination With Tislelizumab With or Without Bevacizumab, in Participants With Advanced or Metastatic Solid Tumors
- City of Hope National Medical Center, Duarte
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT06427941Real-world Evaluation of the HistoSonics Edison System for Treatment of Liver Tumors Across Multidisciplinary Users (BOOMBOX: Master Study)
- Providence St. Jude, Fullerton
- Cedars-Sinai Medical Center, Los Angeles
- Mission Hospital, Mission Viejo
- and 3 more
RecruitingObservational study
Ages 22 and older · All sexes · Updated Sep 11, 2026 · NCT06486454GPC3-Targeted T-Cell Therapy (ECT204) in Adults With Advanced HCC
- City of Hope, Duarte
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT04864054Testing the Addition of an Anti-cancer Drug, Sapanisertib, to the Usual Chemotherapy Treatment (Cabozantinib) in Metastatic Liver Cell Cancer With a Change in Genes for the Protein β-Catenin, The SAPHIRE Trial
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
- UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06811116Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma
- Research Site, Los Angeles
- Research Site, Palo Alto
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06921785Pilot Comparing ctDNA IDV vs. SPV Sample in Pts Undergoing Biopsies for Hepatobiliary and Pancreatic Cancers
- Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange
Recruiting
Ages 18 and older · All sexes · Updated Aug 31, 2026 · NCT05497531Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma
- University of Southern California, Los Angeles
- Cedars-Sanai Medical Center - Samuel Oschin Comprehensive Cancer, Los Angeles
- Cedars-Sanai Medical Center, Los Angeles
- and 1 more
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT06582017Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
- Children's Hospital Los Angeles, Los Angeles
- Children's Hospital of Orange County, Orange
- UCSF Medical Center-Mission Bay, San Francisco
RecruitingPhase 1/2
12 Months – 30 Years · All sexes · Updated Aug 25, 2026 · NCT04851119Patient-Derived Xenografts to Reduce Cancer Health Disparities
- UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
- University of California Davis Comprehensive Cancer Center, Sacramento
RecruitingObservational study
Ages 21 to 100 · All sexes · Updated Aug 20, 2026 · NCT04410302A First-in-human Study to Learn About the Safety of BAY 3547926 and How Well it Works in Participants With Advanced Liver Cancer
- Duarte, Duarte
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT06764316FOG-001 in Locally Advanced or Metastatic Solid Tumors
- University of California, Los Angeles (UCLA), Los Angeles
- Stanford Cancer Institute, Stanford University, Palo Alto
- University of California San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco
- and 1 more
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05919264Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients With Advanced Liver Cancer, HELIO-RT Trial
- Alta Bates Summit Medical Center-Herrick Campus, Berkeley
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park
- Palo Alto Medical Foundation-Fremont, Fremont
- and 11 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT07166406Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers
- University of California, San Francisco, San Francisco
- John Muir Medical Center-Walnut Creek, Walnut Creek
Recruiting
Ages 18 and older · All sexes · Updated Aug 14, 2026 · NCT04221893First in Human Study to Evaluate AZD9793 in Participants With Advanced or Metastatic Solid Tumours
- Research Site, Los Angeles
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Aug 13, 2026 · NCT06795022A Study of MGC026 in Participants With Advanced Solid Tumors
- The Angeles Clinic and Research Institute, Los Angeles
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT06242470A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
- Los Angeles Cancer Network, Los Angeles
- Pih Health Hematology Medical Oncology, Whittier
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06330064A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations
- Precision NextGen Oncology & Research Center, Beverly Hills
- UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco
- University of California Los Angeles Rheumatology, Westwood, Los Angeles
RecruitingPhase 2
Ages 8 and older · All sexes · Updated Jul 27, 2026 · NCT05503797A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors
- Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
- UC Irvine Health - Chao Family Comprehensive Cancer Center, Orange
- University of California Davis Comprehensive Cancer Center, Sacramento
- and 1 more
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT05208762Multi-analyte Blood Test Clinical Trial
- Gastroenterology and Liver Institute, Escondido
- Providence Facey Medical Foundation, Mission Hills
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT05199259A Noninvasive and Screening miRNA Signature for Gastrointestinal Cancer
- City of Hope Nat Medical Ctr, Duarte
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT07224750An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer
- City of Hope Medical Center, Duarte
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT06342414ET140203 T Cells in Pediatric Subjects With Hepatoblastoma, HCN-NOS, or Hepatocellular Carcinoma
- Children's Hospital Los Angeles, Los Angeles
- Children's Hospital Orange County, Orange
- UCSF Benioff Children's Hospitals, San Francisco
RecruitingPhase 1/2
Ages 1 to 21 · All sexes · Updated Jul 6, 2026 · NCT04634357Project for Multi-Omics-Based Early Detection of Hepatocellular Carcinoma (PROMETHEA Study)
- City of Hope Medical Center, Duarte
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jul 1, 2026 · NCT07265271Cabozantinib Combined With Ipilimumab/Nivolumab and TACE in Patients With Hepatocellular Carcinoma
- Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 1, 2026 · NCT04472767PSMA PET for the Staging and Management of Hepatocellular Carcinoma
- VA Greater Los Angeles Healthcare System, West Los Angeles, CA, West Los Angeles
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 26, 2026 · NCT07019844Time-restricted Eating and Healthy Eating in Patients With Metabolic Liver Disease or Cancer
- University of California San Diego, La Jolla
Recruiting
Ages 18 and older · All sexes · Updated Jun 25, 2026 · NCT06824974A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinoma
- Clinical Trial Site, La Jolla
- Clinical Trial Site, Los Angeles
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jun 17, 2026 · NCT06600321Preventing Liver Cancer Mortality Through Imaging With Ultrasound vs. MRI
- VA Long Beach Healthcare System, Long Beach, CA, Long Beach
- VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto
- VA Northern California Health Care System, Mather, CA, Sacramento
- and 2 more
Recruiting
Ages 18 to 75 · All sexes · Updated Jun 17, 2026 · NCT05486572A Phase 1/1B Study of ST-01156, a Small Molecule RBM39 Degrader, in Patients With Advanced Solid Malignancies
- The City of Hope National Medical Center, Duarte
- Hoag Memorial Hospital, Newport Beach
RecruitingPhase 1
Ages 16 and older · All sexes · Updated Jun 2, 2026 · NCT07197554DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors
- USA06-0, Los Angeles
- USA16-0, Los Angeles
RecruitingPhase 2
Ages 18 and older · All sexes · Updated May 22, 2026 · NCT06953089A Study of TTI-101 as Monotherapy and in Combination in Participants With Locally Advanced or Metastatic, and Unresectable Hepatocellular Carcinoma
- Norris Comprehensive Cancer Center, Los Angeles
- University of California Irvine Medical Center, Orange
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Apr 27, 2026 · NCT05440708From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.